ID N1S6F6_FUSC4 Unreviewed; 1233 AA.
AC N1S6F6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=6-hydroxy-D-nicotine oxidase {ECO:0000313|EMBL:EMT72132.1};
GN ORFNames=FOC4_g10003988 {ECO:0000313|EMBL:EMT72132.1};
OS Fusarium oxysporum f. sp. cubense (strain race 4) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=2502994 {ECO:0000313|EMBL:EMT72132.1, ECO:0000313|Proteomes:UP000016929};
RN [1] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 4 {ECO:0000313|Proteomes:UP000016929};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- SIMILARITY: Belongs to the RNase T2 family.
CC {ECO:0000256|ARBA:ARBA00007469, ECO:0000256|RuleBase:RU004328}.
CC -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC family. {ECO:0000256|ARBA:ARBA00005466}.
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DR EMBL; KB726281; EMT72132.1; -; Genomic_DNA.
DR AlphaFoldDB; N1S6F6; -.
DR STRING; 1229665.N1S6F6; -.
DR HOGENOM; CLU_268863_0_0_1; -.
DR Proteomes; UP000016929; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0033897; F:ribonuclease T2 activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.90.730.10; Ribonuclease T2-like; 1.
DR InterPro; IPR012951; BBE.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR001568; RNase_T2-like.
DR InterPro; IPR036430; RNase_T2-like_sf.
DR InterPro; IPR018188; RNase_T2_His_AS_1.
DR PANTHER; PTHR13878; GULONOLACTONE OXIDASE; 1.
DR PANTHER; PTHR13878:SF91; L-GULONOLACTONE OXIDASE 3; 1.
DR Pfam; PF08031; BBE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF00445; Ribonuclease_T2; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55895; Ribonuclease Rh-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
DR PROSITE; PS00530; RNASE_T2_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016929};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1233
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004112144"
FT DOMAIN 726..915
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT REGION 440..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1233 AA; 135090 MW; 769615322AF2F0F4 CRC64;
MAWHAQLALV LGLVCLASAR CTGMSDDCSS NPIPLRQFNP LNFHATTCNL KWNNGCTRNK
NGQLQQKPPP FLLCSSGQFP SGLIPVDAYT LAMQTRGAGS TQQSAKYTLH GLWPSSAGGN
GARDQPYGCL NGEEFDEGIL KTFGDLLSYF WPTDPKFGNT MQCFILSEWM KHGTCAVIPG
ADGNAFRLSQ EAYFRTAFVL ANEFNANAAL RQQLDEPGSE DLESNVSTGC VQCAYLATVD
WEGTDVQSVP RMSGDCVNQC FACGDSWDIC PPAQLNSTVE LDPSNAPVDT SDGGTNSDGL
ANFAVLDFAM PAFISNNTSP WEGTWRSFGA EQGGSGKFQF AQTFTDKVLT VTTDSPYPQT
CSYERLGPKE LVLRCGGNRL EECLVQRLPD IGGLEAAFLA CNHTGQPAPA SFYTAMDTPG
CGNFLMFRCK ASAEGCSFSP DATSAASKSK TKTNSGSDSE PSLVSHSQPG IAGAPTKLLG
LWRSLQVSSH YEEGLANWSF TSDGQASVKW PNHPERGVER YSVSHSREDP SRVLLATASG
AITTCRFKFQ YQPVYSYAVL DCTAGDKKVQ WAMGRCNPCS AECRYSCSAE NDNCGAGSCD
PSESSSAGAL PSPQGDSDHR WCTPEDSSCW PTKTAIDKLE KALDPTVPRL GVQWSNYPAP
QPAPVPTGSI NNQAFYGLGS KGLKALYYYE DIAEMQRPCF NIKDGVNIWN TASDMCKAAL
HQNEYRNWNP FIVVFPLNQR HITAALKFAA QHRLCIATAG TGHEYNSRNS CPTGGILIRT
ILLKNKEFLP TWNEDPALAP AGAFRFGAGS IFAEMHAFSA KYDRVVASGW CSTVGMTGYH
LGGGHGPFAP SMGLGVDNVL EIEVLQVGRN IHGQTVVHKK IVSRRKNPQL FWAMRGGGGG
VWGVILSMTL RAHAVPDGGL SRVFMSQTGT FCPGSQNKFG YEWLREMWPR FAEWQLRLNS
KVSTQPGFFI DTSKYKKGDL CTATWTFNFE YFYAGGQKEQ DYVMFRDSLK DVLQTKTVQE
DNFSSAYDYL LSMPPNKFQI TVMNPLPAPH EPSDDATGSQ NSVFVSREDM ETKFASTMMD
VLDICVNSLK TPDKTSPDPM GYRCGFHYLY TSITGNLGSA QPGDTAISPG FRSGLMLWNA
RTLSTKQCED TIYKLGSNSY FSESSYVMHN WTDRYWSEKK YKQLLAVKRA HDPGNLFWCH
HCVGDDPDDA YGNPLGVKKA QDVKVDSYKK DEL
//
