ID MUTS_GEOSW Reviewed; 860 AA.
AC C5D9H5;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=GWCH70_1202;
OS Geobacillus sp. (strain WCH70).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=471223;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WCH70;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Brumm P., Mead D.A., Richardson P.;
RT "Complete sequence of chromosome of Geopacillus sp. WCH70.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP001638; ACS24061.1; -; Genomic_DNA.
DR AlphaFoldDB; C5D9H5; -.
DR SMR; C5D9H5; -.
DR STRING; 471223.GWCH70_1202; -.
DR KEGG; gwc:GWCH70_1202; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_1_3_9; -.
DR OrthoDB; 9802448at2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..860
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000202738"
FT BINDING 606..613
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 860 AA; 98631 MW; 0134290F4BE9A1BA CRC64;
MATYTPMIQQ YLDIKAQYPD AFLFFRLGDF YEMFFDDAIK AAQELEITLT SRDGGGEERV
PMCGVPYHSA QGYIEQLISK GYKVAICEQV EDPKTAKGVV RREVVQLITP GTVMEGKGLL
DKENNYLATV TMFDDGTYGF AYTDLSTGEN RITLLASLDD VMNELYAIGT KEIVISSQFP
EQYQQLLKER YDVTISYEDE TVIPEGFTSI VEALQQDKLK ITFGRLLHYI IRTQKRRLDH
MQSVQVYQVD HYMKIDLYSK RNLELTETIR SKGRKGSLLW LLDETVTAMG GRLLKQWLDR
PLLDRKQIER RLHMVETLIH HYFERQELRE RLREVYDVER LAGRVAYGNV NARDLIQLKK
SLQQIPALKD IVEKLPDHEA KQLANKLDPC SELVDLLERS IQENPPLSVK EGNIIKDGYN
ETLDRYRDAS RNGKAWIAQL ESKERELTGI KSLKIGYNRV FGYYIEVTKP NLHLLPKGRY
ERKQTLANAE RFITQELKEK EALILEAEEK SIELEYELFV DIRERVKQYI PRLQSLAKTI
SELDVLQSFA TVSEERHYVK PQFSDNRELI IQAGRHPVVE KVLGAQTYVP NDCYMNKERE
LLLITGPNMS GKSTYMRQIA LTVIMAQIGC FVPAEKAVLP IFDQVFTRIG AADDLVSGQS
TFMVEMLEAR NAIVHATQNS LILFDEIGRG TSTYDGMALA QAIIEYIHDH IGAKTLFSTH
YHELTDLEQS LAKLKNVHVR AVEENGKVVF LHKIEEGPAD QSYGIHVAEL AELPASLIQR
AKEILAELEQ QEQRKEQPSG KNEAVFEQLS MFAEEQPSKE ESHLSKKEKK ALEALKSVNL
LETTPLEALN KLYEIQKLLK
//
