ID N1JA19_BLUG1 Unreviewed; 4357 AA.
AC N1JA19;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Nonribosomal peptide synthetase/nonribosomal siderophore peptide synthase {ECO:0000313|EMBL:CCU74732.1};
GN ORFNames=BGHDH14_bgh01135 {ECO:0000313|EMBL:CCU74732.1};
OS Blumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew)
OS (Oidium monilioides f. sp. hordei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Blumeria; Blumeria hordei.
OX NCBI_TaxID=546991 {ECO:0000313|EMBL:CCU74732.1, ECO:0000313|Proteomes:UP000015441};
RN [1] {ECO:0000313|EMBL:CCU74732.1, ECO:0000313|Proteomes:UP000015441}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DH14 {ECO:0000313|EMBL:CCU74732.1};
RX PubMed=21148392; DOI=10.1126/science.1194573;
RA Spanu P.D., Abbott J.C., Amselem J., Burgis T.A., Soanes D.M., Stueber K.,
RA Ver Loren van Themaat E., Brown J.K.M., Butcher S.A., Gurr S.J.,
RA Lebrun M.-H., Ridout C.J., Schulze-Lefert P., Talbot N.J., Ahmadinejad N.,
RA Ametz C., Barton G.R., Benjdia M., Bidzinski P., Bindschedler L.V.,
RA Both M., Brewer M.T., Cadle-Davidson L., Cadle-Davidson M.M., Collemare J.,
RA Cramer R., Frenkel O., Godfrey D., Harriman J., Hoede C., King B.C.,
RA Klages S., Kleemann J., Knoll D., Koti P.S., Kreplak J., Lopez-Ruiz F.J.,
RA Lu X., Maekawa T., Mahanil S., Micali C., Milgroom M.G., Montana G.,
RA Noir S., O'Connell R.J., Oberhaensli S., Parlange F., Pedersen C.,
RA Quesneville H., Reinhardt R., Rott M., Sacristan S., Schmidt S.M.,
RA Schoen M., Skamnioti P., Sommer H., Stephens A., Takahara H.,
RA Thordal-Christensen H., Vigouroux M., Wessling R., Wicker T., Panstruga R.;
RT "Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in
RT extreme parasitism.";
RL Science 330:1543-1546(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCU74732.1}.
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DR EMBL; CAUH01000563; CCU74732.1; -; Genomic_DNA.
DR STRING; 546991.N1JA19; -.
DR EnsemblFungi; BLGH_03757-mRNA-1; BLGH_03757-mRNA-1; BLGH_03757.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000092_2_0_1; -.
DR InParanoid; N1JA19; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000015441; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000015441}.
FT DOMAIN 1117..1194
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1658..1734
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2717..2794
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3257..3330
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3821..3894
