ID MADCA_RAT Reviewed; 394 AA.
AC O70540;
DT 02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-APR-2013, entry version 81.
DE RecName: Full=Mucosal addressin cell adhesion molecule 1;
DE Short=MAdCAM-1;
DE Short=rMAdCAM-1;
DE Flags: Precursor;
GN Name=Madcam1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=WKAH; TISSUE=Lymph node;
RX PubMed=9512658; DOI=10.1016/S0167-4781(97)00142-5;
RA Iizuka T., Koike R., Miyasaka N., Miyasaka M., Watanabe T.;
RT "Cloning and characterization of the rat MAdCAM-1 cDNA and gene.";
RL Biochim. Biophys. Acta 1395:266-270(1998).
CC -!- FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal
CC venules, helps to direct lymphocyte traffic into mucosal tissues
CC including the Peyer patches and the intestinal lamina propria. It
CC can bind both the integrin alpha-4/beta-7 and L-selectin,
CC regulating both the passage and retention of leukocytes (By
CC similarity).
CC -!- SUBUNIT: Homodimer (Probable).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Detected in Peyer patches and mesenteric lymph
CC nodes but not in spleen.
CC -!- SIMILARITY: Contains 3 Ig-like (immunoglobulin-like) domains.
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DR EMBL; D87840; BAA25260.1; -; mRNA.
DR IPI; IPI00199517; -.
DR RefSeq; NP_062190.1; NM_019317.1.
DR UniGene; Rn.87175; -.
DR ProteinModelPortal; O70540; -.
DR SMR; O70540; 20-225.
DR STRING; 10116.ENSRNOP00000010939; -.
DR PRIDE; O70540; -.
DR Ensembl; ENSRNOT00000010938; ENSRNOP00000010939; ENSRNOG00000008217.
DR GeneID; 54266; -.
DR KEGG; rno:54266; -.
DR UCSC; RGD:3029; rat.
DR CTD; 8174; -.
DR RGD; 3029; Madcam1.
DR eggNOG; NOG26033; -.
DR GeneTree; ENSGT00510000049549; -.
DR HOGENOM; HOG000060103; -.
DR HOVERGEN; HBG052394; -.
DR InParanoid; O70540; -.
DR KO; K06779; -.
DR OMA; WELLCEA; -.
DR OrthoDB; EOG4DV5N6; -.
DR NextBio; 610806; -.
DR Genevestigator; O70540; -.
DR GermOnline; ENSRNOG00000008217; Rattus norvegicus.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0007155; P:cell adhesion; IDA:RGD.
DR GO; GO:0016337; P:cell-cell adhesion; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEP:RGD.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Compara.
DR GO; GO:0050900; P:leukocyte migration; IEA:Compara.
DR GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR015169; Adhes-Ig-like.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF09085; Adhes-Ig_like; 1.
DR PRINTS; PR01472; ICAMVCAM1.
DR ProDom; PD336606; Adhes-Ig-like; 1.
DR PROSITE; PS50835; IG_LIKE; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1 19 Potential.
FT CHAIN 20 394 Mucosal addressin cell adhesion molecule
FT 1.
FT /FTId=PRO_0000014855.
FT TOPO_DOM 20 353 Extracellular (Potential).
FT TRANSMEM 354 374 Helical; (Potential).
FT TOPO_DOM 375 394 Cytoplasmic (Potential).
FT DOMAIN 20 107 Ig-like 1.
FT DOMAIN 108 225 Ig-like 2.
FT DOMAIN 256 345 Ig-like 3.
FT REGION 219 255 Mucin-like.
FT CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
FT DISULFID 43 89 By similarity.
FT DISULFID 47 93 By similarity.
FT DISULFID 130 198 By similarity.
FT DISULFID 282 330 Potential.
SQ SEQUENCE 394 AA; 42507 MW; 3D99490007E7421C CRC64;
MEPILALLLA LGPFQLSRGQ SFQVNPPEPE VAVAMGTSLQ INCSMSCDKD IARVHWHGLD
TNLGNVQTLP GSRVLSVRGM LSDTGTRVCV GSCGSRSFQH SVKILVYAFP DQLEVTPEFL
VPGRDQVVSC TAHNIWPAGP DSLSFALLRG EQSLEGAQAL ETEQEEEMQE TEGTPLFQVT
QRWLLPSLGT PALPALYCQV TMQLPKLVLT HRRKIPVLQS QTSPEPPSTT SAKPYILTSS
HTTKAVSTGL SSVALPSTPL SSEGPCYPEI HQNPEADWEL LCEASCGSGV TVHWTLAPGD
LAAYHKREAG AQAWLSVLPL GPIPEGWFQC RMDPGGQVTS LYVTGQVIPN PSSMVALWIG
SLVLGLLALA FLAYCLWKRY RPGPLPDSSS CTLL
//
