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Database: UniProt
Entry: N0B807_9RHIZ
LinkDB: N0B807_9RHIZ
Original site: N0B807_9RHIZ 
ID   N0B807_9RHIZ            Unreviewed;       506 AA.
AC   N0B807;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AGK56195.1};
GN   ORFNames=HYPDE_22543 {ECO:0000313|EMBL:AGK56195.1};
OS   Hyphomicrobium denitrificans 1NES1.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Hyphomicrobiaceae; Hyphomicrobium.
OX   NCBI_TaxID=670307 {ECO:0000313|EMBL:AGK56195.1, ECO:0000313|Proteomes:UP000005952};
RN   [1] {ECO:0000313|EMBL:AGK56195.1, ECO:0000313|Proteomes:UP000005952}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1NES1 {ECO:0000313|EMBL:AGK56195.1,
RC   ECO:0000313|Proteomes:UP000005952};
RX   PubMed=23833140;
RA   Venkatramanan R., Prakash O., Woyke T., Chain P., Goodwin L.A.,
RA   Watson D., Brooks S., Kostka J.E., Green S.J.;
RT   "Genome sequences for three denitrifying bacterial strains isolated
RT   from a uranium- and nitrate-contaminated subsurface environment.";
RL   Genome Announc. 1:e00449-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP005587; AGK56195.1; -; Genomic_DNA.
DR   RefSeq; WP_015596233.1; NC_021172.1.
DR   EnsemblBacteria; AGK56195; AGK56195; HYPDE_22543.
DR   KEGG; hdt:HYPDE_22543; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000005952; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005952};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005952}.
FT   DOMAIN      198    327       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      414    483       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     206    213       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   506 AA;  57056 MW;  3B9D6AC2F30C74D7 CRC64;
     MQAAKTAEAQ SVSGAQGTAV VETATDAIEG RGQKVRAMLR AQLGEEIYSS WFKSLEFEGF
     DGRVVKVSVP VKFVRNWIQE HYAERLLHCS RVEFATAERV EVVWRQPGAA VQRPAETRVE
     TPNAEKGPAA ALQTEAPARV SVLRPPVLPA QRTSAGGLEG SPLDPRYTFD SFVVGASNRM
     AHAGATQVAE TVLSDAPGYN PLYIHSAVGL GKSHLLQAIA WEVKRRAPTA QVLYLTAERF
     RYQFVEALRS SDPLAFKERF RNIHMLLIDD LEFLQGERTE QEFDHIINAL LDGGKQVVVA
     SARAPNQIER LNERMRSRLQ RGLVTELMPL DHELRLKVLE KRLGEKRAAD PSFTLSRDVV
     ELLALRLTEN GRELEGAVTR LYATWQYMRT PITLDIAETV IRDLVQNLEP RRIKIEDILR
     IISRHYGVSK GDLLSQRRHR SVVWPRQIGM YLAKHLTARS LPEIGRRFGG RDHTTVLHAI
     RKIEGEITKN PHLGDELEEL KRLLNH
//
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