ID MUTS_ANADF Reviewed; 882 AA.
AC A7HC64;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Anae109_2107;
OS Anaeromyxobacter sp. (strain Fw109-5).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Anaeromyxobacteraceae; Anaeromyxobacter.
OX NCBI_TaxID=404589;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fw109-5;
RX PubMed=25614562; DOI=10.1128/genomea.01449-14;
RA Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Glavina Del Rio T.,
RA Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.C.,
RA Detter J.C., Han C.S., Schmutz J., Larimer F.W., Land M.L., Hauser L.J.,
RA Kyrpides N., Lykidis A., Richardson P., Belieav A., Sanford R.A.,
RA Loeffler F.E., Fields M.W.;
RT "Complete genome sequence of Anaeromyxobacter sp. Fw109-5, an anaerobic,
RT metal-reducing bacterium isolated from a contaminated subsurface
RT environment.";
RL Genome Announc. 3:0-0(2015).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000769; ABS26310.1; -; Genomic_DNA.
DR RefSeq; WP_012096890.1; NC_009675.1.
DR AlphaFoldDB; A7HC64; -.
DR SMR; A7HC64; -.
DR STRING; 404589.Anae109_2107; -.
DR KEGG; afw:Anae109_2107; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_7; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000006382; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..882
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335112"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 882 AA; 95275 MW; AC3637F598636A38 CRC64;
MPEIAQPTPM MRQYLETKAR YPDALLFFRL GDFYELFFED ALTASEALQI TLTARAKGDD
KVPMCGVPHH AARGYVARLL EKGFKVAICD QVEEPGKSAI VKREVTRVVT PGMVFDDQVL
DPREASYLGV VALAEGRAGL ALLDASTGQL QCGEVPDDAR AVDELRRAGV RELVLPLGAD
AARAERIERA VGVPAARRPA ADYERADDRL RRHLGVASLD GFGVGGEPLG LAAAAAALAY
LADTQRATPR HVDRVSRLRT EDVLLLDEAT RTNLELERTL NGGRKKGSLL ALLDRSVTAP
GGRRLAEWLR YPLTELAPIH ARLDAVEELA GASVAREDLA AALRPVADAE RLLSRLVLGQ
GNARDLRALA GALLALPALA ELLGGRAAAL LRDAGEGTRG LEELAAHLDR AVAEEPPATL
REGGIIRRGF SPELDEIVAV AEDGKGFIAR LEAREKERTG IGSLKVRFNK VFGYYLEVTK
ANLHAVPSDY ERRQTTVGGE RFVTPELKRF EETVLTAEER RIAVEGRLFE ELRQRVAEAA
PRIRTAADAV ATADALLALA RVAAERGYCR PEVDGSEVLE IVDGRHPVVE AVLPEGPAGF
VPNDVLVASR GALECERLGA LHVITGPNMA GKSTVMRQAA LVTLLAQMGA FVPARKARVG
IVDRIFTRVG ASDDLARGRS TFMVEMTETA AILHNATRRS LVVLDEIGRG TSTFDGVSIA
WAVAEHLHDQ VGCRTLFATH YHELQDLARE RPAVRNLTVA VREVGDRVVF LRKLVQGGAS
RSYGIEVAKL AGLPAEVLAR AREILKNLEA LEVDEGGHAA LARGRKTRRA DPQSQLGLFA
PAPAPADPAL EEIASALRAT EIDALRPLDA LNLLAAWRAK LR
//
