ID MUCA_SALTM Reviewed; 146 AA.
AC P0A275; P07376; P14302;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 24-JAN-2024, entry version 81.
DE RecName: Full=Protein MucA;
DE EC=3.4.21.-;
DE Contains:
DE RecName: Full=Protein MucA';
GN Name=mucA;
OS Salmonella typhimurium.
OG Plasmid IncN R46.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hall R.M., Vockler C.;
RL Submitted (SEP-1989) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in UV protection and mutation. {ECO:0000250}.
CC -!- MISCELLANEOUS: The mucAB operon is the plasmid-borne analog of the
CC E.coli umuDC operon.
CC -!- SIMILARITY: Belongs to the peptidase S24 family. {ECO:0000305}.
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DR EMBL; X16596; CAA34606.1; -; Genomic_DNA.
DR PIR; S06775; S06775.
DR RefSeq; NP_511216.1; NC_003292.1.
DR RefSeq; WP_000861760.1; NZ_RQPP01000027.1.
DR AlphaFoldDB; P0A275; -.
DR SMR; P0A275; -.
DR MEROPS; S24.003; -.
DR GeneID; 83649171; -.
DR PRO; PR:P0A275; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd06529; S24_LexA-like; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR InterPro; IPR039418; LexA-like.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR006197; Peptidase_S24_LexA.
DR InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR PANTHER; PTHR33516; LEXA REPRESSOR; 1.
DR PANTHER; PTHR33516:SF13; PROPHAGE REPRESSOR COHE-RELATED; 1.
DR Pfam; PF00717; Peptidase_S24; 1.
DR PRINTS; PR00726; LEXASERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage; DNA damage; DNA repair; Hydrolase; Plasmid;
KW Protease; Serine protease; SOS mutagenesis; SOS response.
FT CHAIN 1..146
FT /note="Protein MucA"
FT /id="PRO_0000041986"
FT CHAIN 27..146
FT /note="Protein MucA'"
FT /id="PRO_0000027301"
FT ACT_SITE 62
FT /note="For autocatalytic cleavage activity"
FT /evidence="ECO:0000250"
FT ACT_SITE 99
FT /note="For autocatalytic cleavage activity"
FT /evidence="ECO:0000250"
FT SITE 26..27
FT /note="Cleavage; by autolysis"
SQ SEQUENCE 146 AA; 16527 MW; 7605A681F8345E76 CRC64;
MKVDIFESSG ASRVHSIPFY LQRISAGFPS PAQGYEKQEL NLHEYCVRHP SATYFLRVSG
SSMEDGRIHD GDVLVVDRSL TASHGSIVVA CIHNEFTVKR LLLRPRPCLM PMNKDFPVYY
IDPDNESVEI WGVVTHSLIE HPVCLR
//
