ID MUTS_PSYCK Reviewed; 1040 AA.
AC Q1QE46;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Pcryo_0273;
OS Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378
OS / K5).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Psychrobacter.
OX NCBI_TaxID=335284;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D.,
RA Han C., Tapia R., Sims D.R., Gilna P., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Richardson P.;
RT "Complete sequence of chromosome of Psychrobacter cryohalolentis K5.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000323; ABE74057.1; -; Genomic_DNA.
DR RefSeq; WP_011512645.1; NC_007969.1.
DR AlphaFoldDB; Q1QE46; -.
DR SMR; Q1QE46; -.
DR STRING; 335284.Pcryo_0273; -.
DR KEGG; pcr:Pcryo_0273; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_1_6; -.
DR Proteomes; UP000002425; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..1040
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335206"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 759..766
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 1040 AA; 114553 MW; 9BF2AE74F5746180 CRC64;
MPVKPSAQNN SPSKPTSKSV PVDSDSLVIG DAIYHLADHT PMMVQYLNMK VNYPQALLLY
RMGDFYELFF EDAKRAAQIL DITLTRRGTD KAGNTIAMAG VPFHAADSYM ARLIAAGQTV
VVCEQIDESA TGTDNANNPS NAPTMGDKQK KDKSKSTAGT IMRREVVKTL TAGTITDDAL
IAPNHTPTVV AIDIETPKSN SKQPVQAAVS QMDLAAGTLT TQTISANQDD IESLQTQMLT
VLARFAPSEC IISEALSDSN GDISEEWLLW LRQHLNCPII EVAANDFHRE HASATLCQQF
EVQRLDGLGI SGAPLAQSSC AALIHYARQT QQRHVPQLNQ LIVEYNDDYL IIDANSQQNL
ELFTPVSSNG TSLISVLNHC QTPMGRRLLV QQMKRPLRQH SRINLRLDAI TSLLDTDKQS
EQCSGNISLV TSLRETLNAI GDIERISSRI GLMSAKPRDL RKLADGIASS AQLTTLLTNA
GISHEQAGLL PMLMQQLPAQ LPAVQSVAEL IERAIIVEPP AHIRDGGMLA AGYDAEFDRL
THLHDNIQVT LDEMVERARQ ESQLPSLKVG FNKVSGFYFE LPKMQAKNAP AHFIRRQTLK
SSERFITNEL KTVETEYLSA QSLALTREKQ LYNELLIRLG SHLAELQQLS AAIAQIDVLN
NWAQLAITYN WQRPVMSNES KKSSILDNSL ENSHSENGLN NNSQTSINIK EGRHVVVEAV
LNPIHTHQNN PAKHSSHFVA NDCVLGSYEN PERLLMITGP NMGGKSTYMR QTALIVLLAH
CGSFVPAARA HIGDIDRIFT RIGSADDLAG GKSTFMVEMI ETANILNQAT NKSLVLMDEV
GRGTATTDGL AIAHACVNRL VEIGCLTLFA THYFELTKLA QNPKESSGSN DKFIRNVHVA
ASEIDGQLLL LHQIKDGAAS SSFGLHVAKM AGIPIQVLND AKRYLVDNLS IDNLKPDNES
IDDDKNELAK SVKDKRQQTY DSNIEKSNIR NLDKKQKNID IPQQNQLFSL QDELQAIDPD
SLTPKQAHDL LYHLKEIISY
//
