ID MUTS_BURMA Reviewed; 891 AA.
AC Q62J26;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BMA1671;
OS Burkholderia mallei (strain ATCC 23344).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=243160;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23344;
RX PubMed=15377793; DOI=10.1073/pnas.0403306101;
RA Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E.,
RA Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C.,
RA Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J., Durkin A.S.,
RA Gwinn M.L., Haft D.H., Khouri H.M., Kolonay J.F., Madupu R., Mohammoud Y.,
RA Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C.,
RA Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M.;
RT "Structural flexibility in the Burkholderia mallei genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000010; AAU47784.1; -; Genomic_DNA.
DR RefSeq; YP_103293.1; NC_006348.1.
DR AlphaFoldDB; Q62J26; -.
DR SMR; Q62J26; -.
DR KEGG; bma:BMA1671; -.
DR PATRIC; fig|243160.12.peg.1707; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_4; -.
DR Proteomes; UP000006693; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..891
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000224355"
FT BINDING 634..641
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 891 AA; 96327 MW; 9176012F727E243A CRC64;
MATQIDASSE AAAATAAAQH TPMMQQYLRI KSEHPDTLVF YRMGDFYELF FEDAEKAARL
LDLTLTQRGA SAGTPIKMAG VPHHAVEQYL AKLVKFGESA AICEQIGDPA TSKGPVERKV
VRVVTPGTLT DAALLSDKSD VFLLALCVGH NKRGVASNIG LAWLNLASGA LRLAELAPDQ
LGAALERIRP AEILAADGTI ESVPAGMGAI TRVPAWHFDI ASGTQRLCDQ LEVASLDGFG
AQALTSANGA AGALLIYAAA TQGQQLRHVR SLKVENESEY IGLDPSTRRN LELTETLRGT
ESPTLYSLLD TCCTAMGSRL LRHWLHHPPR ASVAAQARHQ AIGALLDAPP NAGLDSLRSA
LRQIADVERI TGRLALLSAR PRDLSSLRDT FAALPALRER VAEIASNAAA LGRLEAALEP
PPGCLDLLTR AIAAEPAAMV RDGGVIARGY DAELDELRDI SENCGQFLID LETRERARTG
ISNLRVEYNK VHGFYIEVTR GQTDKVPDDY RRRQTLKNAE RYITPELKTF EDKALSAQER
ALARERALYD GVLQALLPHI EGCQRVASGL AELDLLAAFA ERARTLDWVA PEFTDEIGIE
IDQGRHPVVE AQVEQFIAND CALNPERKLL LITGPNMGGK STFMRQTALI ALMAYVGSYV
PAKAARFGPI DRIFTRIGAA DDLAGGRSTF MVEMTEAAAI LNDATPHSLV LMDEIGRGTS
TFDGLALAWA IARHLLSHNR CYTLFATHYF ELTQLPAEFP QAANVHLSAV EHGHGIVFLH
AVEEGPANQS YGLQVAQLAG VPAPVIRAAR KHLAHLEQQS AAQATPQLDL FAAPPVVDEP
ECNEPPAAAT PHPALERLLE LDPDDLKPRD ALDLLYELHT LARSGPADAQ R
//
