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Database: UniProt
Entry: MVP_METJA
LinkDB: MVP_METJA
Original site: MVP_METJA 
ID   MVP_METJA               Reviewed;         209 AA.
AC   Q57603;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   07-JUN-2017, entry version 99.
DE   RecName: Full=Hyperpolarization-activated voltage-gated potassium channel;
DE   AltName: Full=MVP;
GN   Name=mvp; OrderedLocusNames=MJ0139;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 /
OS   JCM 10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RX   PubMed=12640457; DOI=10.1038/nn1028;
RA   Sesti F., Rajan S., Gonzalez-Colaso R., Nikolaeva N.,
RA   Goldstein S.A.N.;
RT   "Hyperpolarization moves S4 sensors inward to open MVP, a
RT   methanococcal voltage-gated potassium channel.";
RL   Nat. Neurosci. 6:353-361(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D.,
RA   Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D.,
RA   Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I.,
RA   Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A.,
RA   Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D.,
RA   Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C.,
RA   Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M.,
RA   Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=12860407; DOI=10.1016/S0014-5793(03)00706-3;
RA   Hellmer J., Zeilinger C.;
RT   "MjK1, a K+ channel from M. jannaschii, mediates K+ uptake and K+
RT   sensitivity in E. coli.";
RL   FEBS Lett. 547:165-169(2003).
CC   -!- FUNCTION: Voltage-gated potassium-selective channel opened by
CC       hyperpolarization. {ECO:0000269|PubMed:12860407}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC       characterized by a series of positively charged amino acids.
CC   -!- MISCELLANEOUS: Inhibited by barium.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000305}.
DR   EMBL; AY268105; AAP31055.1; -; mRNA.
DR   EMBL; L77117; AAB98122.1; -; Genomic_DNA.
DR   PIR; C64317; C64317.
DR   RefSeq; WP_010869632.1; NC_000909.1.
DR   ProteinModelPortal; Q57603; -.
DR   STRING; 243232.MJ_0139; -.
DR   TCDB; 1.A.1.6.1; the voltage-gated ion channel (vic) superfamily.
DR   PRIDE; Q57603; -.
DR   EnsemblBacteria; AAB98122; AAB98122; MJ_0139.
DR   GeneID; 1450980; -.
DR   KEGG; mja:MJ_0139; -.
DR   eggNOG; arCOG01964; Archaea.
DR   eggNOG; COG1226; LUCA.
DR   InParanoid; Q57603; -.
DR   KO; K10716; -.
DR   OMA; LSTYNPP; -.
DR   OrthoDB; POG093Z0DUI; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Ion channel; Ion transport;
KW   Membrane; Potassium; Potassium channel; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN         1    209       Hyperpolarization-activated voltage-gated
FT                                potassium channel.
FT                                /FTId=PRO_0000054098.
FT   TOPO_DOM      1     10       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     11     31       Helical; Name=Segment S1. {ECO:0000255}.
FT   TOPO_DOM     32     38       Extracellular. {ECO:0000255}.
FT   TRANSMEM     39     59       Helical; Name=Segment S2. {ECO:0000255}.
FT   TOPO_DOM     60     71       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     72     92       Helical; Name=Segment S3. {ECO:0000255}.
FT   TOPO_DOM     93     96       Extracellular. {ECO:0000255}.
FT   TRANSMEM     97    117       Helical; Voltage-sensor; Name=Segment S4.
FT                                {ECO:0000255}.
FT   TOPO_DOM    118    125       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    126    146       Helical; Name=Segment S5. {ECO:0000255}.
FT   TOPO_DOM    147    181       Extracellular. {ECO:0000255}.
FT   TRANSMEM    182    202       Helical; Name=Segment S6. {ECO:0000255}.
FT   TOPO_DOM    203    209       Cytoplasmic. {ECO:0000255}.
FT   MOTIF       170    175       Selectivity filter. {ECO:0000250}.
SQ   SEQUENCE   209 AA;  24183 MW;  FC91E7320F34D90F CRC64;
     MNLKDRRLKK IMEVLSLIFT FEIVASFILS TYNPPYQDLL IKLDYISIMF FTFEFIYNFY
     YVEDKAKFFK DIYNIVDAIV VIAFLLYSLQ VFYSKAFLGL RVINLLRILV LLRIIKLRKL
     EENQALINFL TLLTICFIAS CLIWIVESGV NPAINNFFDA FYFTTISITT VGYGDITPKT
     DAGKLIIIFS VLFFISGLIT SLQKALKGD
//
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