ID M9XD27_MEIRD Unreviewed; 640 AA.
AC M9XD27;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=K649_05890 {ECO:0000313|EMBL:AGK04478.1};
OS Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus
OS ruber).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Meiothermus.
OX NCBI_TaxID=504728 {ECO:0000313|EMBL:AGK04478.1, ECO:0000313|Proteomes:UP000013026};
RN [1] {ECO:0000313|EMBL:AGK04478.1, ECO:0000313|Proteomes:UP000013026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC {ECO:0000313|Proteomes:UP000013026};
RA Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP005385; AGK04478.1; -; Genomic_DNA.
DR AlphaFoldDB; M9XD27; -.
DR STRING; 504728.K649_05890; -.
DR KEGG; mre:K649_05890; -.
DR PATRIC; fig|504728.9.peg.1214; -.
DR eggNOG; COG0210; Bacteria.
DR Proteomes; UP000013026; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 201..466
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 222..229
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 640 AA; 72693 MW; 35475C7D75895156 CRC64;
MERGQIMDAL LSFFQDPSYP SLRLEKIHND FWSIRASRDL RIILTRQAQV WIAAYCGHHD
EAYRWAERRR VEVHPQTGDI QIVRIPEVDT PSREPPANAP LARFDEDYLL SLGVPQDYVK
PLRYATEDGV LELLDGLPQA IQERILDLLD GKPVIPPPKI QVQNAEELLA HPMAQRQFVL
LRSLQEVRQA LQGSWEAWHF FLHPLQQEVV GARFGGPARV TGGAGTGKTV VAIHRARTLA
QRYPQARILL TTFNKGLARK LKVALKGLAG EELPNVWVDH LHNLALRLHE EVAEPVQIWT
EEKYRPILEK LCQGLPYSSG FLLSEWEMAD AWGLYIWEAY RGFSREGRGT PLSARERQAL
FEVFQRVWET LRAQGAATFS GVCHRVRAAL EEGHLPRFRA VVADETQDFG PAELMLLRAL
AEEGEDDLFL TLDPAQRIYR GPTSWRALGL EVQGRSRRLR VNYRTTREIG ELAERTLPSQ
VEGEARGSLA LLRGPTPEQR GFNREEEALK ELLRWVRWLL GQGLEPRQIA VLARVHKLAE
SVGKRLLAEG LPAQKLDEDG EGVWYGTVHA AKGLEFRAVA LFGASADLFP LKILLNKAAD
LQEKALVEEK ERSLLYVALS RPREYLWVGY WGEPSPYLPS
//
