ID MUTS_AZOC5 Reviewed; 931 AA.
AC A8I275;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=AZC_4714;
OS Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG
OS 6465 / NBRC 14845 / NCIMB 13405 / ORS 571).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Xanthobacteraceae; Azorhizobium.
OX NCBI_TaxID=438753;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB
RC 13405 / ORS 571;
RA Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T.,
RA Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B.,
RA Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.;
RT "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium
RT caulinodans ORS571.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AP009384; BAF90712.1; -; Genomic_DNA.
DR AlphaFoldDB; A8I275; -.
DR SMR; A8I275; -.
DR STRING; 438753.AZC_4714; -.
DR KEGG; azc:AZC_4714; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR Proteomes; UP000000270; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..931
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335115"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 674..681
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 931 AA; 100416 MW; 19091FDBF13D0E6C CRC64;
MMDDTAMPAR AEADAAEDEL AAPAGIDRTA KADKDANRVS PMMAQYVEIK AANPGSLLFY
RMGDFYELFF EDAEIASQAL GIVLTKRGKH LGEDIPMCGV PLTRSEEYLH KLIALGHRVA
VCDQLEDPAE AKKRGSKSVV KRDVIRLVTP GTITEDSLLD AKRENVLLAV ARTRASGEGA
YDYALAFTDV STGSFRVVAS DGDMLAADLA RIDPAEILVS DAVYDDEELR DFWRGLSTPV
TPLPKQSFDG PQAEKRLAAF FGVATADSFG SFARAELIAA AAVVAYIERT QLGARPALAP
PQREADGGSM LIDAGTRVNL ELIRTTSGER RGSLLAAIDR TVTAAGARLL ARRLAEPLTD
IAAIRARHDA VGFLVEETEL REALRKRLAA APDLARALSR ISLGRGSPRD LGAIAAGLKE
GLAISSAFGP ETPRDIARCA RLLAAVEPWL AEELTAALAD ELPLNRRDGG FVRQGYDLDL
DSTRALRDES RRVVAALERR YVDETGIKSL KIRHNAVLGY FVEVTAQNAD RLREAPFNAT
FVHRQTMAGA VRFTSVELGD LESRIASAGE RALALEQTIF DRLAAAVIEA SRPIREAAEA
LAELDVLTAL ARLAVDERYV RPEMTEGVDF AISGGRHPVV EQALARGGGP FVANDCDLSP
PETAQDARIW LVTGPNMAGK STFLRQNALI AVLAQAGAFV PARAARLGVV DRLFSRVGAA
DDLARGRSTF MVEMVETAAI LNQATRRSLV ILDEIGRGTS TFDGMSIAWA SLEHLHEVNR
CRALFATHFH ELTALTQRCQ RLANATVKVT EWQGDVVFLH EVIPGAADRS YGIQVAKLAG
LPKMVIARAK AVLTELEAAE RVSPAQRLLD ELPLFAAAAR PAPTLAAPTG PHPAEPVLEE
LDRLDPDALT PRAALDALYR LKAMLRDAAD D
//
