ID N1QAJ2_PSEFD Unreviewed; 1117 AA.
AC N1QAJ2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=MYCFIDRAFT_25225 {ECO:0000313|EMBL:EME88896.1};
OS Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease
OS fungus) (Mycosphaerella fijiensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=383855 {ECO:0000313|EMBL:EME88896.1, ECO:0000313|Proteomes:UP000016932};
RN [1] {ECO:0000313|EMBL:EME88896.1, ECO:0000313|Proteomes:UP000016932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIRAD86 {ECO:0000313|EMBL:EME88896.1,
RC ECO:0000313|Proteomes:UP000016932};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KB446555; EME88896.1; -; Genomic_DNA.
DR RefSeq; XP_007919684.1; XM_007921493.1.
DR AlphaFoldDB; N1QAJ2; -.
DR STRING; 383855.N1QAJ2; -.
DR GeneID; 19338419; -.
DR KEGG; pfj:MYCFIDRAFT_25225; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_0_1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000016932; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000016932}.
FT DOMAIN 951..967
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 13..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 124751 MW; 08322BCD98E32E83 CRC64;
MAHDSFCTDK LIETPGTVFS SPSRHAKKKV NYAESDDDDD DDAPFKPVSG NGRAAKRRRI
SVKDDSDDDE FGLDAATLAA MEIDEEMDDF VVDDDLEDDE KPKKPKKKAS ASSSAKASNH
SSVRSPSPSP FREASEEAPT KSTAQQWTFD PDAPPSTEPR KRPTVVKSTS NGPPKKQKAH
ATDPADRYPW LAAIQDADRH TPDHPDYDPR TLYVPPGAWN NFSPFEKQYW EIKCKFWDTI
VFFKKGKFYE LYENDATIGH QLFDLKLTDR VNMRMVGVPE ASLDHWANQF VAKGFKIARV
DQMETALGKD MRERDQKGAA KKKEEKVIRR ELASVLTAGT LVEGSMLQDD MATYCAAIKE
TESEGKPAFG IAFVDTATAQ FHLAEWVDDA DMTRFETFVA QTRPGELILE KGCISARALR
ILKNNTPPTT IWNYLKPDKE FLSADKTRMK MNGEAYFVKS EDDEAADSWP KVLREAETKE
NTFSAYGALV WYLSMLKIER DLITCANFSW YNPIRKASSL VLDGQSLINL EIFANTFDGS
TEGTLFTMLN RCVTPSGKRT LRQWVCHPLA DARKINERFD AVDALNADGT VMDRFTASLS
RLPDLERLIS RVHAGRCKVQ DFVKVLEGFE QIEYTMSLLS SFGDGEGLLG QLISAMPNLQ
TPLNHWKEAF DRKQAKEQGL LIPQPGVEDD FDESQERVDG VEKELNKLLQ RARKDLGSSA
IKFTDNGKEI YQLEVPIKVK GNIPKNWKQM SATKQCKRWY SPELEGLVQD LKEAQEMHAQ
VVKALAGRFF ARFDEDYTTW LAAIKIIGQL DCLISLAKAS SSLGSPSCRP EFIEDDHARS
VLEFQTLRHP CIETTTNFIP NDIALGGDQA SITLLTGANA AGKSTILRMT CIAVILAQIG
CYVPCESARM TPVDRIMSRL GAHDNIFAGQ STFMVELSET KKILAEATPR SLVILDELGR
GTSSYDGVAV AQAVLHHIAT HVGSLGYFAT HYHSLAAEFQ KHPEVIAKRM AVKVDDDIRD
VTFLYHLEDG VAEGSYGMHC AAMCGIPDKV ITRAEQAAEN WEHTGRIKES LEKAMESSWL
PLGLLSDVSW LLKERSEEDE NISDGSLEVL RKAIAAL
//
