ID MO2R1_BOVIN Reviewed; 355 AA.
AC A5D7V5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Cell surface glycoprotein CD200 receptor 1;
DE AltName: Full=CD200 cell surface glycoprotein receptor;
DE AltName: Full=Cell surface glycoprotein OX2 receptor 1;
DE Flags: Precursor;
GN Name=CD200R1; Synonyms=CD200R;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibitory receptor for the CD200/OX2 cell surface
CC glycoprotein. Limits inflammation by inhibiting the expression of pro-
CC inflammatory molecules including TNF-alpha, interferons, and inducible
CC nitric oxide synthase (iNOS) in response to selected stimuli (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: CD200 and CD200R1 interact via their respective N-terminal Ig-
CC like domains. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD200R family. {ECO:0000305}.
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DR EMBL; BC140695; AAI40696.1; -; mRNA.
DR RefSeq; NP_001092844.1; NM_001099374.2.
DR AlphaFoldDB; A5D7V5; -.
DR SMR; A5D7V5; -.
DR STRING; 9913.ENSBTAP00000001635; -.
DR GlyCosmos; A5D7V5; 3 sites, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000001635; -.
DR Ensembl; ENSBTAT00000001635.6; ENSBTAP00000001635.5; ENSBTAG00000001235.6.
DR GeneID; 516008; -.
DR KEGG; bta:516008; -.
DR VEuPathDB; HostDB:ENSBTAG00000001235; -.
DR eggNOG; ENOG502SPS1; Eukaryota.
DR GeneTree; ENSGT00390000014496; -.
DR HOGENOM; CLU_069156_0_0_1; -.
DR InParanoid; A5D7V5; -.
DR OMA; MKAGTNM; -.
DR OrthoDB; 5358420at2759; -.
DR TreeFam; TF335960; -.
DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000001235; Expressed in monocyte and 85 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0150077; P:regulation of neuroinflammatory response; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR040012; CD200R.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR21462:SF2; CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1; 1.
DR PANTHER; PTHR21462; CELL SURFACE GLYCOPROTEIN OX2 RECEPTOR PRECURSOR; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..355
FT /note="Cell surface glycoprotein CD200 receptor 1"
FT /id="PRO_0000346449"
FT TOPO_DOM 27..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 139..257
FT /note="Ig-like C2-type"
FT REGION 35..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..156
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 108..124
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 191..241
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 210..229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 355 AA; 39220 MW; AC9FD1D78B480F42 CRC64;
MPCTWITSDL QLRLILTLFF VAECLSAGME GTKTSNNSMQ QLDNGNHSSV STTSSTERKQ
STVTLYAEVK TSLSVLVDTK AVLTCPPVLW PSVLVVTWEI VLRDKPPCFG AYRRDTNQTT
RGNCTDKRIT WASRPDENPA LQVDPVAITH DGNYTCQIVT SDGNFHHEYH LQVLVPPEVT
LIQTEKGTAV CKAAAGKPAA QISWTPEGDC DTEQGPYWGD GTVTVQSTCR WGSRHVLNVS
CSVSHLAGNK SLSIQLSQGA EIPAHLKNLY ITAPIFIILI VVGSIWLLKI SGCRKCKLKK
TEHTPVVQED EMEPYASYTE KNNPLYDITN RVKTSQVLQS EVDGMNLHTI YVPRV
//
