ID M9P1C2_9CLOS Unreviewed; 2237 AA.
AC M9P1C2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=245 kDa polyprotein {ECO:0000313|EMBL:AFV73379.1};
OS Grapevine leafroll-associated virus 3.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Martellivirales; Closteroviridae; Ampelovirus.
OX NCBI_TaxID=55951 {ECO:0000313|EMBL:AFV73379.1};
RN [1] {ECO:0000313|EMBL:AFV73379.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3138-07 {ECO:0000313|EMBL:AFV73379.1};
RA Rott M.E., Belton M.;
RT "Detection of grapevine and tree fruit viruses by next generation
RT sequencing.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JX559645; AFV73379.1; -; Genomic_RNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF01443; Viral_helicase1; 1.
DR Pfam; PF01660; Vmethyltransf; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1069..1087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1154..1175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 478..669
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 1601..1694
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT DOMAIN 1902..2230
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT REGION 143..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1708..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2237 AA; 245089 MW; 864EFE77524C55C9 CRC64;
MDYIRPLRVF SFPHVNNTLE YVRYNKANGD VGAFLTTMKF IGNVKLSDFT PRCAAMIYIG
KLTKGVKRTF VPPPVKGFAR QYAVVSGSVS ALRGDGKKVL MEARTSTSAT SDVSDFDVVF
EAVSNALLVV HYHRVVPYAP VKREQPKPAV KQDEQKPKRQ ASHWAVKPTA VGVHVPLPKK
QEALEPAQSV PQQSLEEKAA LTFGLFFSKG GGDESDAVIL RKGKLFNRAL NVPIDVKNTF
VWAKIWDEAS RRRGYFYVKD RAVKFFPIVR GRATIEDFIV NTAPGCDVAL PRIELWSMRE
RAFVCTTRGW CWFNNERLRG EIYRRRCFSS SFSVGFLMHM GFRSLKAVRF AGTNILHIPS
LNEERTFGWK SADVYLPNVP KTAIVAGDRT RLGGEILASV ANALNQEEVY SSVVSSITNR
LVLRDQSALL SHLDTKLCDM FSQRDAMIRE KPSHRCDVFL KPQEKERLRE LFPELSIQFS
DSVRSSHPFA NAMRSCFNGI FSRRCGGVCF FDIGGSFTYH VKAGHVNCHV CNPVLDVKDV
KRRINEILFL STAGGDSYVS SDLLTEAASK SVSYCSRESQ NCDSRADAGF MVDVYDISPQ
QVAEAMDKKG ALVFDLALMF PVELLYGNGE VYLEELDTLV KREGDYLAYN VGQCGEMYEH
SFSNVSGFFT FSYVRTSSGN VFKLEYEGYR CGYHHLTMCR AQKSPGTEVT RRSLVPTFVG
KSLVFIPVVA GSSVSFKTIV LDSDFVDRIY SYALNTIGTF ENRTFEYAVG AVRSQKTHVI
TGSRVVHSKV DISPDDMWGL VVAVMAQAIK DRAKSIRSYN FIKASEGSLA GVFKLFFQTV
GDCFSSVVST YAKAMVHDNF NVLETLISMP KAFICKVPGS VVVTICTSGA SDRLELRGAF
DVSKETFGRK LKNSRLRVFS RAIVEDSIKV MKAMKTEDGK PLPITEDSVH AFIMGNISNV
HCTRAGLLGG SKAAVVSGVS KGLVARGAAT KAFSGVASFF STGSLFYDRG LTEDERLDAL
VRTENAINSP VGILETSRVA VSKVVAGTKE FWSEVSLNDF TTFVLRNKVL IGIFVASLGA
APIAWKYRRG IAANARRYAG GSYETLSSLS SQAAGGLRGL TSSTVSGGSL VVRRGFSSAV
TVTRATVAKR QVPLALLSFS TSYAISGCSM LGIWAHALPR HLMFFFGLGT LLGARASANT
WKFGGFSNNW CAVPEVVWRG KSVSSLLLPI TLGVSLIIRG LLNDTIPQLA YVPPVEGRNV
YDETLRYYRD FDYDEGAGPS GTQHEAVPGY DNDGSTSSVS SYDGVTNVRD VGISTNGEVT
GEEETHSPRS VQYTYVEEEV APSAAVAERQ GDPSGSGTAD AMAFVESVKK GVEDVFHQQS
SGETAREVEV DDKGLLPESD IGDAPIQEGG RAVDDNTAQA AADEGHREPV QSSPESVPPA
AVPKVAKSEI PAQKEVKLEV PPTTVPSATP LVEEKPAPSV TTRGVKIIDK GKAIAYVAEK
KQVKAEPPRQ RNLTINEGKA GKQLCMFRTC SCGVQLDVYN EATIATRFSN AFTFVDNLKG
RSAVFFSKLG EGYTYNGGSH VSSGWPRVLE DILTAIKYPS VFDHCLVQKY KMGGGVPFHA
DDEECYPSDN PILTVNLVGK ANFSIKCRKG GKVMVINVAS GDYFLMPCGF QRTHLHSVNS
IDEGRISLTF RATRRVFGVG RMLQLAGGVS DEKSPGVPNQ QPQSQGATRT ITPKSGGKAL
SEGSGREVKG RSTYSIWCEQ DYVKKCEWLR ADNPVMALKP DYTPMTFEVV KTGTSEDAVV
EYLKYLAIGI ERTYRALLMA RNIAVTTAEG VLKVPNQVYE SLPGFHVYKS GTDLIFHSTQ
DGLRVRDLPY VFIAEKGIFT KGKDVDAVVA LGDNLFVCDD ILVFHDAINL IGALKVARCG
MVGESFKSFE YKCYNAPPGG GKTTMLVDEF VKSPNSTATI TANVGSSEDI NMAVKKRDPN
LEGLNSATTV NSRVVNFIVR GMYKRVLVDE VYMMHQGLLQ LGVFATGASE GLFFGDINQI
PFINREKVFR MDCAVFVPKK ESVVYTSKSY RCPLDVCYLL SSMTVRGTEK CYPEKVVSGK
DKPVVRSLSK RPIGTTDDVA EINADVYLCM TQLEKSDMKR SLKGKGKETP VMTVHEAQGK
TFSDVVLFRT KKADDSLFTK QPHILVGLSR HTRSLVYAAL SSKLDDKVGT YISDASPQSV
SDALLHTFAP AGCFRGI
//
