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Database: UniProt
Entry: MT1X_HUMAN
LinkDB: MT1X_HUMAN
Original site: MT1X_HUMAN 
ID   MT1X_HUMAN              Reviewed;          61 AA.
AC   P80297; A8MUC7;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   29-OCT-2014, entry version 123.
DE   RecName: Full=Metallothionein-1X;
DE            Short=MT-1X;
DE   AltName: Full=Metallothionein-IX;
DE            Short=MT-IX;
GN   Name=MT1X;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Soumillion A., van Weyenbergh J., de Ley M.;
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Liver;
RA   Hunziker P.E.;
RL   Submitted (NOV-1993) to UniProtKB.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Placenta;
RX   PubMed=8049263; DOI=10.1016/0167-4781(94)90189-9;
RA   Stennard F.A., Holloway A.F., Hamilton J., West A.K.;
RT   "Characterisation of six additional human metallothionein genes.";
RL   Biochim. Biophys. Acta 1218:357-365(1994).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-31.
RX   PubMed=8119276; DOI=10.1111/j.1432-1033.1994.tb18603.x;
RA   Pauwels M., van Weyenbergh J., Soumillion A., Proost P., Ley M.;
RT   "Induction by zinc of specific metallothionein isoforms in human
RT   monocytes.";
RL   Eur. J. Biochem. 220:105-110(1994).
RN   [7]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA   Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT   a refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine
CC       residues that bind various heavy metals; these proteins are
CC       transcriptionally regulated by both heavy metals and
CC       glucocorticoids.
CC   -!- SUBUNIT: Monomer.
CC   -!- DOMAIN: Class I metallothioneins contain 2 metal-binding domains:
CC       four divalent ions are chelated within cluster A of the alpha
CC       domain and are coordinated via cysteinyl thiolate bridges to 11
CC       cysteine ligands. Cluster B, the corresponding region within the
CC       beta domain, can ligate three divalent ions to 9 cysteines.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1
CC       family. {ECO:0000305}.
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DR   EMBL; X76717; CAA54136.1; -; mRNA.
DR   EMBL; X65607; CAA46557.1; -; Genomic_DNA.
DR   EMBL; AC026461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC032338; AAH32338.1; -; mRNA.
DR   EMBL; S68956; AAB30084.1; -; mRNA.
DR   CCDS; CCDS10768.1; -.
DR   PIR; S47652; S47652.
DR   RefSeq; NP_005943.1; NM_005952.3.
DR   UniGene; Hs.374950; -.
DR   ProteinModelPortal; P80297; -.
DR   SMR; P80297; 1-61.
DR   BioGrid; 110607; 6.
DR   STRING; 9606.ENSP00000377995; -.
DR   PhosphoSite; P80297; -.
DR   MaxQB; P80297; -.
DR   PaxDb; P80297; -.
DR   PRIDE; P80297; -.
DR   DNASU; 4501; -.
DR   Ensembl; ENST00000394485; ENSP00000377995; ENSG00000187193.
DR   GeneID; 4501; -.
DR   KEGG; hsa:4501; -.
DR   UCSC; uc002ejy.3; human.
DR   CTD; 4501; -.
DR   GeneCards; GC16P056719; -.
DR   HGNC; HGNC:7405; MT1X.
DR   MIM; 156359; gene.
DR   neXtProt; NX_P80297; -.
DR   PharmGKB; PA31213; -.
DR   eggNOG; NOG327133; -.
DR   GeneTree; ENSGT00730000110883; -.
DR   HOGENOM; HOG000236262; -.
DR   HOVERGEN; HBG094464; -.
DR   InParanoid; P80297; -.
DR   KO; K14739; -.
DR   OMA; ETECCIS; -.
DR   OrthoDB; EOG7PZS1X; -.
DR   PhylomeDB; P80297; -.
DR   TreeFam; TF336054; -.
DR   ChiTaRS; MT1X; human.
DR   GeneWiki; MT1X; -.
DR   GenomeRNAi; 4501; -.
DR   NextBio; 17402; -.
DR   PRO; PR:P80297; -.
DR   Bgee; P80297; -.
DR   CleanEx; HS_MT1X; -.
DR   ExpressionAtlas; P80297; baseline and differential.
DR   Genevestigator; P80297; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; TAS:ProtInc.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   GO; GO:0071276; P:cellular response to cadmium ion; IEP:UniProtKB.
DR   GO; GO:0036018; P:cellular response to erythropoietin; IEP:UniProtKB.
DR   GO; GO:0071294; P:cellular response to zinc ion; IEP:UniProtKB.
DR   GO; GO:0045926; P:negative regulation of growth; ISS:UniProtKB.
DR   GO; GO:0010038; P:response to metal ion; TAS:ProtInc.
DR   Gene3D; 4.10.10.10; -; 1.
DR   InterPro; IPR017854; Metalthion_dom.
DR   InterPro; IPR023587; Metalthion_dom_vert.
DR   InterPro; IPR003019; Metalthion_sfam_euk.
DR   InterPro; IPR000006; Metalthion_vert.
DR   InterPro; IPR018064; Metalthion_vert_metal_BS.
DR   PANTHER; PTHR23299; PTHR23299; 1.
DR   Pfam; PF00131; Metallothio; 1.
DR   PRINTS; PR00860; MTVERTEBRATE.
DR   SUPFAM; SSF57868; SSF57868; 1.
DR   PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cadmium; Complete proteome; Copper;
KW   Direct protein sequencing; Metal-binding; Metal-thiolate cluster;
KW   Reference proteome; Zinc.
FT   CHAIN         1     61       Metallothionein-1X.
FT                                /FTId=PRO_0000197243.
FT   REGION        1     29       Beta.
FT   REGION       30     61       Alpha.
FT   METAL         5      5       Divalent metal cation; cluster B.
FT   METAL         7      7       Divalent metal cation; cluster B.
FT   METAL        13     13       Divalent metal cation; cluster B.
FT   METAL        15     15       Divalent metal cation; cluster B.
FT   METAL        19     19       Divalent metal cation; cluster B.
FT   METAL        21     21       Divalent metal cation; cluster B.
FT   METAL        24     24       Divalent metal cation; cluster B.
FT   METAL        26     26       Divalent metal cation; cluster B.
FT   METAL        29     29       Divalent metal cation; cluster B.
FT   METAL        33     33       Divalent metal cation; cluster A.
FT   METAL        34     34       Divalent metal cation; cluster A.
FT   METAL        36     36       Divalent metal cation; cluster A.
FT   METAL        37     37       Divalent metal cation; cluster A.
FT   METAL        41     41       Divalent metal cation; cluster A.
FT   METAL        44     44       Divalent metal cation; cluster A.
FT   METAL        48     48       Divalent metal cation; cluster A.
FT   METAL        50     50       Divalent metal cation; cluster A.
FT   METAL        57     57       Divalent metal cation; cluster A.
FT   METAL        59     59       Divalent metal cation; cluster A.
FT   METAL        60     60       Divalent metal cation; cluster A.
FT   MOD_RES       1      1       N-acetylmethionine.
FT                                {ECO:0000269|PubMed:19413330,
FT                                ECO:0000269|PubMed:8119276}.
SQ   SEQUENCE   61 AA;  6068 MW;  381966F942E986B2 CRC64;
     MDPNCSCSPV GSCACAGSCK CKECKCTSCK KSCCSCCPVG CAKCAQGCIC KGTSDKCSCC
     A
//
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