ID M9T746_9VIRU Unreviewed; 2084 AA.
AC M9T746;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=RNA-directed RNA polymerase L {ECO:0000256|ARBA:ARBA00018602};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE AltName: Full=Large structural protein {ECO:0000256|ARBA:ARBA00030285};
DE AltName: Full=Replicase {ECO:0000256|ARBA:ARBA00031012};
DE AltName: Full=Transcriptase {ECO:0000256|ARBA:ARBA00030436};
OS SFTS virus HNXY_130.
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Ellioviricetes; Bunyavirales; Phenuiviridae; Phlebovirus; SFTS phlebovirus.
OX NCBI_TaxID=1316166 {ECO:0000313|EMBL:AGI97067.1, ECO:0000313|Proteomes:UP000246237};
RN [1] {ECO:0000313|EMBL:AGI97067.1, ECO:0000313|Proteomes:UP000246237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HNXY_130 {ECO:0000313|EMBL:AGI97067.1,
RC ECO:0000313|Proteomes:UP000246237};
RX PubMed=23965284; DOI=10.1093/cid/cit530;
RA Liu W., Lu Q.B., Cui N., Li H., Wang L.Y., Liu K., Yang Z.D., Wang B.J.,
RA Wang H.Y., Zhang Y.Y., Zhuang L., Hu C.Y., Yuan C., Fan X.J., Wang Z.,
RA Zhang L., Zhang X.A., Walker D.H., Cao W.C.;
RT "Case-fatality ratio and effectiveness of ribavirin therapy among
RT hospitalized patients in china who had severe fever with thrombocytopenia
RT syndrome.";
RL Clin. Infect. Dis. 57:1292-1299(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC compartment {ECO:0000256|ARBA:ARBA00004399}. Host Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004136}. Host endoplasmic reticulum-Golgi
CC intermediate compartment {ECO:0000256|ARBA:ARBA00004452}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the Bunyavirales RNA polymerase family.
CC {ECO:0000256|ARBA:ARBA00034123}.
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DR EMBL; KC292342; AGI97067.1; -; Viral_cRNA.
DR Proteomes; UP000246237; Genome.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR InterPro; IPR022531; L_PA-C-like.
DR InterPro; IPR029124; L_protein_N.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR007322; RNA_pol_bunyavir.
DR Pfam; PF04196; Bunya_RdRp; 1.
DR Pfam; PF12603; L_PA-C-like; 1.
DR Pfam; PF15518; L_protein_N; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 3: Inferred from homology;
KW Host endoplasmic reticulum {ECO:0000256|ARBA:ARBA00023184};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 969..1172
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
