ID M9PD19_DROME Unreviewed; 1779 AA.
AC M9PD19;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Miles to go, isoform H {ECO:0000313|EMBL:AGB93039.1};
GN Name=mtgo {ECO:0000313|EMBL:AGB93039.1,
GN ECO:0000313|FlyBase:FBgn0259735};
GN Synonyms=anon-EST:Liang-1.16 {ECO:0000313|EMBL:AGB93039.1}, CG13260
GN {ECO:0000313|EMBL:AGB93039.1}, CG13261 {ECO:0000313|EMBL:AGB93039.1},
GN CG31738 {ECO:0000313|EMBL:AGB93039.1}, CG4668
GN {ECO:0000313|EMBL:AGB93039.1}, clone 1.16
GN {ECO:0000313|EMBL:AGB93039.1}, CT15043 {ECO:0000313|EMBL:AGB93039.1},
GN CT15049 {ECO:0000313|EMBL:AGB93039.1}, Dmel\CG42389
GN {ECO:0000313|EMBL:AGB93039.1};
GN ORFNames=CG42389 {ECO:0000313|EMBL:AGB93039.1,
GN ECO:0000313|FlyBase:FBgn0259735}, Dmel_CG42389
GN {ECO:0000313|EMBL:AGB93039.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB93039.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AGB93039.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AGB93039.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AGB93039.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AGB93039.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AGB93039.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SIMILARITY: Belongs to the FNDC3 family.
CC {ECO:0000256|ARBA:ARBA00038207}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014134; AGB93039.1; -; Genomic_DNA.
DR RefSeq; NP_001260504.1; NM_001273575.1.
DR SMR; M9PD19; -.
DR DNASU; 34987; -.
DR EnsemblMetazoa; FBtr0335497; FBpp0307467; FBgn0259735.
DR GeneID; 34987; -.
DR AGR; FB:FBgn0259735; -.
DR CTD; 34987; -.
DR FlyBase; FBgn0259735; mtgo.
DR VEuPathDB; VectorBase:FBgn0259735; -.
DR GeneTree; ENSGT00940000167764; -.
DR OMA; GETEAMC; -.
DR OrthoDB; 316463at2759; -.
DR PhylomeDB; M9PD19; -.
DR BioGRID-ORCS; 34987; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG42389; fly.
DR GenomeRNAi; 34987; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0259735; Expressed in embryonic/larval hemocyte (Drosophila) and 23 other cell types or tissues.
DR ExpressionAtlas; M9PD19; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; HDA:FlyBase.
DR CDD; cd00063; FN3; 8.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF11; FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED; 1.
DR Pfam; PF00041; fn3; 4.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 8.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:M9PD19};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1759..1777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 646..743
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 747..842
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 846..934
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 938..1030
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1034..1128
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1132..1238
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1239..1327
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1328..1432
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1493..1519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1572..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..194
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..437
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..493
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1687..1704
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1779 AA; 191899 MW; CD4C520A9FE4163A CRC64;
MVRLNVAEQH SSSNNNGNIS NSSISNTNGT IITSNNNAGG SCSSTTSSTT SLNSNPASPA
CTMVMLPAPQ QHLLVQQQQQ QQQQQQQQQQ PQQPPPQLQQ QHGPQQQQQQ QQQQHSPSDG
GSSNCSLPAS PPLLQQTATP PQGAQIVPPV CALHHPQQQL ALMAAMQHHH HLPPPHALHH
APLPPPPPNL PPPHENGHGG GGSGVAVGGG GISPNGGGGS SASSVSSLSS GSGGSGGQVN
GLSNGTNGIA PLPPGQLYIQ YPGEFYPPEY YIAPHPHEGI CPQHPHHPHP HHHQPMCAMS
TEYGKPQSKM ITYTHCFDLK CPAVQMVSQN RPPPPMPVPV QVPQYVNENG TLTHVMLSPQ
QYQQLHPGQG HLHPAPFISA NGTSHFYTPV AGYPGPGPAG NGPPHYHLPP PPPPQQQQQQ
PPQQPQQQAP QGPPPPQQQQ QQQQQVAPPA VQGAPSTGSV GAAQGAPATA TATHTHAHSH
SHSHAHSHTH PQPHAHSPHS PSPPNYRDER SQRQHNKLLR KLEKQRESNP PHSPSPRRAN
ELNGHNNNNI PPGVPLPGHL NNHHHAVNHQ GRRLPQQHQG QAHQVAQQQQ SQARNGNPQH
PQRAGSSVGG ASSVGTSEDG EDNSSLAGDD EEEYHRENSI IEQISAIEKP EVIDVTSRAA
KIIWESPAIA NTVTVDMRQL RYQVLLCDSG KQCKYKSLYQ GEAYECIVQD LQPGQDYLVR
LQVHYQKLTG TVSDPTEFRT PPCEPDQPPP PKLVSRTKNS INLRWAAPAA NGASIQHYLL
EYDEGRMPGQ PQKFVELAKI KAKHYVIGKL QPTTVYSFRL AAVNEAGQSP YSPVASYSTS
GNPPPVPKPP QLLASSSSSL KLGWERRAQD GDFLLQLQDA ETGHGFLNTY KGTELQTECL
QLRRASSYQF RLRSENEAGF SPWSPEVSYR TLAERPGRPG KPHAKGKIHG TQFKARWDAP
SDSGGAEILC YHLELSAAGP AFERIYSGAE TEAMCERLQP GTTYALRACC EGPAGQSPYS
DIGHVTTEAV PPSAPPPPHC SDPPSPYAAL LKLRPPEYNG GAPILEFEAQ MRRLEQVQPP
QLVYRGKQTY FVAQDLTPGG MYETQVRAIN RIGAGSWSQW MRFTAAAAAP GVPEELRVLV
KSATHLGVSW QPPLQENGAP VTSYTLKSAS QERKEDDSEE EVKEPPSSEF HNCYQGPQTC
AELRNLSPYT RYHFRIQASN SAGTGNSSDV ISVCTPAAVP GAPQMQGYEF TAQEVTLNWT
QPAAHGSPIC SYNIEYGERT IATPDACTRY TVSGLMPETG YKFRVQAVNA IGAGAFSAYA
KLTTQPAPPA PPRLECSGAG HNYIKLKWGE NGNGKVVNSN PSGNGGDFTK YFVEMYVARA
KQFQAVYSGT NCMCKVHKLQ ERSSYTFRIY AHTDRAGDGD YSEEFVFETS ATLPANIKPP
RVVQEGSVCL MELPGQLGMQ LTLEWQHSKN SFNDRVEYEL QYAVLGAAEL EGESLSPKGR
SSSSSGSSNG APINLPNHDY RQLYRGPETK FTIDNLAAGT CYQFRVCPVR IAAGGELLYG
QPSSPLRYQV PSELDPSSAT CHHHLHGSTA TPAMASSQRS SRKLSAGNGS TNGLHMRSVS
ASAISGASGV GADPVAIGRL QQELSGFNAC ADPQHHHHHH HHHHHQPCGG GVGGAGGISG
ATDSHHQHQH HMHHSHHMHH AHHPHTGMGG SSSNSSSSTA AAISSSLAQA GGLRRIVCKV
TSLYSNRRRL SDQQKAVCIV VSFLVGTFLV AMLVNMLRG
//
