ID N1VMR8_9LEPT Unreviewed; 275 AA.
AC N1VMR8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN Name=pyrF {ECO:0000313|EMBL:EMY59743.1};
GN ORFNames=LEP1GSC203_0300 {ECO:0000313|EMBL:EMY59743.1};
OS Leptospira terpstrae serovar Hualin str. LT 11-33 = ATCC 700639.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1257025 {ECO:0000313|EMBL:EMY59743.1, ECO:0000313|Proteomes:UP000012371};
RN [1] {ECO:0000313|EMBL:EMY59743.1, ECO:0000313|Proteomes:UP000012371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT 11-33 {ECO:0000313|EMBL:EMY59743.1,
RC ECO:0000313|Proteomes:UP000012371};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Hartskeerl R.A., Ahmed A.,
RA van der Linden H., Goris M.G.A., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001419};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMY59743.1}.
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DR EMBL; AOGW02000023; EMY59743.1; -; Genomic_DNA.
DR RefSeq; WP_002975655.1; NZ_AOGW02000023.1.
DR AlphaFoldDB; N1VMR8; -.
DR STRING; 1257025.LEP1GSC203_0300; -.
DR OrthoDB; 9808470at2; -.
DR UniPathway; UPA00070; UER00120.
DR Proteomes; UP000012371; Unassembled WGS sequence.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04725; OMP_decarboxylase_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011995; OMPdecase_type-2.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR02127; pyrF_sub2; 1.
DR PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EMY59743.1}.
FT DOMAIN 21..259
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 275 AA; 30974 MW; 2EE2487F118CE28D CRC64;
MNHRSEFIQK FNLRRDSLQS LLCIGLDPEL DKLPKVSLES KAPLVHFTET IIRYTHSYAT
AWKPNVAFFE RLGAEGYFAL EHMVQVMKEV SPDVPIVMDA KRGDLANTSK EYAKYFFQTL
QVDALTVNPY MGRDSLVPYL DLGGYIFVLG LTSNPSSSDF QKQKLVGKDI FLYEEVSDQM
ARLGEEYPNQ VGLVVGGTHP SEIQSLRKRH PEMYFLIPGF GAQGGDLNSI VQTSGKRSLI
NSSRGITLST LDENFGQVAK KKAEEVHLQM NQLFL
//
