ID MED1_AEDAE Reviewed; 1760 AA.
AC Q172G3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 1;
DE AltName: Full=Mediator complex subunit 1;
GN ORFNames=AAEL007402;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC {ECO:0000305}.
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DR EMBL; CH477438; EAT40905.1; -; Genomic_DNA.
DR RefSeq; XP_001652740.1; XM_001652690.1.
DR AlphaFoldDB; Q172G3; -.
DR STRING; 7159.Q172G3; -.
DR PaxDb; 7159-AAEL007402-PA; -.
DR VEuPathDB; VectorBase:AAEL028220; -.
DR eggNOG; ENOG502QPZ7; Eukaryota.
DR HOGENOM; CLU_004475_0_0_1; -.
DR InParanoid; Q172G3; -.
DR OMA; FDDPPRM; -.
DR PhylomeDB; Q172G3; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR InterPro; IPR019680; Mediator_Med1.
DR PANTHER; PTHR12881; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR PANTHER; PTHR12881:SF10; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1; 1.
DR Pfam; PF10744; Med1; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1760
FT /note="Mediator of RNA polymerase II transcription subunit
FT 1"
FT /id="PRO_0000302022"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1455..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1540..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..685
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1058
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1540..1573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1589..1640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1760 AA; 181862 MW; EDA31A08993BACC9 CRC64;
MSSIHSKVVI GEKRREMSST AAGGSLPASI MANGSGKPIK MEMKPIVGTT AAGKGHGGLL
PGSGDKHESW QMELLMERLR NKAKSSQYKS FQEMSKAVRM SLLEKRYALD AVEKSNLQKT
LDSMQYCIKV TSRQGLVERL DCLTRQLGLK LSEDTSGLFI SSDMFYLEII LDPNGTVQDV
KVHHECKMKQ QSCSELVSCL QRGDFVDFTT QLEGLASIYQ LNAEKKIKVN AFVALQALET
DLYNLYTLST QHYNDIHSLL LKSPLGVVQK RRGGHAMKLT YYIAPYDLLD LEARKMKPLN
TELISAEKIG YSVAVNLEAS TANKLQIQPL LVQQGNSPVY SPIEKHNSTS LPATFVLRLN
KPMALNVAML KQIKHITGDS SAVTIDPATS NTCLMSLIVQ HASNGTVNNI AKGLFVTLPD
QYHCYYMTEN KNLQGTIISS IPFTEPQHVS KILVFLRQQA LFNQLLTSCI RNNGSSSTRM
SDYEHLVVFE VAALSCQYIT VSLEHPFEES IAMVEFDLRN ILAIQVRVFC NGYESDERIS
KQVSLIVQRT MSIPVTLRGL MKIWQEDYEV KFKGQGNGGG NGTVDEGNFS LSMGPDEGGG
NGPAGPGGGG GGGSAMNGQH NGSLNGSGME FCDVKKVKLE PMDQSKKRRG VEDFCRSPKS
SKVESEGGNE AMDEEDDDDE YDESTNLSSG DSNSLGENQQ TNAGQSSSST AAMGAPAPVS
TVGPRNSVSG NASESSGNSS ILGSLDFSSL DPDLMRSSNS SDLDDTTEVS EPEVKVKSEE
PSYATSVSIT PIGVGKSTSS LTNSVLNNIG LDKRPGIEII PLANAGTNVP SSITITPIPM
GSSGGSLKSS SDNSGDKKLS SSSSGSIHRK SGSSSSSSES DRAKLEKKKK RRHEEQLAQL
QQMGPPHKIL SKSTDGPASP SGSSRKFSVS PVPLKSGSGS SSSQIFLSSG SPGSGSKSSP
KHSPVHHSSP KHQGSYGTSS PKHISGGSSG GGKPSMSALK SATSSGSPSS KNGSSGIGGS
GKEEGSSGSG SKSSGSGGSS SSRDRDRDRD RDRGEKRSGY SSSSSSSSPK LKTPAVKLKQ
LDLTNCGSTV SAGVQLELMN SNSSGGSSSG SGSIDLTDSA LFGIGATDLS KNASAAAASA
AGMLLLQQAM KRKGSLSAVI DKLKSAQGGD ESSLMLLPEL AQQAGFSLKD ASTPGKTASS
SLPVASSSSA SSSTSSTSVS NLTGASLGSA SAAAAAALAA HFSSAAAAMQ GKTSEYMVKP
SSDGIKLTIQ NKKGSKSGSS SSSTSSSSSK SSSSKSGTKP SISSGSLPPK KLPSSQSFSG
AYPPTSGSSS SSSGKSFSSG SSSSSSSKAP FQKSSSSGSL SSSGSSMRPS SKSSTSSSGS
SKDKSRSSSK SSSSSSAAAA AASSLMATNA AMAAAAQAAV NANALNVMKM LGLTSSIQNM
EGFVKTLDTK FQIPKLSARS GGSSGSGPGG SDIEKLKQES RPLSSSSAPT TPLSNVGQSP
TGSNDFSLPF NKLPGDVSPL HSTLLPNVMQ KMFSGHDTSM LMRRSPNLDH QSSSNSRDGF
SSIYGKGSTT PTTPTGSVPP PFPSPGNVQS HAMDFSNSSD SADASLMRPP SRPSSTMSNH
SSSDKLIDAT TNSNSMDGLR STSPAQALAA AAVAAQLMNK LDNTQQFVAA LKNHHHHLSA
LSLSNAAAVA ASQLAAAAAS ASSGGSAGPG PVTSPTSVSV HIMKSPVPSP LPLHGGGGAA
SSSSVGGPDE DETLVGVSGK
//
