ID M9WJS6_9POXV Unreviewed; 564 AA.
AC M9WJS6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Kelch-like protein {ECO:0000313|EMBL:AGJ91654.1};
GN ORFNames=VACV_TT9_232 {ECO:0000313|EMBL:AGJ91654.1};
OS Vaccinia virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10245 {ECO:0000313|EMBL:AGJ91654.1, ECO:0000313|Proteomes:UP000181235};
RN [1] {ECO:0000313|EMBL:AGJ91654.1, ECO:0000313|Proteomes:UP000181235}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tiantan {ECO:0000313|EMBL:AGJ91654.1};
RX PubMed=23593246;
RA Zhang Q., Tian M., Feng Y., Zhao K., Xu J., Liu Y., Shao Y.;
RT "Genomic Sequence and Virulence of Clonal Isolates of Vaccinia Virus
RT Tiantan, the Chinese Smallpox Vaccine Strain.";
RL PLoS ONE 8:E60557-E60557(2013).
CC -!- FUNCTION: Probable substrate-specific adapter of CUL3-containing E3
CC ubiquitin-protein ligases which mediate the ubiquitination and
CC subsequent proteasomal degradation of host target proteins.
CC {ECO:0000256|ARBA:ARBA00003454}.
CC -!- SUBUNIT: Interacts (via BTB domain) with host CUL3.
CC {ECO:0000256|ARBA:ARBA00011677}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
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DR EMBL; JX489136; AGJ91654.1; -; Genomic_DNA.
DR Proteomes; UP000181235; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR024182; Vaccinia_A55R.
DR PANTHER; PTHR45632:SF3; KELCH-LIKE PROTEIN DIABLO; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF003716; VAC_F3L; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022489};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Modulation of host E3 ubiquitin ligases by virus
KW {ECO:0000256|ARBA:ARBA00022489};
KW Modulation of host ubiquitin pathway by virus
KW {ECO:0000256|ARBA:ARBA00022662}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 21..88
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 564 AA; 64835 MW; F2E6BB06C94D9816 CRC64;
MNNSSELIAV INGFRNSGRF CDINIVINDE RINAHKLILS GASEYFSILF SNNFIDSNEY
EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF LQIGSAITEC EKYILKNLCS
RNCIDFYIYA DKYNNKKIES ASFNTILRNI LRLINDENFK YLTEESMIKI LSDDMLNIKN
EDFAPLILIK WLESTQQSCT VELLKCLRIS LLSPQVIKSL YSHRLVSSIY ECITFLNNIA
FLDESFPRYH SIELISIGIS NSRDKISINC YNHKKNTWEM ISSRRYRCSF AVAVLDNIIY
MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GLADDEYIYC IGGIRDQDSS
LTSSIDRWKP SKPYWQKYAK MREPKCDMGV AMLNGLIYVM GGIVKGDTCT DALESLSEDG
WMKHQRLPIK MSNMSTIVHD GKIYISGGYN NSSVVNVISN LVLSYNPIYD EWTKLSSLNI
PRINPALWSA HNKLYVGGGI SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK
HKYPLEKTQY TNDFLKYLES FIGS
//
