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Database: UniProt
Entry: N1PYS1_DOTSN
LinkDB: N1PYS1_DOTSN
Original site: N1PYS1_DOTSN 
ID   N1PYS1_DOTSN            Unreviewed;       927 AA.
AC   N1PYS1;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DOTSEDRAFT_67582 {ECO:0000313|EMBL:EME48582.1};
OS   Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight
OS   fungus) (Mycosphaerella pini).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Dothistroma.
OX   NCBI_TaxID=675120 {ECO:0000313|EMBL:EME48582.1, ECO:0000313|Proteomes:UP000016933};
RN   [1] {ECO:0000313|Proteomes:UP000016933}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX   PubMed=23209441; DOI=10.1371/journal.pgen.1003088;
RA   de Wit P.J.G.M., van der Burgt A., Oekmen B., Stergiopoulos I.,
RA   Abd-Elsalam K.A., Aerts A.L., Bahkali A.H., Beenen H.G., Chettri P.,
RA   Cox M.P., Datema E., de Vries R.P., Dhillon B., Ganley A.R.,
RA   Griffiths S.A., Guo Y., Hamelin R.C., Henrissat B., Kabir M.S.,
RA   Jashni M.K., Kema G., Klaubauf S., Lapidus A., Levasseur A., Lindquist E.,
RA   Mehrabi R., Ohm R.A., Owen T.J., Salamov A., Schwelm A., Schijlen E.,
RA   Sun H., van den Burg H.A., van Ham R.C.H.J., Zhang S., Goodwin S.B.,
RA   Grigoriev I.V., Collemare J., Bradshaw R.E.;
RT   "The genomes of the fungal plant pathogens Cladosporium fulvum and
RT   Dothistroma septosporum reveal adaptation to different hosts and lifestyles
RT   but also signatures of common ancestry.";
RL   PLoS Genet. 8:E1003088-E1003088(2012).
RN   [2] {ECO:0000313|EMBL:EME48582.1, ECO:0000313|Proteomes:UP000016933}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
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DR   EMBL; KB446535; EME48582.1; -; Genomic_DNA.
DR   AlphaFoldDB; N1PYS1; -.
DR   STRING; 675120.N1PYS1; -.
DR   EnsemblFungi; EME48582; EME48582; DOTSEDRAFT_67582.
DR   eggNOG; KOG2378; Eukaryota.
DR   HOGENOM; CLU_005431_1_0_1; -.
DR   OMA; MAQWVSE; -.
DR   OrthoDB; 4819765at2759; -.
DR   Proteomes; UP000016933; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00882; Ras_like_GTPase; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016933}.
FT   DOMAIN          446..571
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          668..910
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..389
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..443
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   927 AA;  103107 MW;  E0F1343D49106A0D CRC64;
     MPASSPTIGR ESTRRSSKTG GYDTQRFERR EMAKSSQDYT GHHGRRGSRQ DSNTVGSSGT
     AAERALGSGG VVAERPRVKT RTTSAPAPPQ FNDRGMNKGI VSARHGESDA LLSLALQQQS
     QATAGAQSAV VEEGEDEDEL SGVVGKIRTY HPFQDPELAQ PYPEVNIAII GAEGVGKSTF
     IQKALELPDL PPSQSAERKI PIDGSVYLVR LLELPIDNIE INDDETINWP DTIEDKMMPR
     VDGALALYDV KDKASIEDLP EMLDAITKAS LPTVLISCKC DTPADEREVD PAQVEQNAKR
     AINNISTLQI SEYHPETHRR GIFMLLNTIV SAQSEQYFRS SSANRRRATS NAVRPISPRS
     SAILGHARSS SEYTGSLHKD PRRSRHDSTL TTGHGSGDRL RVPHIEDHPM QSSFLLEESG
     SEPSRASSQS SASADPVTLG TTPTSVAFSE NGATFDELVD RLLAQPTSKT DLKFSAIFLA
     LYRKFAAPGR LLEAIVERFN ALEHNGSPQI LKTQTQLRYL SIVEQWAKLY GGDLAYPQTT
     RRLRTFVAKL AAFRIFAQAA REIHADIENV REDDDTDWAF CDKDRETSGF RTSMSSTAST
     LIDDPAFSSE RDLSGSTINE EEPCDRSSNF SNQVMANVEQ AQKQAQRLQS VPRTMITKIQ
     WRALVEQPDD LIARELTRMD WIMFSSIRPR DLVRHCSLSK GQKASCNNLA HVDRMIEHFN
     QLACWVANYV LLRDKPKHRA LMLEKFMRIA RKVRELNNYN ALGAIIAGVK SSSVHRLAAT
     RELLPTAVGK DWMRLEALMA ASRSYSAYRL AWENSSSERI PYLPLHRRDL ATAEEGNKTF
     LGDESEGRIN WKKFEIMGDV IVSLQKAQGV HYSNLETGLG ESIIRELVME VKLVKDEDDL
     YERSVQLEPA ANSALGPGAK FKEFFKR
//
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