ID MUTS_ACTPJ Reviewed; 864 AA.
AC B0BRS8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=APJL_1635;
OS Actinobacillus pleuropneumoniae serotype 3 (strain JL03).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=434271;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JL03;
RX PubMed=18197260; DOI=10.1371/journal.pone.0001450;
RA Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W.,
RA Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T.,
RA Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S.,
RA Zhao G.-P., Chen H.;
RT "Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of
RT serotype 3 prevalent in China.";
RL PLoS ONE 3:E1450-E1450(2008).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000687; ABY70187.1; -; Genomic_DNA.
DR RefSeq; WP_012263308.1; NC_010278.1.
DR AlphaFoldDB; B0BRS8; -.
DR SMR; B0BRS8; -.
DR KEGG; apj:APJL_1635; -.
DR HOGENOM; CLU_002472_4_0_6; -.
DR Proteomes; UP000008547; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..864
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335103"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 864 AA; 95612 MW; 7300DFDE62836BCC CRC64;
MTQDLSKHTP MMAQYLQLKA QNPDILLFYR MGDFYELFYD DAKKAAALLD ISLTKRGASA
GEPIPMAGVP YHAVEGYLAK LVSLGESVAI CEQIGDPATS KGPVERKVVR IVTPGTVSDE
ALLPERQDNL VAAIYEEKGV FAIATLDMTS GRFLITELPN KEALAAELQR LQLAEILYAE
DFSAAEILNN YKGLRRRPVW EFELVTAINL LNRQFGTQSL AGFGVEKAVV ALCAAGCVLH
YAQETQRTAL PHINSIHLAQ NSDTVLLDAA TRRNLELTQN LAGGTENTLA AVLDKCVTPM
GSRLLKRWIH QPIRDLEKLK KRQDIIDTLQ KEQRIEPLQP LLQNVGDMER ILARVALRSA
RPRDLTRLRT ALAQLPDIAK NAKNLTASLD ALVAQIGDFS ELHALLERAI IETPPQLIRD
GGVIAEGYNA ELDEWRELSA GATQYLENLE IREREATGID TLKIGFNAVH GYYIQISQGQ
AHKAPMHYVR RQTLKNAERY IIPELKTYED KVLKAKGASL ALEKQLYDEL FDLLMPRLGE
MQLAAMALSE LDVLTNLAER AESLNYVRPT FSLQRGVNIK GGRHPVVEQV LKDPFIANPV
FLNAQRHLLV VTGPNMGGKS TYMRQIALIS LMAYIGSFVP ADSAEIGALD RIFTRIGASD
DLASGRSTFM VEMTEMANIL HQATENSLVL IDEIGRGTST YDGLSLAWAC AEWLAKKTQS
LTLFATHYFE LTSLPSQLKG VANVHLDARE HQDSIVFMHS VQEGAASKSY GLAVAALAGV
PKQVIQLAKQ RLAHLEEISL QTKEAHDNPQ GDLLFAADLQ ETPQIQPLVA QQSELEKALM
SIDPDELTPR QALEALYRLK KLMA
//
