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Database: UniProt
Entry: MADCA_RAT
LinkDB: MADCA_RAT
Original site: MADCA_RAT 
ID   MADCA_RAT               Reviewed;         394 AA.
AC   O70540;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   09-JUL-2014, entry version 90.
DE   RecName: Full=Mucosal addressin cell adhesion molecule 1;
DE            Short=MAdCAM-1;
DE            Short=rMAdCAM-1;
DE   Flags: Precursor;
GN   Name=Madcam1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=WKAH; TISSUE=Lymph node;
RX   PubMed=9512658; DOI=10.1016/S0167-4781(97)00142-5;
RA   Iizuka T., Koike R., Miyasaka N., Miyasaka M., Watanabe T.;
RT   "Cloning and characterization of the rat MAdCAM-1 cDNA and gene.";
RL   Biochim. Biophys. Acta 1395:266-270(1998).
CC   -!- FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal
CC       venules, helps to direct lymphocyte traffic into mucosal tissues
CC       including the Peyer patches and the intestinal lamina propria. It
CC       can bind both the integrin alpha-4/beta-7 and L-selectin,
CC       regulating both the passage and retention of leukocytes (By
CC       similarity).
CC   -!- SUBUNIT: Homodimer (Probable).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Detected in Peyer patches and mesenteric lymph
CC       nodes but not in spleen.
CC   -!- SIMILARITY: Contains 3 Ig-like (immunoglobulin-like) domains.
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DR   EMBL; D87840; BAA25260.1; -; mRNA.
DR   RefSeq; NP_062190.1; NM_019317.1.
DR   RefSeq; XP_006241048.1; XM_006240986.1.
DR   UniGene; Rn.87175; -.
DR   ProteinModelPortal; O70540; -.
DR   SMR; O70540; 20-225.
DR   MINT; MINT-4996260; -.
DR   STRING; 10116.ENSRNOP00000010939; -.
DR   PRIDE; O70540; -.
DR   Ensembl; ENSRNOT00000010938; ENSRNOP00000010939; ENSRNOG00000008217.
DR   GeneID; 54266; -.
DR   KEGG; rno:54266; -.
DR   UCSC; RGD:3029; rat.
DR   CTD; 8174; -.
DR   RGD; 3029; Madcam1.
DR   eggNOG; NOG26033; -.
DR   GeneTree; ENSGT00510000049549; -.
DR   HOGENOM; HOG000060103; -.
DR   HOVERGEN; HBG052394; -.
DR   InParanoid; O70540; -.
DR   KO; K06779; -.
DR   OMA; WELLCEA; -.
DR   OrthoDB; EOG7FR7HJ; -.
DR   PhylomeDB; O70540; -.
DR   TreeFam; TF337571; -.
DR   NextBio; 610806; -.
DR   PRO; PR:O70540; -.
DR   Genevestigator; O70540; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007568; P:aging; IEP:RGD.
DR   GO; GO:0007155; P:cell adhesion; IDA:RGD.
DR   GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR   GO; GO:0050900; P:leukocyte migration; IEA:Ensembl.
DR   GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD.
DR   GO; GO:0016337; P:single organismal cell-cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR015169; Adhes-Ig-like.
DR   InterPro; IPR003987; ICAM_VCAM_N.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF09085; Adhes-Ig_like; 1.
DR   PRINTS; PR01472; ICAMVCAM1.
DR   ProDom; PD336606; Adhes-Ig-like; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     19       Potential.
FT   CHAIN        20    394       Mucosal addressin cell adhesion molecule
FT                                1.
FT                                /FTId=PRO_0000014855.
FT   TOPO_DOM     20    353       Extracellular (Potential).
FT   TRANSMEM    354    374       Helical; (Potential).
FT   TOPO_DOM    375    394       Cytoplasmic (Potential).
FT   DOMAIN       20    107       Ig-like 1.
FT   DOMAIN      108    225       Ig-like 2.
FT   DOMAIN      256    345       Ig-like 3.
FT   REGION      219    255       Mucin-like.
FT   CARBOHYD     42     42       N-linked (GlcNAc...) (Potential).
FT   DISULFID     43     89       By similarity.
FT   DISULFID     47     93       By similarity.
FT   DISULFID    130    198       By similarity.
FT   DISULFID    282    330       Potential.
SQ   SEQUENCE   394 AA;  42507 MW;  3D99490007E7421C CRC64;
     MEPILALLLA LGPFQLSRGQ SFQVNPPEPE VAVAMGTSLQ INCSMSCDKD IARVHWHGLD
     TNLGNVQTLP GSRVLSVRGM LSDTGTRVCV GSCGSRSFQH SVKILVYAFP DQLEVTPEFL
     VPGRDQVVSC TAHNIWPAGP DSLSFALLRG EQSLEGAQAL ETEQEEEMQE TEGTPLFQVT
     QRWLLPSLGT PALPALYCQV TMQLPKLVLT HRRKIPVLQS QTSPEPPSTT SAKPYILTSS
     HTTKAVSTGL SSVALPSTPL SSEGPCYPEI HQNPEADWEL LCEASCGSGV TVHWTLAPGD
     LAAYHKREAG AQAWLSVLPL GPIPEGWFQC RMDPGGQVTS LYVTGQVIPN PSSMVALWIG
     SLVLGLLALA FLAYCLWKRY RPGPLPDSSS CTLL
//
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