ID MTX1_DROME Reviewed; 327 AA.
AC Q9VHB6;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 157.
DE RecName: Full=Metaxin-1 homolog;
DE AltName: Full=Mitochondrial outer membrane import complex protein 1;
GN ORFNames=CG9393;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC organizing system (MICOS) complex (also known as MINOS or MitOS
CC complex). {ECO:0000250|UniProtKB:Q13505}.
CC -!- INTERACTION:
CC Q9VHB6; Q8T4F2: Dmel\CG5662; NbExp=4; IntAct=EBI-158722, EBI-133471;
CC Q9VHB6; Q9VW58: Dmel\CG8004; NbExp=4; IntAct=EBI-158722, EBI-124763;
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54402.1; -; Genomic_DNA.
DR EMBL; AY051682; AAK93106.1; -; mRNA.
DR RefSeq; NP_649908.1; NM_141651.3.
DR AlphaFoldDB; Q9VHB6; -.
DR SMR; Q9VHB6; -.
DR BioGRID; 66311; 4.
DR DIP; DIP-23833N; -.
DR IntAct; Q9VHB6; 3.
DR STRING; 7227.FBpp0081591; -.
DR PaxDb; 7227-FBpp0081591; -.
DR DNASU; 41152; -.
DR EnsemblMetazoa; FBtr0082113; FBpp0081591; FBgn0037710.
DR GeneID; 41152; -.
DR KEGG; dme:Dmel_CG9393; -.
DR UCSC; CG9393-RA; d. melanogaster.
DR AGR; FB:FBgn0037710; -.
DR FlyBase; FBgn0037710; CG9393.
DR VEuPathDB; VectorBase:FBgn0037710; -.
DR eggNOG; KOG3028; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR InParanoid; Q9VHB6; -.
DR OMA; QHIMSCP; -.
DR OrthoDB; 2897805at2759; -.
DR PhylomeDB; Q9VHB6; -.
DR BioGRID-ORCS; 41152; 1 hit in 3 CRISPR screens.
DR GenomeRNAi; 41152; -.
DR PRO; PR:Q9VHB6; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037710; Expressed in testis and 27 other cell types or tissues.
DR ExpressionAtlas; Q9VHB6; baseline and differential.
DR Genevisible; Q9VHB6; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:FlyBase.
DR GO; GO:0001401; C:SAM complex; ISS:FlyBase.
DR GO; GO:0070096; P:mitochondrial outer membrane translocase complex assembly; ISS:FlyBase.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; ISS:FlyBase.
DR CDD; cd03212; GST_C_Metaxin1_3; 1.
DR CDD; cd03078; GST_N_Metaxin1_like; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF41; METAXIN-1 HOMOLOG; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..327
FT /note="Metaxin-1 homolog"
FT /id="PRO_0000220994"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 327 AA; 37252 MW; 83F68B28AFE6B0A2 CRC64;
MEMQLGAMLY VYKGEYGLPS IDFECLRALC LLRFTRCPMD VQTSSNPLRS GAGKLPYLQI
GNQKFAGYRQ IKRVLDLEGY PIDAHLSTKQ KHLSTAYANW VFTNLHAYYH YFLFGEPHNF
DTTTRGLYAK RTPFPFNFYY PSSYQREACD VVQVMAGFDV NDKLDKHEGD YLVVNAKKVV
NLLSRKLGRK VWFFGDTYSE FDAIVYSYLA IIFKIALPNN PLQNHIKGCQ NLVNFINRIT
KDIFRIEGYS SVKLTKTPSG TEASLTASER KFLDSELNTK IVAGVGAVLA MGAFAAWRGI
YNQLTTRSST DYDGIDYEDD EMEEGLD
//
