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Database: UniProt
Entry: N2A759_9CLOT
LinkDB: N2A759_9CLOT
Original site: N2A759_9CLOT 
ID   N2A759_9CLOT            Unreviewed;       456 AA.
AC   N2A759;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=C824_05087 {ECO:0000313|EMBL:EMZ21905.1};
OS   Clostridium sp. ASF502.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=97139 {ECO:0000313|EMBL:EMZ21905.1, ECO:0000313|Proteomes:UP000012582};
RN   [1] {ECO:0000313|EMBL:EMZ21905.1, ECO:0000313|Proteomes:UP000012582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ASF502 {ECO:0000313|EMBL:EMZ21905.1,
RC   ECO:0000313|Proteomes:UP000012582};
RX   PubMed=24723722;
RA   Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT   "Draft genome sequences of the altered schaedler flora, a defined
RT   bacterial community from gnotobiotic mice.";
RL   Genome Announc. 2:e00287-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EMZ21905.1}.
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DR   EMBL; AQFU01000085; EMZ21905.1; -; Genomic_DNA.
DR   RefSeq; WP_004071717.1; NZ_KB822444.1.
DR   EnsemblBacteria; EMZ21905; EMZ21905; C824_05087.
DR   PATRIC; fig|97139.3.peg.5547; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000012582; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000012582};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012582}.
FT   DOMAIN      142    276       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      363    432       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     150    157       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   456 AA;  51538 MW;  A7F3682D19D30B8D CRC64;
     MNIVEENWPQ ILKKMKTEYC SSNIAYTTWI EPLTVYELSE DTVYILVKLK ASLEHIEEKY
     MLPFKVCIAE VTGYEYEVSF VTEDNAVIHR KKAIAAKKQK SSAVLESANL NPKYTFDTFV
     VGSNNNFAHA ASLAVAESPG DIYNPLFIYG GVGLGKTHLM HSIAHHILEK DSSKKVLYVT
     SETFTNELID ALKIGKNGNE LAMTTFREKY RNNDVLLIDD IQFIIGKEST QEEFFHTFNH
     LHVSGRQIII SSDKPPKDIE TLEARLRTRF EWGLIADISS PDYETRMAIL RKKEELDGLE
     RYHIPDDVMQ YIANNIKSNI RELEGSLNKL IALSNLEKKP IDIALAAEAL KDMISPDNIR
     EITPELIMDI VSEHFNVSIA DLKGRKRNAE IVLPRQIIMY LCREMTDTPL KAVGALLGGK
     DHASISHGVK KIAADLETDE ALSNTVSIIR KKLNPL
//
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