ID N0BGG4_9EURY Unreviewed; 430 AA.
AC N0BGG4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Thymidylate synthase/dCMP hydroxymethylase domain-containing protein {ECO:0000259|Pfam:PF00303};
GN ORFNames=Asulf_02132 {ECO:0000313|EMBL:AGK62088.1};
OS Archaeoglobus sulfaticallidus PM70-1.
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=387631 {ECO:0000313|EMBL:AGK62088.1, ECO:0000313|Proteomes:UP000013307};
RN [1] {ECO:0000313|EMBL:AGK62088.1, ECO:0000313|Proteomes:UP000013307}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PM70-1 {ECO:0000313|EMBL:AGK62088.1};
RX PubMed=23833130;
RA Stokke R., Hocking W.P., Steinsbu B.O., Steen I.H.;
RT "Complete Genome Sequence of the Thermophilic and Facultatively
RT Chemolithoautotrophic Sulfate Reducer Archaeoglobus sulfaticallidus Strain
RT PM70-1T.";
RL Genome Announc. 1:e00406-13(2013).
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DR EMBL; CP005290; AGK62088.1; -; Genomic_DNA.
DR AlphaFoldDB; N0BGG4; -.
DR STRING; 387631.Asulf_02132; -.
DR KEGG; ast:Asulf_02132; -.
DR eggNOG; arCOG03214; Archaea.
DR HOGENOM; CLU_643417_0_0_2; -.
DR Proteomes; UP000013307; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 2.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 2.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000013307};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 78..180
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT DOMAIN 291..422
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 430 AA; 50532 MW; 38BD08535B362D5C CRC64;
MREVMIVSRT WEQAKEMLLK KIVSEGKKYL SRFGDTLRCE PSLVVVEKPD YFFDIEHDFS
GWTFCGESYL SRVEKVLDIC AEKIKSSPYT RRVSIPIWMP KDHHCRNPPA ITEISLLPVK
ELHATAYIRS LDAYNFFMHN ADFITFVLDY VAEKAGFDVG SAGFIASIPH IYLRDLKHID
LDSDYEEITG FHPLAVHLKE DYLSTAWHSA MEVVYHNGMT KRTEWGEIFE GQKESKFVQR
LFIEVKNPYE HQIHDKAPFT KKYAIDYAHD YMICAKFIDR PVNERILKEG ETYTYAERAR
YCERDDLIVD QLYTVIEKLK QDRYRRDCYV GISRIWDLKS DEPPCLRGYQ FVGDHDHLKG
IFYMRSNDIY GAMHANAYAF STLTQYVAEL TGFQRHKYYH FAVDAHIYGE FLKAVKEILE
PETPSFFDKT
//
