ID MTA_COLVI Reviewed; 43 AA.
AC P27086;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-APR-2013, entry version 63.
DE RecName: Full=Metallothionein A;
DE Short=MTA;
DE Flags: Fragment;
OS Colinus virginianus (Bobwhite quail) (Tetrao virginianus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC Neognathae; Galliformes; Odontophoridae; Colinus.
OX NCBI_TaxID=9014;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8483164; DOI=10.1007/BF00160481;
RA Shartzer K.L., Kage K., Sobieski R.J., Andrews G.K.;
RT "Evolution of avian metallothionein: DNA sequence analyses of the
RT turkey metallothionein gene and metallothionein cDNAs from pheasant
RT and quail.";
RL J. Mol. Evol. 36:255-262(1993).
CC -!- FUNCTION: Metallothioneins have a high content of cysteine
CC residues that bind various heavy metals.
CC -!- DOMAIN: Class I metallothioneins contain 2 metal-binding domains:
CC four divalent ions are chelated within cluster A of the alpha
CC domain and are coordinated via cysteinyl thiolate bridges to 11
CC cysteine ligands. Cluster B, the corresponding region within the
CC beta domain, can ligate three divalent ions to 9 cysteines.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1
CC family.
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DR EMBL; X62511; CAA44370.1; -; mRNA.
DR PIR; S33378; S18173.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 4.10.10.10; -; 1.
DR InterPro; IPR017854; Metalthion_dom.
DR InterPro; IPR023587; Metalthion_dom_vert.
DR InterPro; IPR003019; Metalthion_sfam_euk.
DR InterPro; IPR000006; Metalthion_vert.
DR PANTHER; PTHR23299; PTHR23299; 1.
DR Pfam; PF00131; Metallothio; 1.
DR PRINTS; PR00860; MTVERTEBRATE.
DR SUPFAM; SSF57868; Metallothionein_sfam; 1.
DR PROSITE; PS00203; METALLOTHIONEIN_VRT; PARTIAL.
PE 3: Inferred from homology;
KW Metal-binding; Metal-thiolate cluster.
FT CHAIN <1 >43 Metallothionein A.
FT /FTId=PRO_0000197263.
FT REGION <1 16 Beta.
FT REGION 17 >43 Alpha.
FT METAL 2 2 Divalent metal cation; cluster B.
FT METAL 6 6 Divalent metal cation; cluster B.
FT METAL 8 8 Divalent metal cation; cluster B.
FT METAL 11 11 Divalent metal cation; cluster B.
FT METAL 13 13 Divalent metal cation; cluster B.
FT METAL 16 16 Divalent metal cation; cluster B.
FT METAL 20 20 Divalent metal cation; cluster A.
FT METAL 21 21 Divalent metal cation; cluster A.
FT METAL 23 23 Divalent metal cation; cluster A.
FT METAL 24 24 Divalent metal cation; cluster A.
FT METAL 28 28 Divalent metal cation; cluster A.
FT METAL 31 31 Divalent metal cation; cluster A.
FT METAL 35 35 Divalent metal cation; cluster A.
FT METAL 37 37 Divalent metal cation; cluster A.
FT NON_TER 1 1
FT NON_TER 43 43
SQ SEQUENCE 43 AA; 4401 MW; 1612EB52656EB875 CRC64;
SCAGSCKCKN CRCRSCRKSC CSCCPAGCNN CAKGCVCKEP ASS
//
