ID MALR_STRPN Reviewed; 328 AA.
AC P0A4T1; Q08511;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=HTH-type transcriptional regulator MalR;
DE AltName: Full=Maltose operon transcriptional repressor;
GN Name=malR; OrderedLocusNames=SP_2112;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
CC -!- FUNCTION: Transcriptional repressor of the maltosaccharide utilization
CC operons malxCD and malMP. {ECO:0000250}.
CC -!- INTERACTION:
CC P0A4T1; P95830: dnaJ; NbExp=2; IntAct=EBI-2207435, EBI-2207079;
CC P0A4T1; Q97SE5: gatC; NbExp=2; IntAct=EBI-2207435, EBI-2207053;
CC P0A4T1; Q97NV3: groES; NbExp=2; IntAct=EBI-2207435, EBI-2206949;
CC P0A4T1; P05382: sulA; NbExp=2; IntAct=EBI-2207435, EBI-2206997;
CC P0A4T1; Q97SR4: uppS; NbExp=2; IntAct=EBI-2207435, EBI-2206983;
CC P0A4T1; Q97QP2: xerS; NbExp=2; IntAct=EBI-2207435, EBI-2207218;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005672; AAK76171.1; -; Genomic_DNA.
DR PIR; B49543; B49543.
DR PIR; B95247; B95247.
DR RefSeq; WP_001145439.1; NZ_CP089948.1.
DR AlphaFoldDB; P0A4T1; -.
DR SMR; P0A4T1; -.
DR IntAct; P0A4T1; 6.
DR PaxDb; 170187-SP_2112; -.
DR EnsemblBacteria; AAK76171; AAK76171; SP_2112.
DR GeneID; 66807191; -.
DR KEGG; spn:SP_2112; -.
DR eggNOG; COG1609; Bacteria.
DR BioCyc; SPNE170187:G1FZB-2200-MONOMER; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06294; PBP1_MalR-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF121; HTH-TYPE TRANSCRIPTIONAL REPRESSOR CYTR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF00532; Peripla_BP_1; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..328
FT /note="HTH-type transcriptional regulator MalR"
FT /id="PRO_0000107971"
FT DOMAIN 2..57
FT /note="HTH lacI-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT DNA_BIND 5..24
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT REGION 173..218
FT /note="Inducer binding"
FT /evidence="ECO:0000255"
FT REGION 282..291
FT /note="Dimerization"
FT /evidence="ECO:0000255"
SQ SEQUENCE 328 AA; 37044 MW; 0D8026C93ECB232D CRC64;
MPVTIKDVAK AAGVSPSTVT RVIQNKSTIS DETKKRVRKA MKELNYHPNL NARSLVSSYT
QVIGLVLPDD SDAFYQNPFF PSVLRGISQV ASENHYAIQI ATGKDEKERL NAISQMVYGK
RVDGLIFLYA QEEDPLVKLV AEEQFPFLIL GKSLSPFIPL VDNDNVQAGF DATEYFIKKG
CKRIAFIGGS KKLFVTKDRL TGYEQALKHY KLTTDNNRIY FADEFLEEKG YKFSKRLFKH
DPQIDAIITT DSLLAEGVCN YIAKHQLDVP VLSFDSVNPK LNLAAYVDIN SLELGRVSLE
TILQIINDNK NNKQICYRQL IAHKIIEK
//
