ID M9PHG8_DROME Unreviewed; 4660 AA.
AC M9PHG8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Dynein heavy chain 64C, isoform H {ECO:0000313|EMBL:AGB94126.1};
GN Name=Dhc64C {ECO:0000313|EMBL:AGB94126.1,
GN ECO:0000313|FlyBase:FBgn0261797};
GN Synonyms=CD {ECO:0000313|EMBL:AGB94126.1}, Cdhc
GN {ECO:0000313|EMBL:AGB94126.1}, cDhc {ECO:0000313|EMBL:AGB94126.1},
GN cDhc64C {ECO:0000313|EMBL:AGB94126.1}, DHC
GN {ECO:0000313|EMBL:AGB94126.1}, Dhc {ECO:0000313|EMBL:AGB94126.1}, dhc
GN {ECO:0000313|EMBL:AGB94126.1}, Dhc 64C {ECO:0000313|EMBL:AGB94126.1},
GN DHC1 {ECO:0000313|EMBL:AGB94126.1}, Dhc46C
GN {ECO:0000313|EMBL:AGB94126.1}, Dhc64 {ECO:0000313|EMBL:AGB94126.1},
GN dhc64 {ECO:0000313|EMBL:AGB94126.1}, DHC64C
GN {ECO:0000313|EMBL:AGB94126.1}, Dhc64c {ECO:0000313|EMBL:AGB94126.1},
GN dhc64C {ECO:0000313|EMBL:AGB94126.1}, dhc64c
GN {ECO:0000313|EMBL:AGB94126.1}, Dmel\CG7507
GN {ECO:0000313|EMBL:AGB94126.1}, DYHC {ECO:0000313|EMBL:AGB94126.1},
GN Dynein {ECO:0000313|EMBL:AGB94126.1}, dynein
GN {ECO:0000313|EMBL:AGB94126.1}, FCP-A {ECO:0000313|EMBL:AGB94126.1},
GN Fs(3)Lab {ECO:0000313|EMBL:AGB94126.1}, Fs(3)Laborc
GN {ECO:0000313|EMBL:AGB94126.1}, Fs(3)Sz18
GN {ECO:0000313|EMBL:AGB94126.1}, HMW MAP {ECO:0000313|EMBL:AGB94126.1},
GN l(3)64Ca {ECO:0000313|EMBL:AGB94126.1}, Lab
GN {ECO:0000313|EMBL:AGB94126.1}, Su(Gl)77 {ECO:0000313|EMBL:AGB94126.1};
GN ORFNames=CG7507 {ECO:0000313|EMBL:AGB94126.1,
GN ECO:0000313|FlyBase:FBgn0261797}, Dmel_CG7507
GN {ECO:0000313|EMBL:AGB94126.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AGB94126.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AGB94126.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AGB94126.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AGB94126.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AGB94126.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AGB94126.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AE014296; AGB94126.1; -; Genomic_DNA.
DR RefSeq; NP_001261431.1; NM_001274502.1.
DR SMR; M9PHG8; -.
DR EnsemblMetazoa; FBtr0332749; FBpp0304990; FBgn0261797.
DR GeneID; 38580; -.
DR AGR; FB:FBgn0261797; -.
DR CTD; 38580; -.
DR FlyBase; FBgn0261797; Dhc64C.
DR VEuPathDB; VectorBase:FBgn0261797; -.
DR GeneTree; ENSGT00940000156103; -.
DR OrthoDB; 312195at2759; -.
DR BioGRID-ORCS; 38580; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38580; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0261797; Expressed in eye disc (Drosophila) and 25 other cell types or tissues.
