ID   N1P7R7_YEASC            Unreviewed;      1104 AA.
AC   N1P7R7;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   08-NOV-2023, entry version 45.
DE   SubName: Full=Bud2p {ECO:0000313|EMBL:EIW09140.1};
GN   ORFNames=CENPK1137D_910 {ECO:0000313|EMBL:EIW09140.1};
OS   Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=889517 {ECO:0000313|EMBL:EIW09140.1};
RN   [1] {ECO:0000313|EMBL:EIW09140.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CEN.PK113-7D {ECO:0000313|EMBL:EIW09140.1};
RA   Nijkamp J.F., van den Broek M.A., Datema E., de Kok S., Bosman L.,
RA   Luttink M.A., Daran-Lapujade P., Vongsangnak W., Nielsen J., Heijne W.H.M.,
RA   Klaassen P., Platt D., Paddon C.J., Koetter P., van Ham R.C.,
RA   Reinders M.J.T., Pronk J.T., de Ridder D., Daran J.-M.;
RT   "De novo sequencing, assembly and analysis of the genome of the laboratory
RT   strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial
RT   biotechnology.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CM001532; EIW09140.1; -; Genomic_DNA.
DR   AlphaFoldDB; N1P7R7; -.
DR   HOGENOM; CLU_002973_0_0_1; -.
DR   Proteomes; UP000013192; Chromosome XI.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd00030; C2; 1.
DR   CDD; cd05137; RasGAP_CLA2_BUD2; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          316..444
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          505..721
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1027..1104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1027..1067
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1104 AA;  126663 MW;  451AFC3A78384760 CRC64;
     MSSNNEPAQS RTSYFKLNEF LSNVKHYKNT FKGEIQWCNN LSLNDWKTHY LQITSTGALT
     HSIDELTADS TNIQPIIKHL QQCRIEIIKD KHSSFKDINA NCNFIIQVNT SGKDNKVYLR
     VKSWSDFKKL LTCLIWWSSM KTNGIFNKFQ VSRPLEFKSK KMAKPESLLV YKLNVFGPIV
     KNIVLPPATN ILESPDIINN DDNSVGWFSA MGVLKSNGML DLLLQSDGSL IYSLNISQLL
     RSEIRILDSS VLQSENSLFL GELPLLRSQL GLEKFRIENI ASAATNSSDI SQEIIVEFPL
     RIDLEDCFIA LQSFARSEYL SITGSDKSND MKISNSFKIS ILEANFQSIN LNDKNNTPWS
     IFTDITAWGH TWARTSMVSN SSNPFWREEF QFNELLRLTN SYLEIKQLFH DLNNKKRLRL
     IGKIKITQEI INDTRYNKET RLPIMDVDNK NFQIGTICIK ISSNLNFILP STNFVKLEKL
     LMNANLSMVS NLIYKSSSSM ENDNKLTQTS IIFLDIFQSL SRIEEWFHVL IDKELAKIDG
     TVSRINQKNL DSKHVFNSLF RGNSILTKSI EQYFFRVGNE YLSKALSAIL KEIIESNKSC
     ELDPARVKEK DEVKKRKIIA DNYKRLYSWV TKIWKRLYAT SNDLPIEIRN VLKIFRQKLE
     IICIDDTLQI ILNGISGLLF LRFFCPVILN PKLFKYVSQN LNETARRNLT LISKVLLNLS
     TLTQFANKEP WLMKMNNFID KRHNDLLDYI DKMTQKKLDF NSKILNLSST ISRPKLAIEQ
     TMLDDLPQIP YLLDKNLRET EFVNLIVNFS QEDMTKMEKY NHMDNGGKGE LIEEEGLLSG
     SSLNLSVDKK DLDSPIEVKP EIGELEFEKI TENNTEIFGD DLMNLLKSDD VGSRSRDLDN
     GANSGIKFNS IIPKAEEEKH AMKELEQESC LLYNRINHIR KRLSGYECAS STLFEDKKYS
     ISLSHKIFYE EIKEGKEIVL KLLNKPTNEN SSARLQKFFT KGVSSKSNNT VGDSYCKFLT
     IDVSDENPKS SNKTSVHGTS SENGAKDDYL TLPNSQGKGN LGNRFSPTKL SRIMRKPPNA
     DVPKEQNSRK LTRWFKKKKE TGGS
//