ID   MUTL_HAEIG              Reviewed;         629 AA.
AC   A5UFN4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=CGSHiGG_02850;
OS   Haemophilus influenzae (strain PittGG).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374931;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittGG;
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA   Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT   nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000672; ABQ99589.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5UFN4; -.
DR   SMR; A5UFN4; -.
DR   KEGG; hiq:CGSHiGG_02850; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   Proteomes; UP000001990; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03482; MutL_Trans_MutL; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..629
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010022"
SQ   SEQUENCE   629 AA;  71693 MW;  8D54DECEF3DC7255 CRC64;
     MPIKILSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAN KIQIDIENGG ANLIRIRDNG
     CGIPKEELSL ALARHATSKI ADLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTEEQTEA
     WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL
     TKFNTAFTLT HNGKIIRQYR PAEELNQQLK RVAAICGDDF VKNALRIDWK HDDLHLSGWV
     AKPNFSRTQN DLSYCYINGR MVRDKVISHA IRQAYAQYLP TDAYPAFVLF IDLNPHDVDV
     NVHPTKHEVR FHQQRLIHDF IYEGISYALN NQEQLNWHTD QSAVENHEEN TVREPQPNYS
     IRPNRAAAGQ NSFAPQYHEK PQQNQPHFSN TPVFPNHVST GYRDYRSDAP SKIEQRLYAE
     LLRTLPPTAQ KDISDTAQQN ISDTAKIIST EIIECSSHLR ALSLIENRAL LLQQNQDFFL
     LSLEKLQRLQ WQLALKQIQI EQQPLLIPIV FRLTEAQFQA WQQYSDNFKK IGFEFIENQA
     QLRLTLNKVP SALRTQNLQK CVMAMLTRDE NSSSFLTALC AQLECKTFNT LADALNLLSE
     TERLLTQTNR TAFTQLLKPV NWQPLLDEI
//