ID MYB1_PLAF7 Reviewed; 414 AA.
AC Q8IEF6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 24-JAN-2024, entry version 135.
DE RecName: Full=Myb1 protein {ECO:0000312|EMBL:CAD52303.2};
DE Short=PfMyb1 {ECO:0000303|PubMed:15500927, ECO:0000303|PubMed:15663925};
GN Name=myb1 {ECO:0000312|EMBL:CAD52303.2}; ORFNames=PF13_0088;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 16-45, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=15500927; DOI=10.1016/j.molbiopara.2004.07.011;
RA Boschet C., Gissot M., Briquet S., Hamid Z., Claudel-Renard C., Vaquero C.;
RT "Characterization of PfMyb1 transcription factor during erythrocytic
RT development of 3D7 and F12 Plasmodium falciparum clones.";
RL Mol. Biochem. Parasitol. 138:159-163(2004).
RN [5] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=15663925; DOI=10.1016/j.jmb.2004.11.045;
RA Gissot M., Briquet S., Refour P., Boschet C., Vaquero C.;
RT "PfMyb1, a Plasmodium falciparum transcription factor, is required for
RT intra-erythrocytic growth and controls key genes for cell cycle
RT regulation.";
RL J. Mol. Biol. 346:29-42(2005).
CC -!- FUNCTION: Transcriptional activator. Has a role in the parasite
CC erythrocytic cycle where it directly regulates key genes involved in
CC cell cycle regulation and progression. Binds directly to Myb regulatory
CC elements. {ECO:0000269|PubMed:15500927, ECO:0000269|PubMed:15663925}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15500927,
CC ECO:0000269|PubMed:15663925}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the erythrocytic development
CC of the infected host, low expression in rings and schizonts, high
CC levels in trophozoites. {ECO:0000269|PubMed:15500927}.
CC -!- DISRUPTION PHENOTYPE: dsRNA causes reduced expression, alters parasite
CC growth and trophozoite to schizont transition during the erythrocytic
CC cycle. {ECO:0000269|PubMed:15663925}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844509; CAD52303.2; -; Genomic_DNA.
DR RefSeq; XP_001349895.2; XM_001349859.2.
DR AlphaFoldDB; Q8IEF6; -.
DR SMR; Q8IEF6; -.
DR STRING; 36329.Q8IEF6; -.
DR PaxDb; 5833-PF13_0088; -.
DR EnsemblProtists; CAD52303; CAD52303; PF3D7_1315800.
DR GeneID; 814066; -.
DR KEGG; pfa:PF3D7_1315800; -.
DR VEuPathDB; PlasmoDB:PF3D7_1315800; -.
DR HOGENOM; CLU_708796_0_0_1; -.
DR InParanoid; Q8IEF6; -.
DR OMA; ECQKTWL; -.
DR OrthoDB; 1709448at2759; -.
DR PhylomeDB; Q8IEF6; -.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:GeneDB.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IDA:GeneDB.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46621; SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR46621:SF1; SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50090; MYB_LIKE; 3.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Merozoite; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..414
FT /note="Myb1 protein"
FT /id="PRO_0000388755"
FT DOMAIN 242..266
FT /note="Myb-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DOMAIN 268..320
FT /note="Myb-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT DOMAIN 328..381
FT /note="Myb-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
SQ SEQUENCE 414 AA; 49993 MW; 822E3A54A8415463 CRC64;
MFNNNNEYEC LCILEEKLVK HLDVIDKLIE NIYDNINNLN EYINKKYNEI KILASKKPTR
INWMKCDDKT HMSLFFDKKI GFIPSNEDAL KILDSQLMLS NYRKKYEYKK NSWTKKDIDK
LFETVDITLK KYACYYLIDQ NLSCDEKINK KKMIEQSEPK QIFSQIKLFF DKYNKENTHN
KGNEDNVNKN INDNISKNNI THTQNCYEPI EKEQDNSNNI FSYTKNDKNI EHNFLYFSET
FWNEVSEKLS NNQNAKECQK MWLYYGCFED DKQKKWTKDE VDKLLCLSKK YEQRNWKCIA
RELNTNRSPL SCFEQYIKIN KLYENKEKVK LERIAFNVLE DIQLQILVSI IGDKNWAEVK
KHMESLNSNT SRIKKRKTNL NFFEKEKQKK FLNDEISYKR RYLRLISATN NMEQ
//
