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Database: UniProt
Entry: MT_PODSI
LinkDB: MT_PODSI
Original site: MT_PODSI 
ID   MT_PODSI                Reviewed;          63 AA.
AC   Q708T3;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-OCT-2013, entry version 38.
DE   RecName: Full=Metallothionein;
DE            Short=MT;
OS   Podarcis sicula (Italian wall lizard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC   Lacertibaenia; Lacertidae; Podarcis.
OX   NCBI_TaxID=65484;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=14579413; DOI=10.1002/mrd.10365;
RA   Riggio M., Trinchella F., Filosa S., Parisi E., Scudiero R.;
RT   "Accumulation of zinc, copper and metallothionein mRNA in lizard ovary
RT   proceeds without a concomitant increase in metallothionein content.";
RL   Mol. Reprod. Dev. 66:374-382(2003).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine
CC       residues that bind various heavy metals (By similarity).
CC   -!- DOMAIN: Class I metallothioneins contain 2 metal-binding domains:
CC       four divalent ions are chelated within cluster A of the alpha
CC       domain and are coordinated via cysteinyl thiolate bridges to 11
CC       cysteine ligands. Cluster B, the corresponding region within the
CC       beta domain, can ligate three divalent ions to 9 cysteines.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1
CC       family.
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DR   EMBL; AJ609541; CAE81349.1; -; mRNA.
DR   ProteinModelPortal; Q708T3; -.
DR   SMR; Q708T3; 32-63.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.10.10; -; 1.
DR   InterPro; IPR017854; Metalthion_dom.
DR   InterPro; IPR023587; Metalthion_dom_vert.
DR   InterPro; IPR003019; Metalthion_sfam_euk.
DR   InterPro; IPR000006; Metalthion_vert.
DR   InterPro; IPR018064; Metalthion_vert_metal_BS.
DR   PANTHER; PTHR23299; PTHR23299; 1.
DR   Pfam; PF00131; Metallothio; 1.
DR   PRINTS; PR00860; MTVERTEBRATE.
DR   SUPFAM; SSF57868; SSF57868; 1.
DR   PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Metal-thiolate cluster.
FT   CHAIN         1     63       Metallothionein.
FT                                /FTId=PRO_0000197267.
FT   REGION        1     30       Beta.
FT   REGION       31     63       Alpha.
FT   METAL         6      6       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL         8      8       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        14     14       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        16     16       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        20     20       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        22     22       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        25     25       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        27     27       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        30     30       Divalent metal cation; cluster B (By
FT                                similarity).
FT   METAL        34     34       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        35     35       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        37     37       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        38     38       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        42     42       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        45     45       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        49     49       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        51     51       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        59     59       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        61     61       Divalent metal cation; cluster A (By
FT                                similarity).
FT   METAL        62     62       Divalent metal cation; cluster A (By
FT                                similarity).
SQ   SEQUENCE   63 AA;  6356 MW;  4A892600DE378C51 CRC64;
     MDPQDCACAT GASCTCAGSC KCKNCKCTSC KKSCCSCCPA GCAKCAKSCV CKEPLSDKCS
     CCT
//
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