DR ExpressionAtlas; M9PHG8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:UniProtKB-EC.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:M9PHG8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1903..2052
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2224..2375
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2594..2744
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2936..3102
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 537..564
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1283..1313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3215..3260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3409..3492
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4660 AA; 532322 MW; 34BDE971AD61A022 CRC64;
MGDSLENPDT SVDPIVNLSI ANYDAFANYL RKAVTILLPE DDVVPASLND ALDDPVNQDT
IRKFLSDPQV QALYVQRNCI KEDDSEQPAE GEDEKEQVTY QISNDVHFTN SRMASLACIK
RGLVVEADKS IHSQLRLINF SDGSPYETLH AFISKSLAPY FKSYVKESGR ADRDGDKMAP
SVEKKLAELE MGLLHLQQNI DIPEITLTAH QTVNNVIRKC AEENRKAKVA DFGDKVEDSS
FLNLLQNGVN RWIAEIKKVT KLNRDPGSGT ALQEISFWLN LERALYRIQE KRESPEVALT
LDILKHGKRF HATVSFDTDT GLKQALATVA DYNPLMKDFP INDLLSATEL EKIRPAVQQI
FAHLRKVRNT KYPIQRCLKL IEAISRDLSQ QLLKVLGTRR LMHIPFDEFE RVMNQCFEIF
SCWDDEYDKL QGLLRDIVKK KRDEHLKMVW RVSPAHKKLQ TRMEHMRKFR RQHEQLRTVI
LRVLRPTKPA VGDDGNVVET KQPYSLDAAD ANAIEEVNLA YENVKEVDCL DITKEGSEAW
EAAVKRYEEK IDRVETRITA HLRDQLGTAK NANEMFRIFS RFNALFVRPH IRGAIREYQT
QLIQRVKDDI EALHEKFKVQ YPQSKSCRLS SVRDLPPVAG SIIWARQIDN QLTMYLKRVE
DVLGKGWETH IEGQKLKADG DSFRAKLSIS DVFHEWARKV QERNFGSTGR IFTIESTRSR
IGRGNVLRLR VNFLPEIITL AKEVRNIKNL GFRVPLTIVN KAHQANQIYP YAISLIESVR
TYERTLEKLN NRSLAQNSVF KIEDRASIVP LVAGLRKDVL NLVSEGIGLI WESYKLDPYV
IRLSECVTQF QEKVDDLLVV EEQLDVDVRS LETCPYSAAT FVEILSKIQH AVDDLSLRQY
SNLSVWVTRL DEEVEKKLAL RLQAGIQAWT EALTGNKKEV DTSMDTDAPA QPTHKLGGDP
QIQNAVHEIR ITNQQMYLYP SIEEARFQIM QQFFAWQAIV TSQVRLQSTR YQVGLEKHVS
QTYRNLLTKL PEGKILENAY GAIEQKVSEV RNYVDEWLRY QSLWDLQADM LYGRLGEDVN
LWIKCLNDIK QSRTTFDTSD TRRAYGPIII DYAKVQAKVT LKYDSWHKEA LGKFGTLLGT
EMTSFHSKVS KSRTDLEMQS IEAASTSDAV SFITYVQSLK KDMIAWDKQV EVFREAQRIL
ERQRFQFPNT WLHVDNIEGE WSAFNEIIKR KDTAIQTQVA SLQAKIVAED KAVETRTVDF
LNDWEKTKPT GGKIRPDDAL QQLQIFESKY SRLKEERDNV VKAKEALELQ ESAVPNNSAE
RMNVALEELQ DLRGVWSELS KVWTQIDETR EKPWLSVQPR KLRQQLEAMM AQLKELPARL
RMYESYEYVK KLIQSYIKVN MLIVELKSDA LKERHWKQLT KQLRVNWVLS DLSLGQVWDV
NLQKNEGIVK DIILVAQGEM ALEEFLKQVR ESWQNYELDL INYQNKCRII RGWDDLFNKV
KEHINSVAAM KLSPYYKVFE EEALTWEEKL NRINALFDVW IDVQRRWVYL EGIFSGSADI
KTLLPVETSR FQSISSEFLG LMKKVTKSPK VMDVLNIPAV QRSLERLADL LGKIQKALGE
YLERERTSFP RFYFVGDEDL LEIIGNSKNI ARLQKHFKKM FAGVAAILLN EENNVILGIS
SREGEEVHFM NPVSTVEHPK INEWLSLVEK QMRFTLASLL AQAVQDIKQF RDGKIDPQAY
MEWCDKYQAQ IVVLAAQILW SEDVESALQQ ASENNQSKPM QRVLGNVEST LNVLADSVLQ
EQPPLRRRKL EHLINEFVHK RTVTRRLLNN GVTSPKSFQW LCEMRFYFDP RQTEVLQQLT
IHMANARFFY GFEYLGVQDR LVQTPLTDRC YLTMTQALES RLGGSPFGPA GTGKTESVKA
LGNQLGRFVL VFNCDETFDF QAMGRIFVGL CQVGAWGCFD EFNRLEERML SACSQQIQTI
