ID N1Q5A8_DOTSN Unreviewed; 841 AA.
AC N1Q5A8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=DOTSEDRAFT_41268 {ECO:0000313|EMBL:EME50119.1};
OS Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight
OS fungus) (Mycosphaerella pini).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Dothistroma.
OX NCBI_TaxID=675120 {ECO:0000313|EMBL:EME50119.1, ECO:0000313|Proteomes:UP000016933};
RN [1] {ECO:0000313|Proteomes:UP000016933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX PubMed=23209441; DOI=10.1371/journal.pgen.1003088;
RA de Wit P.J.G.M., van der Burgt A., Oekmen B., Stergiopoulos I.,
RA Abd-Elsalam K.A., Aerts A.L., Bahkali A.H., Beenen H.G., Chettri P.,
RA Cox M.P., Datema E., de Vries R.P., Dhillon B., Ganley A.R.,
RA Griffiths S.A., Guo Y., Hamelin R.C., Henrissat B., Kabir M.S.,
RA Jashni M.K., Kema G., Klaubauf S., Lapidus A., Levasseur A., Lindquist E.,
RA Mehrabi R., Ohm R.A., Owen T.J., Salamov A., Schwelm A., Schijlen E.,
RA Sun H., van den Burg H.A., van Ham R.C.H.J., Zhang S., Goodwin S.B.,
RA Grigoriev I.V., Collemare J., Bradshaw R.E.;
RT "The genomes of the fungal plant pathogens Cladosporium fulvum and
RT Dothistroma septosporum reveal adaptation to different hosts and lifestyles
RT but also signatures of common ancestry.";
RL PLoS Genet. 8:E1003088-E1003088(2012).
RN [2] {ECO:0000313|EMBL:EME50119.1, ECO:0000313|Proteomes:UP000016933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990 {ECO:0000313|Proteomes:UP000016933};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB446535; EME50119.1; -; Genomic_DNA.
DR AlphaFoldDB; N1Q5A8; -.
DR STRING; 675120.N1Q5A8; -.
DR EnsemblFungi; EME50119; EME50119; DOTSEDRAFT_41268.
DR eggNOG; KOG0939; Eukaryota.
DR HOGENOM; CLU_001858_0_0_1; -.
DR OMA; APWIMIN; -.
DR OrthoDB; 1820836at2759; -.
DR Proteomes; UP000016933; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR InterPro; IPR032353; AZUL.
DR InterPro; IPR042556; AZUL_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254:SF67; E3 UBIQUITIN-PROTEIN LIGASE HUWE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF16558; AZUL; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016933};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 459..841
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 808
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 841 AA; 94776 MW; 25A00B2EC8DE70D8 CRC64;
MESTIGSTVV GSLADLVTRY NYQVLHGCGN DACTEVTCHT GNTNTSRRPV RRPKPRTARA
TALCQALSPR PRAHLCKHLI DLDDGSNSGR DEGPRDPSSL IQLLCDTRSV RQLTARPSNV
GLEPELEELH QRHASLSDLL RSAGSAPPLP ADDFVDNADL VDRLMQTSFT WLIDRLPSLT
RAAPWIMINR DIISKGLAYP QRNENMPSDD SYNPWAAILD MLDHGPYLRL IGKTMAVIGR
RSHLENVLHR QDPQRKLYPD PGRQSIALML ASALGKINHA GDVDGSELVT FAVVIWLKKA
FARTWNTNPV FKSGGAIHGI LELLQHLEED MSRRRQTSSL PSDVYEMPLI NAQIDPLTMA
TSYLDWTPTN SNQQHVMQYP IIFSMKQLSL HFRVLCHLLM RRSHSLADAA VMLRGRSGVH
FEEAELFQQL RFSEEHYLLI SVSRDEILED TWTQLWQRRK AELRRPLRVR LGERSELEIG
HDLGGVQIEY FNLVCREVFA AQAQMLTTNS HSGISYFRPG SLQPLYMFEM FGLIVALALY
NGITLPVRLP EVFYTILSRL NKSDSSLHLV GEFQLQDLND TWADEVRSLQ SILNDEVEDL
EYSFPLEANG LRFSVQYPVA RSEPARYELH ISDIMLIDGG RPDASHCNPT YLEWPGWRLS
GPSGEAEVVT AENKTRYVQD YIYHLCYGSV APQLDAFLKG FHGCGLIPRK VLAIFQDHQL
KSHLEGSDHL DIDELKAAAR YDGYEAKSKY IQMFWRVVSS WPEKKQKLLL KFVTAAERIP
ITGASQLTFV IKKAATENLE SLPASSTCFG TLILPRYPTA EILQAKLSLA LMYGSEGFGT
G
//