GenomeNet

Database: UniProt
Entry: M9WTM7_MANHA
LinkDB: M9WTM7_MANHA
Original site: M9WTM7_MANHA 
ID   M9WTM7_MANHA            Unreviewed;       445 AA.
AC   M9WTM7;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AGK00512.1};
GN   ORFNames=MHH_c00010 {ECO:0000313|EMBL:AGK00512.1};
OS   Mannheimia haemolytica M42548.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Mannheimia.
OX   NCBI_TaxID=1316932 {ECO:0000313|EMBL:AGK00512.1, ECO:0000313|Proteomes:UP000012987};
RN   [1] {ECO:0000313|EMBL:AGK00512.1, ECO:0000313|Proteomes:UP000012987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M42548 {ECO:0000313|EMBL:AGK00512.1,
RC   ECO:0000313|Proteomes:UP000012987};
RX   PubMed=23723408;
RA   Eidam C., Poehlein A., Brenner Michael G., Kadlec K., Liesegang H.,
RA   Brzuszkiewicz E., Daniel R., Sweeney M.T., Murray R.W., Watts J.L.,
RA   Schwarz S.;
RT   "Complete Genome Sequence of Mannheimia haemolytica Strain 42548 from
RT   a Case of Bovine Respiratory Disease.";
RL   Genome Announc. 1:E00318-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP005383; AGK00512.1; -; Genomic_DNA.
DR   RefSeq; WP_006250408.1; NC_021082.1.
DR   ProteinModelPortal; M9WTM7; -.
DR   EnsemblBacteria; AGK00512; AGK00512; MHH_c00010.
DR   GeneID; 15340604; -.
DR   KEGG; mhx:MHH_c00010; -.
DR   PATRIC; fig|1316932.3.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000012987; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000012987};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012987}.
FT   DOMAIN      140    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      353    422       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     148    155       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   445 AA;  50408 MW;  158BDB3EA0456A40 CRC64;
     MSSLWSDCLN HLQTKVSPTD YSTWLRPLQA SSENGELTLY AQNQFVENWV KDKFLSEITE
     LARFLAKNDN LVVTLKVGIK PTEQPKVSPN LKNESSEFSN TGFKTGLNPN QTFDNFVQGR
     SNQLAKLVAQ QVVDNLGESH CNPLSFYAGT GLGKTHLLHA IGNELVKRTP GTRVLYIHLE
     RFYRDIIKAI NSSNNDAEKI KKFYRSLDVL MIDDIQFLAN KPKVQEEFLH LLNALFEQRK
     QIILTSDVLP KNIDKIDTAI KSRLSGGISA TIEPPELETR VAILRQKALE RGADLQEDAA
     YLMGQKLRTN VRELEGALNR VIAWQKLTLR PITVDAVRET LQDLFASFDY LITIENIQRI
     VAEYYGIKVA DIKSKSRARS IARPRQMAMA LAKELTNHSL PEIGREFGGR DHTTVMHACK
     TINELRDTES GIQEDYIHLT RKLSS
//
DBGET integrated database retrieval system