SQ SEQUENCE 2084 AA; 235440 MW; 4029EEA2CC69085A CRC64;
MNLEVLCGRI NVENGLSLGE PGLYDQIYDR PGLPDLDVTV DATGVTVDIG AVPDSASQLG
SSINAGLITI QLSEAYKINH DFTFSGLSKT TDRRLSEVFP ITHDGSDGMT PDVIHTRLDG
TIVVVEFSTT RSHNIGGLEA AYRTKIEKYR DPISRRVDIM ENPRVFFGVI VVSSGGVLSN
MPLTQDEAEE LMYRFCIANE IYTKARSMDA DIELQKSEEE LEAISRALSF FSLFEPNIER
VEGTFPNSEI EMLEQFLSTP ADVDFITKTL KAKEVEAYAD LCDSHYLKPE KTIQERLEIN
RCEAIDKTQD LLAGLHARSN KQTSLNRGTV KLPPWLPKPS SESIDIKTDS GFGSLMDHGA
YGELWAKCLL DVSLGNVEGV VSDPAKELDI AISDDPEKDT PKEAKITYRR FKPALSSSAR
QEFSLQGVEG KKWKRMAANQ KKEKESHETL SPFMDVDDIG DFLTFNNLLA DSRYGDESIQ
RAVSILLEKA SAMQDTELTH ALNDSFKRNL SSNVVQWSLW VSCLAQELAS ALKQHCRAGE
FIIKKLKFWP IYVIIKPTKS SSHIFYSLGI RKADVTRRLT GRVFSDTIDA GEWELTEFKS
LKTCKLTNLV NLPCTMLNSI AFWREKLGVA PWLVRKPCSE LREQVGLTFL ISLEDKSKTE
EIITLTRYTQ MEGFVSPPML PKPQKMLGKL EGPLRTKLQV YLLRKHLDCM VRIASQPFSL
IPREGRVEWG GTFHAISGRS TNLENMVNSW YIGYYKNKEE STELNALGEM YKKIVEMEED
KPSSPEFLGW GDTDSPKKHE FSRSFLRAAC SSLEREIAQR HGRQWKQNLE ERVLREIGTK
NILDLASMKA TSNFSKDWEL YSEVQTKEYH RSKLLEKMAT LIEKGVMWYI DAVGQAWKAV
LDDGCMRICL FKKNQHGGLR EIYVMDANAR LVQFGVETMA RCVCELSPHE TVANPRLKNS
IIENHGLKSA RSLGPGSINI NSSNDAKKWN QGHYTTKLAL VLCWFMPAKF HRFIWAAISM
FRRKKMMVDL RFLAHLSSKS ESRSSDPFRE AMTDAFHGNR DVSWMDKGRT YIKTETGMMQ
GILHFTSSLL HSCVQSFYKS YFVSKLKEGY MGESISGVVD VIEGSDDSAI MISIRPKSDM
DEVRSRFFVA NLLHSVKFLN PLFGIYSSEK STVNTVYCVE YNSEFHFHRH LVRPTLRWIA
ASHQISETEA LASRQEDYSN LLTQCLEGGA SFSLTYLIQC AQLLHHYMLL GLCLHPLFGT
FMGMLISDPD PALGFFLMDN PAFAGGAGFR FNLWRACKTT DLGRKYAYYF NEIQGKTKGD
EDYRALDATS GGTLSHSVMV YWGDRKKYQA LLNRMGLPED WVEQIDENPG VLYRRAANKK
ELLLKLAEKV HSPGVTSSLS KGHVVPRVVA AGVYLLSRHC FRFSSSIHGR GSTQKASLIK
LLMMSSISAM KHGGSLNPNQ ERMLFPQAQE YDRVCTLLEE VEHLTGKFVV RERNIVRSRI
DLFQEPVDLR CKAEDLVSEV WFGLKRTKLG PRLLKEEWDK LRASFAWLST DPSETLRDGP
FLSHVQFRNF IAHVDAKSRS VRLLGAPVKK SGGVTTISQV VRMNFFPGFS LEAEKSLDNQ
ERLESISILK HVLFMVLNGP YTEEYKLEMI IEAFSTLVIP QPSEVIRKSR TMTLCLLSNY
LSSRGGSILD QIERAQSGTL GGFSKPQKTF IRPGGGVGYK GKGVWTGVME DTHVQILIDG
DGTSNWLEEI RLSSDARLYD VIESIRRLCD DLGINNRVAS AYRGHCMVRL SGFKIKPASR
TDGCPVRIME RGFRIRELQN PDEVKMRVRG DILNLSVTIQ EGRVMNILSY RPRDTDISES
AAAYLWSNRD LFSFGKKEPS CSWICLKTLD NWAWSHASVL LANDRKTQGI DNRAMGNIFR
DCLEGSLRKQ GLMRSKLTEM VEKNVVPLTT QELVDILEED IDFSDVIAVE LSEGSLDIES
IFDGAPILWS AEVEEFGEGV VAVSYSSKYY HLTLMDQAAI TMCAIMGKEG CRGLLTEKRC
MAAIREQVRP FLIFLQIPED SISWVSDQFC DSRGLDEEST IMWG
//
