ID MUTS_PROMS Reviewed; 913 AA.
AC A2BTM6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=A9601_18541;
OS Prochlorococcus marinus (strain AS9601).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=146891;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AS9601;
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000551; ABM71137.1; -; Genomic_DNA.
DR RefSeq; WP_011819255.1; NC_008816.1.
DR AlphaFoldDB; A2BTM6; -.
DR SMR; A2BTM6; -.
DR STRING; 146891.A9601_18541; -.
DR KEGG; pmb:A9601_18541; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_1_3_3; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000002590; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..913
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335197"
FT BINDING 720..727
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 913 AA; 103303 MW; BC01F362EFC18EFD CRC64;
MQEDTIIQKN LFAIGNDINE QKKITKIPEN LSLEDLKKES QKRPRQRKNS TNLINKFKTD
LISNNKNVCI NEESYSYKTV SKLKLTPVMK HYVTLKEENK DRLLLYRLGD FFECFFEDAV
LISNLLEITL TSKDAGKEIG KIPMAGVPHH AMERYCADLI KKNYSVVICD QLEKSSGNYG
TPIKRGITRI ITPGTVIEEG MLIAKKNNWI SAIYLSEENS DESYEWGISK ADVSTGELIT
LEGQSLSKLF DEIIKLDSSE IIVGSNTARD LLIKGNSQIT YTVSQETNFG INEANYLIKN
YFQIANLEGI GLKNLNNATR SLGGLLNYLE KINPSNLDKD SSLKISLDFP QIQYGHNKLI
IDYQTQKNLE IKNTQRENNY VGSLLWSIDR TYTCMGARCL RRWIDSPLLN VNEIYKRQNI
ITNFLESKKL RIDTQNLLRA MGDLERLAGR ACAGHASPRD LIAIAEGLKK LPRLKSIIEL
FKYDLPDWTD QLKNIDEGLL ELADTISFKL VENPPLNISE GGMIHDGVDN ILDGLRNLMD
DYSEWLNKEE SKERKISKIS NLKIQFHKNF GYYISINKSK VNLAPQHWIK RQTLTNEERY
ITSEIKNKEN KIFQIKSRAS SKEYEIFCEL RNIVAEKTKQ IRSIAKSIAS LDALLGLSIT
SVENNFIKPS LIPINDSMTK NSTKIIAGRN PIVEQLLSDK KFVANDISFE DNQKLIILTG
PNASGKSCFI RQLGLIQILT QIGSFVPANN AEIKIADRIF TRIGAVDDQS SGQSTFMVEM
SETASILNQA TSSSLVLLDE IGRGTSTFDG LSIAWSVSEY LAKKIQCNTI FATHYHELNY
LKNTNKNIQN FQVLVEQNND QLIFSHRIVK GGSNKSYGIE AAKLAGVPKE VIEKAKSVLN
SLEENNKLNY DIK
//