QEALKYEMDS NKESITVELV GKQVRVSPDM AIFITMNPGY AGRSNLPDNL KKLFRSLAMT
TPDRQLIAEV MLFSQGFRSA EKLACKIVPF FKLCDEQLSN QSHYDFGLRA LKSVLISAGN
VKRDRIMKIK EQMKQRGDEN IDEASVAENL PEQEILIQSV CETMVPKLVA EDIPLLFSLL
SDVFPNVGYT RAEMKGLKEE IRKVCQEDYL VCGEGDEQGA AWMEKGLGST WVDKVLQLYQ
ISNLNHGLMM VGPSGSGKST AWKTLLKALE RFEGVEGVAH VIDPKAISKE ALYGVLDPNT
REWTDGLFTH ILRKIIDNVR GEINKRQWII FDGDVDPEWV ENLNSVLDDN KLLTLPNGER
LSLPPNVRVM FEVQDLKFAT LATVSRCGMV WFSEDVLSTE MIFENYLSRL RSIPLEDGDE
DFVGVIKPAK DKEEEVSPSL QVQRDIALLL LPFFSADGIV VRTLEYAMDQ EHIMDFTRLR
ALSSLFSMLN QAARNVLTFN AQHPDFPCSA DQLEHYIPKA LVYSVLWSFA GDAKLKVRID
LGDFVRSVTT VPLPGAAGAP IIDYEVNMSG DWVPWSNKVP VIEVETHKVA SPDIVVPTLD
TVRHESLLYT WLAEHKPLVL CGPPGSGKTM TLFSALRALP DMEVVGLNFS SATTPELLLK
TFDHYCEYRK TPNGVVLSPV QIGKWLVLFC DEINLPDMDS YGTQRVISFL RQLVEHKGFY
RASDQAWVSL ERIQFVGACN PPTDPGRKPL SHRFLRHVPI IYVDYPGETS LKQIYGTFSR
AMLRLMPALR GYAEPLTNAM VEFYLASQDR FTQDMQPHYV YSPREMTRWV RGICEAIRPL
DSLPVEGLVR LWAHEALRLF QDRLVDDSER RWTNENIDLV GQKHFPGINQ EEALQRPILY
SNWLSKDYMP VNREELREYV HARLKVFYEE ELDVPLVLFD EVLDHVLRID RIFRQPQGHL
LLIGVSGAGK TTLSRFVAWM NGLSIFQIKV HNKYTSEDFD EDLRCVLRRS GCKDEKIAFI
LDESNVLDSG FLERMNTLLA NGEVPGLFEG DEYTTLMTQC KEGAQREGLM LDSSDELYKW
FTQQVMRNLH VVFTMNPSTD GLKDRAATSP ALFNRCVLNW FGDWSDSALF QVGKEFTTRV
DLEKPNWHAP DFFPSVCPLV PANPTHRDAV INSCVYVHQT LHQANARLAK RGGRTMAVTP
RHYLDFIHHF VKLYNEKRSD LEEQQLHLNV GLNKIAETVE QVEEMQKSLA VKKQELQAKN
EAANAKLKQM FQDQQEAEKK KIQSQEIQIR LADQTVKIEE KRKYVMADLA QVEPAVIDAQ
AAVSSIKKKH LAEVRSMANP PAVVKLALES VCELLNESAT DWKAIRGILV KDSFISSIVN
LETDKITDDV REKMKSKYLS NPDYNFEKVN RASMACGPMV KWAIAQIEYA DMLKRVEPLR
EELRSLEEQA DVNLASAKET KDLVEQLERS IAAYKEEYAQ LISQAQAIKT DLENVQAKVD
RSIALLKSLN IERERWESTS ETFKSQMSTI IGDVLLSAAF IAYGGYFDQH YRLNLFTTWS
QHLQAASIQY RADIARTEYL SNPDERLRWQ ANALPTDDLC TENAIMLKRF NRYPLIIDPS
GQATTFLLNE YAGKKITKTS FLDDSFRKNL ESALRFGNPL LVQDVENYDP ILNPVLNREL
RRTGGRVLIT LGDQDIDLSP SFVIFLSTRD PTVEFPPDIC SRVTFVNFTV TRSSLQSQCL
NQVLKAERPD IDEKRSDLLK LQGEFRLRLR QLEKSLLQAL NDAKGKILDD DSVITTLETL
KKEAYDINQK VDETDKVIAE IETVSQQYLP LSVACSNIYF TMDSLNQVHF LYQYSLKMFL
DIFSTVLYNN PKLEGRTDHS ERLGIVTRDL FQVCYERVAR GMIHIDRLTF ALLMCKIHLK
GTSESNLDAE FNFFLRSREG LLANPTPVEG LSAEQIESVN RLALRLPIFR KLLEKVRSIP
ELGAWLQQSS PEQVVPQLWD ESKALSPIAS SVHQLLLIQA FRPDRVIAAA HNVVNTVLGE
DFMPNAEQEL DFTSVVDKQL NCNTPALLCS VPGFDASGRV DDLAAEQNKQ ISSIAIGSAE
GFNQAERAIN MACKTGRWVL LKNVHLAPQW LVQLEKKMHS LQPHSGFRLF LTMEINPKVP
VNLLRAGRIF VFEPPPGIRA NLLRTFSTVP AARMMKTPSE RARLYFLLAW FHAIVQERLR
YVPLGWAKKY EFNESDLRVA CDTLDTWIDT TAMGRTNLPP EKVPWDALVT LLSQSIYGGK
IDNDFDQRLL TSFLKKLFTA RSFEADFALV ANVDGASGGL RHITMPDGTR RDHFLKWIEN
LTDRQTPSWL GLPNNAEKVL LTTRGTDLVS KLLKMQQLED DDELAYSVED QSEQSAVGRG
EDGRPSWMKT LHNSATAWLE LLPKNLQVLK RTVENIKDPL YRYFEREVTS GSRLLQTVIL
DLQDVVLICQ GEKKQTNHHR SMLSELVRGI IPKGWKRYTV PAGCTVIQWI TDFSNRVQQL
QKVSQLVSQA GAKELQGFPV WLGGLLNPEA YITATRQCVA QANSWSLEEL ALDVTITDAG
LKNDQKDCCF GVTGLKLQGA QCKNNELLLA STIMMDLPVT ILKWIKISSE PRISKLTLPV
YLNSTRTELL FTVDLAVAAG QESHSFYERG VAVLTSTALN
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