ID MSXA_DANRE Reviewed; 257 AA.
AC Q03357;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Homeobox protein MSH-A;
GN Name=msxa; Synonyms=msh-a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=7768177; DOI=10.1242/dev.121.2.347;
RA Akimenko M.-A., Johnson S.L., Westerfield M., Ekker M.;
RT "Differential induction of four msx homeobox genes during fin development
RT and regeneration in zebrafish.";
RL Development 121:347-357(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-181.
RX PubMed=1673109; DOI=10.1016/0378-1119(91)90182-b;
RA Holland P.W.H.;
RT "Cloning and evolutionary analysis of msh-like homeobox genes from mouse,
RT zebrafish and ascidian.";
RL Gene 98:253-257(1991).
CC -!- FUNCTION: Probable morphogenetic role.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR EMBL; U16310; AAA99705.1; -; mRNA.
DR EMBL; M38578; AAA50031.1; -; Genomic_DNA.
DR PIR; PS0408; PS0408.
DR AlphaFoldDB; Q03357; -.
DR SMR; Q03357; -.
DR STRING; 7955.ENSDARP00000132799; -.
DR PaxDb; 7955-ENSDARP00000073690; -.
DR AGR; ZFIN:ZDB-GENE-980526-322; -.
DR ZFIN; ZDB-GENE-980526-322; msx2a.
DR eggNOG; KOG0492; Eukaryota.
DR InParanoid; Q03357; -.
DR PRO; PR:Q03357; -.
DR Proteomes; UP000000437; Genome assembly.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24338; HOMEOBOX PROTEIN MSX; 1.
DR PANTHER; PTHR24338:SF9; HOMEOBOX PROTEIN MSX-3; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..257
FT /note="Homeobox protein MSH-A"
FT /id="PRO_0000049066"
FT DNA_BIND 122..181
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 18..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 29117 MW; 01DE43D38CBD2539 CRC64;
MVLTQNVDTF SGMISANHKS KVSSDEDDDD HGSRSVRTQS LPFSVDALMS TKERSESTSQ
GSIHMTRIIN QDDRSIYSDS VDFIKRRESA KEDSAWINKP RLSTSPRSQS PTICPLRKHK
TNRKPRTPFT TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL
QEAELERFKM ASKPILHPGL TLPFPLCTQP QTAALVCGQS FPFSRHMLPF APIGIYSTPM
GYSMCHLSKD GYSVEPV
//
