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Database: UniProt
Entry: M9PE38_DROME
LinkDB: M9PE38_DROME
Original site: M9PE38_DROME 
ID   M9PE38_DROME            Unreviewed;      1602 AA.
AC   M9PE38;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-SEP-2017, entry version 39.
DE   SubName: Full=Shaker cognate b, isoform I {ECO:0000313|EMBL:ADV37476.1};
DE   SubName: Full=Shaker cognate b, isoform N {ECO:0000313|EMBL:AGB94040.1};
GN   Name=Shab {ECO:0000313|EMBL:AGB94040.1,
GN   ECO:0000313|FlyBase:FBgn0262593};
GN   Synonyms=Dmel\CG43128 {ECO:0000313|EMBL:AGB94040.1}, dShab
GN   {ECO:0000313|EMBL:AGB94040.1}, K[[v]]2 {ECO:0000313|EMBL:AGB94040.1},
GN   Kv2 {ECO:0000313|EMBL:AGB94040.1}, shab {ECO:0000313|EMBL:AGB94040.1},
GN   shb {ECO:0000313|EMBL:AGB94040.1};
GN   ORFNames=CG1066 {ECO:0000313|EMBL:AGB94040.1}, CG43128
GN   {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|FlyBase:FBgn0262593}, CG9965
GN   {ECO:0000313|EMBL:AGB94040.1}, Dmel_CG43128
GN   {ECO:0000313|EMBL:AGB94040.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
RN   [5] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AGB94040.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:AGB94040.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
RA   Yu C., Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [10] {ECO:0000313|EMBL:AGB94040.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [11] {ECO:0000313|EMBL:AGB94040.1}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; AE014296; ADV37476.1; -; Genomic_DNA.
DR   EMBL; AE014296; AGB94040.1; -; Genomic_DNA.
DR   RefSeq; NP_001189039.1; NM_001202110.2.
DR   RefSeq; NP_001261345.1; NM_001274416.1.
DR   UniGene; Dm.2563; -.
DR   EnsemblMetazoa; FBtr0305206; FBpp0293736; FBgn0262593.
DR   EnsemblMetazoa; FBtr0333899; FBpp0306031; FBgn0262593.
DR   GeneID; 38352; -.
DR   CTD; 38352; -.
DR   FlyBase; FBgn0262593; Shab.
DR   eggNOG; KOG3713; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118981; -.
DR   OrthoDB; EOG091G0FP3; -.
DR   ChiTaRS; Shab; fly.
DR   GenomeRNAi; 38352; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0262593; -.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01494; KV9CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   TRANSMEM    462    484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    504    523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    535    555       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    607    628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    637    656       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    668    693       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      307    416       BTB. {ECO:0000259|SMART:SM00225}.
FT   COILED      846    876       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1602 AA;  171687 MW;  D589DA4746221153 CRC64;
     MVGERDRDRE AVRWATGEST PLQTNNGVLQ MVGQLQGGQA AGQQQQQQQA TQQQQHSKQQ
     QQQQQQQQQQ LQLKQHQQQQ QDILYQQHNE AIAIARGLQA ATPADIGDNQ PYYDTSGNVD
     WERAMGAGGA GAYGGIGIGS LPAAGGAAYH LGPANPAGLV SRHLDYGDGG HLAGPSAGLP
     AGAVGSGAGA GAGAGASVTG SGSGAGTGTG TGAGSGSGSG AAGKEVRYAP FPVASPTHSI
     PTTSQQIVGS VGGVGVGGAS SQSISGGVPT HSQSNTTGAL QRTHSRSMSS IPPPEPFMIA
     QSKAVNSRVS INVGGVRHEV LWRTLERLPH TRLGRLRECT THEAIVELCD DYSLADNEYF
     FDRHPKSFSS ILNFYRTGKL HIVDEMCVLA FSDDLEYWGV DELYLESCCQ HKYHQRKENV
     HEEMRKEAES LRQRDEEEFG EGKCAEYQKY LWELLEKPNT SFAARVIAVI SILFIVLSTI
     ALTLNTLPQL QHIDNGTPQD NPQLAMVEAV CITWFTLEYI LRFSASPDKW KFFKGGLNII
     DLLAILPYFV SLFLLETNKN ATDQFQDVRR VVQVFRIMRI LRILKLARHS TGLQSLGFTL
     RNSYKELGLL MLFLAMGVLI FSSLAYFAEK DEKDTKFVSI PETFWWAGIT MTTVGYGDIY
     PTTALGKVIG TVCCICGVLV IALPIPIIVN NFAEFYKNQM RREKALKRRE ALDRAKREGS
     IVSFHHINLK DAFAKSMDLI DVIVDTEKRE SHTRSLKNWH RLTHALRRSP TGHNLSQTDG
     NSTEGESTSG RNPATTGTGC YKNYDHVANL RNSNLHNRRG SSSEQDAVPP YSFDNPNARQ
     TSMMAMESYR REQQALLQQQ QQQQQQMLQM QQIQQKAPNG NGGATGGGVA NNLAMVAASS
     AATAVATATN ASNASNTAPG SEGAEGGGDG DGGGVDDDNL SQAKGLPIQM MITPGEVAEL
     RRQVALENLQ NQRMDNLEQD VPVEFECCFC TTKDFKEFTD AEGVISLPTS DFHKPICLEM
     RLAAAGRQAG AYGLLSPLPA PLPPLHGPLL ALPPPPPLPP TSCAAVLLPA ISQSSSTSSS
     YGTTTSTTIA LPLDVSLRYG ATICSSSNFN HNYNNNFNTT TVGGGGNGTL LFGGNYNGSN
     NNNADLASVD SSDTYASCQT HPFLSQGDLT ADFNDEACAL DIDMDNLYIN PLEREQHQGI
     SSSTGFIVGL PSTNSSGGPR AQVKKSASGD TALRNLAAGG VGAGGLSPLN DVYQSFDVQE
     RGSRVSLNEN SVPKHRKTRF QQSFTAMRPS GATGVLGSSV LGGMRPRARF EDTKLDDETG
     GRREGELAGG SGSPAASGSG GLSGQGPKKK RSVFMPGKSL ATATKLINQH LFGIQNVGAK
     AKFESKHSSS IDSIDASPNL EHHRRSKSIL KNKSDISRVL SDPESERLLA DNMSGSGVSD
     NGTVMGESGS DYSPNKLPHS VLAKSISPPP LRHRTLMHQR SGPATLQSKP TKFQTPRYPE
     EQALRQVKPL LSRGTPSTSA SAGSADGQQT RDSSLDSETT FTSPVSHRAG EDPPTAPPSQ
     AAVATGQEDR EEEGEAEAND EQRALLQGAD TEEAKRAGNE GT
//
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