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4357 AA; 491684 MW; 420362C85D82C491 CRC64;
MKACSKWLPK FMLPNEIILD INFPFLSSGK VDKERLREIY KMQHQEMTIE NNNPKSKIWN
IVKSVLFEMF GEFPENKRLS AIGLDSLNTI IVASKLRGLG LQISTISVLL AEDINEIVSL
CIDNTGPSSS VILASTEREN SKSELISTNN TDEVESIIPC TPLQIAMILK SVADTNTYQN
WIELSLPATD DCVFLTKALY ELAEFNPILR TGFVESEGPN WFVQIIRPKI PDSCIKSVKV
FDYELEYTQE YFLKYPVRFQ ILSEESSLKV LVHIHHALYD AWSLELLLDD LESLLSMNVL
LKRPSFESVV DSYQKSEIFN SKDSSSMNYW KQHLLKYEPR GLPNFQTRIS KSRGLAAVEL
ESSFLSSELE KAARSLSTSS QSFFQTALAL TLASYLGSSD VCFGTVFSGR TLPVDGIENI
VGPCLTTLPI RIDVSTSRNL SHLIQKLNSI NKSHLEYSQV PLQKIKIASD LEPSQSLFDT
VLIWQQTFHA FEGERKKVLL VDAVDNLEFD LTLEITPLKK RIEIKATYRQ SLLPESQALF
FIQQIENIVG ALILEPEASS KAIFSSLSRN LLSIENGSPE ESWTNISRKT LYSSVEDIAL
TNPDKLAVSF AHSLRDNKIN VQNLTYSELN SQANQIANCL VELGVISNMT ICVYLDISLE
IYTLILAITK IGACFCPIMP DISTEHLDKI LEKFQAMSIV TKSDSRSFFE TYHHSKKVIY
IDELHLSDSP AENLSLSHLD DSYAYVISNY RNTGITKEVF ITQTNILTHL LALESINYLT
KNSRLLQSFF LDFIMSLSDI FLIWRMGGCL CSAKSDMLLA NFEAIAHGMQ VTHLSLTPAI
ANLIDPKNVP HVQQLTIIGE VVSPKILSDW TDRDLRIGYG RLATTSIVTV SSSMTQEDSI
DNIGYLLKNT SAFVLLPEPE GFFPTIRGGV GELCFAGSQI GHEFINKCHE ECSYLESSEF
GRIYRTGDIG RLMPGGSFVY LGRKRDRIEI KGYKFDLGEI ASQLLSKHPN ISNCKSVAIK
DENKIDLKVV CFWTSASKIS TKFQYLETDL DLIRRLYQSL CPKLRNIMIP SAIIQISSFP
IKTSGKIDQS RLIQLFHSLP KKNLDSINQI REPLYNHQWS QLEEKIASAL SEATGKDIQD
IGPDISFYRL GLDSISAVFF SRILQKKSGY QVLVSEILYY PTVIDLSKSI ISSNENSKVI
EPCSRSAKSN FSSEYIATIF ESYQKVGKQV EEILSCTPLQ EAMLSATEVS CEDIYDNHVI
FEVNGDIDKL LSCWNEMIQR HQILRTCFEK TDSVQYPYAQ VVLSSYNLQP DFLSCLSEKK
SYTSKFEPLY SIKILRDSTP KIMVLSMHHA LYDQAALSIL YDEIQSLYHG QALTPVTPFS
PFLSYIDTID RDAADIFWRR VLKNCKFPKF LPKTGHQLKA MTTETHHVTT EYSLNFIKMK
SMKYDTSVLS ILLTIWACII SERLLETDVC FGTVFGGRSI QIPGIDRLVA PCFNTVPSRL
ENMDNICYLQ AFHKLKELIA ETIPFQFSPL RKIQSKVSPD GSHIFDTLLI LQNQPQKLDP
SIWSIVDENL SIGFTLVCEI IPHSADDNLE INLHYCSSTV SNFEAIEILT SFQQKLNEAL
DNPQKPLVSL TVKEKISKKL DQLEETSTQP EIVRTTPECR SDVEKCLLKM ISNYTDIPAS
RITCDTSIFK LGLDSISAIQ VASRLRKQGF DLMASDIVEN PTISRLASFL EDKKEPISVN
TIPNFEDFKL FCRDIICSKY KITLGDIEAI RPCTMAQQGM IARTLHSGGK EYMNAFFLEI
RPEISLTKLK KAFKTACQIH EIFRSGLASI DDKIFPFVMV TRKEVNLPWF ESELRDFGSL
EIDERLFSKP WSIQVKNQDD KITLEFSAHH ALFDAQSIQM FFLDVSKLYR SVEIESRPPI
NSLLGAIISQ NQSDLEQKKQ FWGRDENKII VNPFPSLTPI QSSDKNVYSE QRILKLSVLE
LEQKCRMNSV TIQAATQASW ARLLAFYVGE SSTTFGISLS GRSICENADS ISFPSAITLP
TRCNVMGTNT ELLARTMRFN SEVLRHQFTP LTLIQKWTGS LNSRMFDTLF LYHKMKSSSG
