ID MUTL_STRP8 Reviewed; 660 AA.
AC Q8NZ25;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=spyM18_2179;
OS Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=186103;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGAS8232;
RX PubMed=11917108; DOI=10.1073/pnas.062526099;
RA Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA Veasy L.G., Musser J.M.;
RT "Genome sequence and comparative microarray analysis of serotype M18 group
RT A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; AE009949; AAL98623.1; -; Genomic_DNA.
DR RefSeq; WP_011018317.1; NC_003485.1.
DR AlphaFoldDB; Q8NZ25; -.
DR SMR; Q8NZ25; -.
DR KEGG; spm:spyM18_2179; -.
DR HOGENOM; CLU_004131_4_1_9; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..660
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000177982"
SQ SEQUENCE 660 AA; 74418 MW; F6C42D5B0037D89D CRC64;
MTNIIELPEV LANQIAAGEV VERPASVVKE LVENAIDAKS SQITVEIEES GLKMIQVTDN
GEGMSHEDLP LSLRRHATSK IKSQSDLFRI RTLGFRGEAL PSVASISKIT IKTATKEVTH
GSLLIATGGE IETLEAISTP TGTKIKVENL FYNTPARLKY MKSLQAELAH IVDVVNRLSL
AHPEVAFTLI SDGRQLTQTS GTGDLRQAIA GIYGLNTTKK MLVISNADLD FEVSGYVSLP
ELTRANRNYM TILVNGRYIK NFLLNRAILD GYGSKLMVGR FPIVVIDIQI DPYLADVNVH
PTKQEVRISK ERELMALIST AISESLKEQD LIPDALENLA KSSTRHFSKP EQTQLPLQSR
GLYYDPQKND FFVKESAVSE KIPETDFYFG AVDNSVKVEK AELLPHSEEV IGPSSVKHAS
RPQNTFTETD HPNLDLKNRQ KLSQMLTRLE NEEQSVFPEL DYFGQMHGTY LFAQGKDGLF
IIDQHAAQER VKYEYYRDKI GEVDSSLQQL LVPYLFEFSG SDFINLQEKM ALLNEVGIFL
EVYGHNTFIL REHPIWMKEE EIASGVYEMC DMLLLTNEVS IKTYRAELAI MMSCKRSIKA
NHSLDDYSAR NLLLQLAQCQ NPYNCPHGRP VLINFSKADM EKMFRRIQEN HTSLRELGKY
//
