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Database: UniProt
Entry: M9PBX8_DROME
LinkDB: M9PBX8_DROME
Original site: M9PBX8_DROME 
ID   M9PBX8_DROME            Unreviewed;      1195 AA.
AC   M9PBX8;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   22-NOV-2017, entry version 36.
DE   SubName: Full=Transient receptor potential cation channel A1, isoform K {ECO:0000313|EMBL:AGB94297.1};
GN   Name=TrpA1 {ECO:0000313|EMBL:AGB94297.1,
GN   ECO:0000313|FlyBase:FBgn0035934};
GN   Synonyms=ANKTM1 {ECO:0000313|EMBL:AGB94297.1}, Anktm1
GN   {ECO:0000313|EMBL:AGB94297.1}, CG5761 {ECO:0000313|EMBL:AGB94297.1},
GN   CT18073 {ECO:0000313|EMBL:AGB94297.1}, dANKTM1
GN   {ECO:0000313|EMBL:AGB94297.1}, Dmel\CG5751
GN   {ECO:0000313|EMBL:AGB94297.1}, DmTRPA1 {ECO:0000313|EMBL:AGB94297.1},
GN   dTRPA {ECO:0000313|EMBL:AGB94297.1}, dTrpA
GN   {ECO:0000313|EMBL:AGB94297.1}, dTRPA1 {ECO:0000313|EMBL:AGB94297.1},
GN   dTrpA1 {ECO:0000313|EMBL:AGB94297.1}, dtrpA1
GN   {ECO:0000313|EMBL:AGB94297.1}, Trp1A {ECO:0000313|EMBL:AGB94297.1},
GN   TRPA {ECO:0000313|EMBL:AGB94297.1}, TrpA
GN   {ECO:0000313|EMBL:AGB94297.1}, TRPA1 {ECO:0000313|EMBL:AGB94297.1},
GN   Trpa1 {ECO:0000313|EMBL:AGB94297.1}, trpA1
GN   {ECO:0000313|EMBL:AGB94297.1};
GN   ORFNames=CG5751 {ECO:0000313|EMBL:AGB94297.1,
GN   ECO:0000313|FlyBase:FBgn0035934}, Dmel_CG5751
GN   {ECO:0000313|EMBL:AGB94297.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AGB94297.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; AE014296; AGB94297.1; -; Genomic_DNA.
DR   RefSeq; NP_001261602.1; NM_001274673.1.
DR   UniGene; Dm.15461; -.
DR   SMR; M9PBX8; -.
DR   PaxDb; M9PBX8; -.
DR   EnsemblMetazoa; FBtr0331827; FBpp0304211; FBgn0035934.
DR   GeneID; 39015; -.
DR   CTD; 8989; -.
DR   FlyBase; FBgn0035934; TrpA1.
DR   eggNOG; KOG0510; Eukaryota.
DR   eggNOG; KOG1326; Eukaryota.
DR   eggNOG; COG0666; LUCA.
DR   GeneTree; ENSGT00900000140877; -.
DR   OrthoDB; EOG091G01BG; -.
DR   GenomeRNAi; 39015; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0035934; -.
DR   ExpressionAtlas; M9PBX8; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 4.
DR   Gene3D; 1.25.40.20; -; 5.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR030288; TRPA1/painless.
DR   PANTHER; PTHR24190; PTHR24190; 1.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF12796; Ank_2; 3.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 15.
DR   SUPFAM; SSF48403; SSF48403; 3.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 10.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:AGB94297.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    749    771       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    823    841       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    853    875       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    887    908       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    928    950       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    970    991       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1003   1026       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       90    637       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      124    156       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      157    189       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      225    246       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      300    332       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      371    403       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      404    436       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      478    510       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      511    533       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      547    579       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   REPEAT      613    637       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   1195 AA;  134730 MW;  3AFBB9330FDC38BB CRC64;
     MPKLYNGVYS GQCGALSPPD LMEAQPKLLP KPRSNSSGST GRNSKYWIFS MIIERSAGPK
     RIEIDGDDAD TPLEAILPAE PPAEVCLLRD SPFRILRAAE SGNLDDFKRL FMADNSRIAL
     KDAKGRTAAH QAAARNRVNI LRYIRDQNGD FNAKDNAGNT PLHIAVESDA YDALDYLLSI
     PVDTGVLNEK KQAPVHLATE LNKVKSLRVM GQYRNVIDIQ QGGEHGRTAL HLAAIYDHEE
     CARILITEFD ACPRKPCNNG YYPIHEAAKN ASSKTMEVFF QWGEQRGCTR EEMISFYDSE
     GNVPLHSAVH GGDIKAVELC LKSGAKISTQ QHDLSTPVHL ACAQGAIDIV KLMFEMQPME
     KRLCLSCTDV QKMTPLHCAS MFDHPDIVSY LVAEGADINA LDKEHRSPLL LAASRSGWKT
     VHLLIRLGAC ISVKDAAARN VLHFVIMNGG RLTDFAEQVA NCQTQAQLKL LLNEKDSMGC
     SPLHYASRDG HIRSLENLIR LGACINLKNN NNESPLHFAA RYGRYNTVRQ LLDSEKGSFI
     INESDGAGMT PLHISSQQGH TRVVQLLLNR GALLHRDHTG RNPLQLAAMS GYTETIELLH
     SVHSHLLDQV DKDGNTALHL ATMENKPHAI SVLMSMGCKL VYNVLDMSAI DYAIYYKYPE
     AALAMVTHEE RANEVMALRS DKHPCVTLAL IASMPKVFEA VQDKCITKAN CKKDSKSFYT
     MVTHGRVELL AHPLSQKYLQ MKWNSYGKYF HLANLLIYSI FLVFVTIYSS LMMNNIELKA
     GDNKTMSQYC NMGWEQLTMN LSQNPSVASQ IRLDSCEERI NRTTAILFCA VVIVVYILLN
     SMRELIQIYQ QKLHYILETV NLISWVLYIS ALVMVTPAFQ PDGGINTIHY SAASIAVFLS
     WFRLLLFLQR FDQVGIYVVM FLEILQTLIK VLMVFSILII AFGLAFYILL SKIIDPQPNH
     LSFSNIPMSL LRTFSMMLGE LDFVGTYVNT YYRDQLKVPM TSFLILSVFM ILMPILLMNL
     LIGLAVGDIE SVRRNAQLKR LAMQVVLHTE LERKLPHVWL QRVDKMELIE YPNETKCKLG
     FCDFILRKWF SNPFTEDSSM DVISFDNNDD YINAELERQR RKLRDISRML EQQHHLVRLI
     VQKMEIKTEA DDVDEGISPN ELRSVVGLRS AGGNRWNSPR VRNKLRAALS FNKSM
//
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