ID MUTS_FRATH Reviewed; 844 AA.
AC Q2A5B5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=FTL_0294;
OS Francisella tularensis subsp. holarctica (strain LVS).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=376619;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVS;
RA Chain P., Larimer F., Land M., Stilwagen S., Larsson P., Bearden S.,
RA Chu M., Oyston P., Forsman M., Andersson S., Lindler L., Titball R.,
RA Garcia E.;
RT "Complete genome sequence of Francisella tularensis LVS (Live Vaccine
RT Strain).";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AM233362; CAJ78735.1; -; Genomic_DNA.
DR RefSeq; WP_003014457.1; NZ_CP009694.1.
DR AlphaFoldDB; Q2A5B5; -.
DR SMR; Q2A5B5; -.
DR KEGG; ftl:FTL_0294; -.
DR Proteomes; UP000001944; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..844
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335157"
FT BINDING 610..617
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 844 AA; 95813 MW; A87B7D80BA35143C CRC64;
MQDISNHTPM IQQYLKIKSQ YQDILLFYRM GDFYELFFDD AKKAAELLDI TLTARGKSNG
ESIPMAGVPY HAAEAYIAKI VKKGLSIAIC EQTGDPNTSK GPVERQVTRI ITPATVSEEA
FLDNNQDSIL VSIFEKNNKY YLAYTSYTQG KIYLVKTLTS LNELKNTVLK LSPQEIITNS
RELAQQNPFK KPIKALEEWY YSNFEAKKYI NDSLDTNIAN NILNLYKNDQ LTTIGSILSY
LTNILKDTPR HITDISYEQE QDTLNIDINS RINLELDNNS KSSLLSIIGK CKTSLGSRLL
KRYFSNPTRN LNILATRHSI INSLGENQHF LKIQDVLSYI SDIERIISRV ALGTVKPKDL
VALRYSLEQL PILKKLLSEK NTPEITNINN RIHQLDELVT LLDKAIIENP PTTIRDGGVI
KEGFDKELDE LKSIKDNSYD FLIKFEELQK QKIGISTLKV GYNRVHGYYI ELSKQHADKI
PTEYVRRQTL KASERYITEE LKNFEDKVLS SKEKALAREK LIYDTLLKKV IEYYKQIQET
AASIAEIDVL ANFAERAIKL KLSQPKFNNL AKLELKEVRH LAIEHNIDEP FIPNDTLLSK
DTNTLQIITG PNMGGKSTYM RQVAQLIFLA YIGSFVPASY ADICDIDTIY TRIGASDDIS
SGRSTFMVEM TETAYILNNA SAKSLVIMDE IGRGTSTFDG LALAKACAEK FAQMGAFTLF
ATHYFELTEL AKQYPNVCNI HFEAKEYKDN IYFMHKAVTG AAKKSYGIQV AKLAGISQDV
LESAKQNLYN LEKKQQLTES TQVQAQFQLE PTTQNPLQQK LDAIDINTIT PLEALNILFE
LKKR
//
