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Entry: N1V192_9MICC
LinkDB: N1V192_9MICC
Original site: N1V192_9MICC 
ID   N1V192_9MICC            Unreviewed;       582 AA.
AC   N1V192;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:EMY33832.1};
GN   ORFNames=D477_012725 {ECO:0000313|EMBL:EMY33832.1};
OS   Arthrobacter crystallopoietes BAB-32.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Arthrobacter.
OX   NCBI_TaxID=1246476 {ECO:0000313|EMBL:EMY33832.1, ECO:0000313|Proteomes:UP000010729};
RN   [1] {ECO:0000313|EMBL:EMY33832.1, ECO:0000313|Proteomes:UP000010729}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BAB-32 {ECO:0000313|EMBL:EMY33832.1,
RC   ECO:0000313|Proteomes:UP000010729};
RX   PubMed=23833141;
RA   Joshi M.N., Pandit A.S., Sharma A., Pandya R.V., Desai S.M., Saxena A.K.,
RA   Bagatharia S.B.;
RT   "Draft Genome Sequence of Arthrobacter crystallopoietes Strain BAB-32,
RT   Revealing Genes for Bioremediation.";
RL   Genome Announc. 1:e00452-13(2013).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMY33832.1}.
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DR   EMBL; ANPE02000150; EMY33832.1; -; Genomic_DNA.
DR   RefSeq; WP_005269591.1; NZ_ANPE02000150.1.
DR   AlphaFoldDB; N1V192; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000010729; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:EMY33832.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010729};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..120
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          195..322
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          385..531
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   582 AA;  61740 MW;  58525C8E77109073 CRC64;
     MAQELASQLI DQLVSAGVRR IYGIVGDSLN PIVDAVRKTG GSAKGGIDWI HVRHEEAAAF
     AAAADAQLTG ELAVCAGSCG PGNLHLINGL YDANRSGSPV LAIASHIPSK QIGTGYFQET
     HPDRLFTECS VYSEMVSTAE QAPRVMHSAI QHAWGRRGVA VVSLPGDIAS LDAVAPTPVC
     TPFLPASVVP DPRSVEQLAK AINDAGKVAI FAGAGVAGAH DEVVALAELI GAPIGHSLRG
     KDFIQYDNPY DIGMTGLLGY GAAAEGIEDA DLLLLLGTDF PYDQFLPETR TAQVDRAAEH
     LGRRTDVDLA VHGDVLPTLT ALMPLLKRKK SRRFLDQMLK KHDKLMNKAV GAYTRKADKL
     KPIHPEYAAS VLDQTAAADA IFTADTGMCN VWTARYINPL GTRRLIGSYL HGSMANALPH
     AIGAQFAHPR RQVISVSGDG GLAMLLGEML TAVTYKLPLN IVLFNNSTLG MVKLEMLVDG
     LPDFGVDVPD TNYAAIASAM GFHAVRITEP SELEGAYRAA FAHRGPSLVE VITDPKALSL
     PPKITGEQVF GFATAMSKLV LNKGAGEAVS MARSNLRNIP RS
//
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