ID MATA1_KLULA Reviewed; 228 AA.
AC Q9HG12; Q6CV60;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Mating-type protein A1;
DE AltName: Full=A1 transcription factor;
DE AltName: Full=MATa1 protein;
GN Name=MATA1; Synonyms=a1; OrderedLocusNames=KLLA0C03135g;
GN and
GN Name=HMRA1; OrderedLocusNames=KLLA0B14553g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10978277; DOI=10.1093/genetics/156.1.81;
RA Aastroem S.U., Kegel A., Sjoestrand J.O.O., Rine J.;
RT "Kluyveromyces lactis Sir2p regulates cation sensitivity and maintains a
RT specialized chromatin structure at the cryptic alpha-locus.";
RL Genetics 156:81-91(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion.
CC Transcriptional corepressor that acts in conjunction with ALPHA2 to
CC repress transcription of haploid-specific genes (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Forms a heterodimer with ALPHA2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC K.lactis. MAT is the expression locus that determines the mating type
CC of the cell, whereas HML (containing HMLALPHA1, HMLALPHA2 and
CC HMLALPHA3) and HMR (containing HMRA1 and HMRA2) represent silenced
CC repositories of mating type information. The mating type is determined
CC by the MAT locus, which contains either a copy of HML or of HMR.
CC Diploid cells are usually heterozygous for the MAT locus.
CC -!- SIMILARITY: Belongs to the MATA1 family. {ECO:0000305}.
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DR EMBL; AF195067; AAG21094.1; -; Genomic_DNA.
DR EMBL; AJ617304; CAE84411.1; -; Genomic_DNA.
DR EMBL; CR382122; CAH02572.1; -; Genomic_DNA.
DR EMBL; CR382123; CAH01188.1; -; Genomic_DNA.
DR RefSeq; XP_452179.1; XM_452179.1.
DR RefSeq; XP_452337.1; XM_452337.1.
DR AlphaFoldDB; Q9HG12; -.
DR SMR; Q9HG12; -.
DR STRING; 284590.Q9HG12; -.
DR PaxDb; 284590-Q9HG12; -.
DR GeneID; 2892130; -.
DR GeneID; 2897450; -.
DR KEGG; kla:KLLA0_B14553g; -.
DR KEGG; kla:KLLA0_C03135g; -.
DR eggNOG; ENOG502SCEX; Eukaryota.
DR HOGENOM; CLU_1214931_0_0_1; -.
DR InParanoid; Q9HG12; -.
DR Proteomes; UP000000598; Chromosome B.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR24339; HOMEOBOX PROTEIN EMX-RELATED; 1.
DR PANTHER; PTHR24339:SF28; HOMEOBOX PROTEIN NOTOCHORD; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..228
FT /note="Mating-type protein A1"
FT /id="PRO_0000049179"
FT DNA_BIND 155..214
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 120..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 228 AA; 26553 MW; DAE864F5E1190BB6 CRC64;
MCDNDMADIQ SKLSSFCEEI RALALKEGYN LEGDKSPSSK PYFMSWPKEI DVNHPNFAFF
TKLQFQYDKS LETILNSCYL QELQLDPTRI IETLQQHFNN SILRYADIEN ISDVKDESPM
SFDTEHECTD TSEDISDKSE ISSTNSDNPI QNCYPTYKRS FIKHESRGIL EKIFKVKQCP
NTSERLYIAQ KLDLTPSQVR IWFTNKRMRA KKHTTGKGTK RKSKKYPS
//
