ID N1Q5Y3_PSEFD Unreviewed; 1006 AA.
AC N1Q5Y3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=MYCFIDRAFT_158718 {ECO:0000313|EMBL:EME87474.1};
OS Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease
OS fungus) (Mycosphaerella fijiensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=383855 {ECO:0000313|EMBL:EME87474.1, ECO:0000313|Proteomes:UP000016932};
RN [1] {ECO:0000313|EMBL:EME87474.1, ECO:0000313|Proteomes:UP000016932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIRAD86 {ECO:0000313|EMBL:EME87474.1,
RC ECO:0000313|Proteomes:UP000016932};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KB446555; EME87474.1; -; Genomic_DNA.
DR RefSeq; XP_007920895.1; XM_007922704.1.
DR AlphaFoldDB; N1Q5Y3; -.
DR STRING; 383855.N1Q5Y3; -.
DR GeneID; 19331958; -.
DR KEGG; pfj:MYCFIDRAFT_158718; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_1_0_1; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000016932; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000016932};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 41..306
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 543..954
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1006 AA; 111390 MW; A0C06E49494AD542 CRC64;
MSDIQLYLLE VDTNKAAAQQ IAQQSANKLE TRQVKLSDVI ASVGAYINDE GDAVMRAKSV
AYLADVLEKV PPRALALQER RLLTGFVLGR MEGDVEGSGA SARALLALEK LGKWDAETAQ
RAMTTFVSHT HPLRQFPLQT DRYAILQLLD LLVARYRPHM KQLHEHDPEW LRAFISYFDG
EKDPRNLMVI FSLVRVPMAE WELGGYAQDM FDAVFNYFPI TFRPPEHDPY GITAQDLKDR
LRDCIAATSD VAPYAFPALL DKLDSTSINT KRDVLVAIQA CVTGYSTNTI HLYSVTLWDA
LKFEIITVQD EHLAKEALKA LALIARKFAN ADAPLNAYLR PIIKECNEHL EDAPTKQSQG
AGRILLAIAK TGSLVADKIA KGILPTLFSL YSSASSIAKR RGLLEVYNHL VDAYLDIQNS
GGEVHPESLH TFVGEATQAM LHALAKAPSA EVSFRLTALQ GLSKLVRARK VLSEEQTGLA
VGAIVDVVLH ERIEGHGDIK DEAIKSLTEI ARSLPDSIRS QAVPAFMVQL PDFAEDRKTY
GPVLEAFAQL SREQQVFDTI ALRIMNKLKA ARYQNAPKHY QKDLLLALLY CFTNGVPLLE
DGVLRSSYFT DYAQPLIQQV REALPSQRDD MTTDIIGRIT NIILRQQTPH FQSTVYNKNV
DWLSSASTDG VGKSTDELRA FAPFLLYYYA AIRPEIAEAN DVLSSLRAQS TYLLGSDTDP
IGFTIALRHV SLLVNKFFDP KAVDKALEDA GLEVSVLLSG GNSTHKLDAA FAVVKALLIQ
GRSGALTSKY LQLLLQNLAV TDRSFARRFA GLLAPDDILT KENHCTVSGL YKQKTFGHTI
PAMIENVKTA EPSVKPNYLI AMSGILRWLP YALMESSLPS LAPSLLQSLD LNDAADQEVK
YSTLTIFESL LMHDAQIAEE HSASLITRLL NSTSTPGNQA KVRAKALQCL SLVPRQLKRE
AVVPYRRPVV KKLLGCLDDG KRSVRHEAVK CRSAWLALDE GTEEEE
//