KSELPWKVRR ETSFIDCAVS LEVVSHADNR FSLHLSFGVD LIPVEQARII LEQYEVLLLD
ILSNPDNICA STPQSPINIL SVTAPKNPFI SCPVTLLHQF VERGARLYPE KVALEFVTNF
DSNNISRECW KYEELNDCSN QVANYLLDRH IGPGNMVATC FDKCAEASFA FIGILKAGCV
YLALDPTAPI DRLKFILKDS NAKILLTSGK FKKKLAGLAN IDIIDFDRSL ALSYSKKSPK
LVRSIEPEDT SYCLYTSGTT GTPKGCLITH ENAVQFMLAF SKIFEGRWND DSKYLQFASF
HFDVSVMEQF WSWSEGLCVV SAPRDLILED LSGAIQKLGI THIDLTPSLA QLLHPNDVPS
LCRGAFVVGG EKLKQEILDL WGKHECIYNG YGPTEATIGC TMYPRVPENG NISNIGPAYI
NVGSFVLAPG TESLVLRGGV GELCISGKLV GKGYLNLPDL TAEKFPTLKV FNERVYRTGD
LVRILHDGSF NFIGRVDDQV KLRGQRLELN EINEVIKQIK SIHEVVTSLV RNINQDKDQL
VAFFRTDLSD LSSLIPTIRE RCRYKLPEYM VPSHFIPIKQ IPLNSNNKAD FKQLCNIFNE
LTFDDLQVLH SSGERIKAWS HIENEVVSKI SSAIGLDICA LTRSTNIFEA GLDSISIIQF
CQALQNSGLK NAKLSVVKNN PCLHDLVGVL LQKTQSDENE RNKFIASSQR LKAFSHKHMV
NICDELEIDN SLIEAVTYCT PLQEGMIYRF LESEHAIYFN KFQFQLSEGI EEQKLLIALN
RVVSHLEILR VRFVATEDGF AQVVLKDKIL TWVPIQKYEA LDKISALRSP YSMNYDAGIL
SLCMFHGLYD GYSFRMLFHH IIDEYFGVQN INYGPSFIES LPYGPLATIT GAEEFWKSHL
VDWSPFLFTE NPSSNDVNVT ISRVIYLSGF ENLRRKLRVT AQAIIQACWI TVLQKKFSRN
LTVGVLTSGR SIDLEGADTI VGPLFNVIPY NSKLKSGIQM TEIISHCHKF NISLQDFQHT
PLKEIQKWAP LRNIKSLFEI IFNFQRADHM QDKVNNFCTE IEVAQIFDFP LALEAELGLD
NTSLSLKFFS RSSIIAEDSL DDLASQMEQL IGSTLSEEGT NYVIHESKED MSNAMTVKSL
AQNSEELPTK IEEFTWTKET LALRKEMALL AKVPQDVVDQ NSGIFELGLD SIDTIKLSSR
MKIQGVDISV RAIIKLQTIS RMAPYLDSKI DSLQSSTDGY LRDGYRELKS YFASMKKPTG
DFEEILPATP FQEGIIKEMM SSSFQRYFNI NGYKIGSLVD SERLIGAIRK VIEISPILRT
TFLEIDDPGV PIRFALAIQK MHGDEIETET LSPSETGSIY DYLNHFKKET IIKASQSFKL
FHIRLVVLGP ERFLAIAISH ALYDGTSLSI LHEDIKRAYD GLSIDRPDFR PYLEQSFLSR
TKDAEKFWRT MLSNLPTSVL SRKYDSVFAD SDAKFMSQRP SRIPLSRIEA ACRSSRITLQ
TLGQTCWALV ISQLTQNLDV VFGSILSCRD SEEATRVMFP LMNTVAVRSV IHGSLNDMLT
YMQEMNNKIR KYQHFPLGRA QNYALGSRGG RSRENQPFFD TIFIYQGRID AVDQNPLYES
IYQVSNVEFL ICAEMRIESD NNLWWAITCK EAAHNQAETE MLVEALDKTL ERLISSKNSQ
STIIDGDSVS VCGLPSFKLK HVEPMSQHEE NSTPLEVESW SSTEMSIRTA LSIISRVPEK
NISKHMTIFH LGLDSILVLK LPALLKTFGI QIKISSIMRD QTIAAMAITA QSLSLATHKF
QDEDSILATI KFTGEFPIAR ATLEEEIGNI EYIIPATAGQ CYIIRQWQVS GGVLFDKMLS
FTVPQPLIQE SLASSWRKLL ATHDILRTGF VEDDGKIFQV IFRDPSNPIV YTSEEVDRNL
IRSRDLRFPP LDLCVEMLPG KEVKLHLSIH HVIYDGVSLP LLLEELKRLY HGEELVAMSC
LGFKSLVLQS FAASQSLDLR EKWQSYLPGE TFDLEPATSG EENCRTEVYI PSTEIQDMRL
RAQNIGSSVD ALFLAALAKI KAQRIQHASP AEPVGAVILG LYLANRAPFG EDLSQLAAPT
LNVLPLCIHE PLEKSLESLA LEIQADIQRI SSSDMVFASL SQIYEWTGVR VEIFVNILKP
SIGLIFESGG LLASPLPSVK FGRDRPQSSN SHVQVYEKSL MPRSLPKKEA EAYLPPIDIE
LRYHDGTVDM GIFACQNSLT PDEAKSFATQ FLDFWGF
//
