ID   N4U1H5_FUSC1            Unreviewed;       760 AA.
AC   N4U1H5;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=alpha-glucosidase {ECO:0000256|ARBA:ARBA00012741};
DE            EC=3.2.1.20 {ECO:0000256|ARBA:ARBA00012741};
GN   ORFNames=FOC1_g10012036 {ECO:0000313|EMBL:ENH69678.1};
OS   Fusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium oxysporum species complex.
OX   NCBI_TaxID=1229664 {ECO:0000313|EMBL:ENH69678.1, ECO:0000313|Proteomes:UP000016928};
RN   [1] {ECO:0000313|Proteomes:UP000016928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RA   Fang X., Huang J.;
RT   "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT   banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000016928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RX   PubMed=24743270;
RA   Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA   Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA   Fang X., Peng M., Huang J.;
RT   "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT   oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL   PLoS ONE 9:E95543-E95543(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-
CC         glucose residues with release of alpha-D-glucose.; EC=3.2.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001657};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC       {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR   EMBL; KB730216; ENH69678.1; -; Genomic_DNA.
DR   AlphaFoldDB; N4U1H5; -.
DR   STRING; 1229664.N4U1H5; -.
DR   VEuPathDB; FungiDB:FOC1_g10012036; -.
DR   HOGENOM; CLU_005043_1_0_1; -.
DR   OMA; FNTWHYG; -.
DR   Proteomes; UP000016928; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd06595; GH31_u1; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR048395; Glyco_hydro_31_C.
DR   InterPro; IPR000322; Glyco_hydro_31_TIM.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR   PANTHER; PTHR22762:SF89; ALPHA-XYLOSIDASE; 1.
DR   Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR   Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|RuleBase:RU361185};
KW   Hydrolase {ECO:0000256|RuleBase:RU361185};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016928}.
FT   DOMAIN          193..498
FT                   /note="Glycoside hydrolase family 31 TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01055"
FT   DOMAIN          507..597
FT                   /note="Glycosyl hydrolase family 31 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21365"
SQ   SEQUENCE   760 AA;  87044 MW;  5B7C3ADDBBFF19BE CRC64;
     MEGYAIPTKP VANKDSIVSG SQWRFTLIND IVLRYEWAED GVFEDRPSTF ALNREFSTPK
     FTVSDTDDQL EIRADAFQVT YNKKRFDKYG LVVSFSNKNT LWGADWRYGE TPQNLGGTAR
     TLDEVNGRCE IEPGILSRAG YSVLDDSNSM LFDSSGFTAP RRPGDRIDGY LFSYGYDYKA
     AMKAFFAISG KQPRLPRWAL GNWWSRYYPY TDEEYLKLMD KFEAEKVPLS VAVIDMDWHQ
     VHGDHIPHAG WTGYTWNKKL FKDPKAFTKA LHDKKLKVTL NDHPHAGVHH HEEQYEAMAK
     DLGHDTSDKA PILFNPVDKK FMHSYLNTLH RSLENDGCDF WWIDWQQGPY SRVRGLDPLW
     LLNHYHFLDN EKQNGEGKAI IFSRFGGPGS HRYPVGFSGD SIMTWESLEF QPEFTATASN
     IGYGWWSHDI GGHMGGYRDD ELATRWVQYG VFSPIMRLHS QMGLFTSKEP WLYRPEFAEV
     MQNFLRLRHR LIPYLYTMNC ASSSNDEPVV QPLYWKFPER DEAYGKPNQY YFGSELVVAP
     IVKPRDKRTN HGAVDVWVPP GRHVDIFTGT IYDGDRDIRM FRSIKNMPVL AHEGSIIPLD
     ANPAPNNGGE SPKNFEVLPK GKAWSIKFLS IMEVPKGFKV VSGVTDQTVL DVEPYVEEYP
     NVPGLVVQIP VLPDKLDTVS IQLGDEPKLS VIDPLKRIQD LILDYQMDMW TKEKLWGVVK
     APQPTAVKVG RLMTLGLDEE LLGPVMELLM ADSRYETCSN
//