ID N4U2E6_FUSC1 Unreviewed; 492 AA.
AC N4U2E6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=FOC1_g10002023 {ECO:0000313|EMBL:ENH62966.1};
OS Fusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1229664 {ECO:0000313|EMBL:ENH62966.1, ECO:0000313|Proteomes:UP000016928};
RN [1] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; KB731257; ENH62966.1; -; Genomic_DNA.
DR AlphaFoldDB; N4U2E6; -.
DR STRING; 1229664.N4U2E6; -.
DR VEuPathDB; FungiDB:FOC1_g10002023; -.
DR HOGENOM; CLU_013399_0_1_1; -.
DR OMA; TIWTLYR; -.
DR Proteomes; UP000016928; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ENH62966.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016928};
KW Transferase {ECO:0000313|EMBL:ENH62966.1}.
FT DOMAIN 117..246
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 492 AA; 53691 MW; 039B5E359B63160B CRC64;
MDEGIGMLLL LEDKKKLTIG IEELELNDPA ANKSTRSSCA PFSGKPAPKN SIPFYNVLWA
ELSNDQITID YAHHASKTLI KPKKWVFTLA KDDESTSGTP AEIFVKTLMT RAYGNAQSQK
RAYVLINPNS GPGGAIFQAA KMQIDPVILK HGGEAVELAQ NADLSRYDTI MACSGDGTPH
EIFNGLAKRP DAARALSTMP VSHIPCGSGN AFSCNLYGSH RPSFAALAII KGVVTPMDLV
SVTSGHNRII SFLSQTLGLI AECDLGTEHM RWMGSARFEV GVVQRMFKKK CYPFDLAVKV
EIEDKGDVKA HYKHHASSAS LNHLAKKLDA DPVAEDAGLP PLKYGTIQDD LPEGWELIPY
DKVGTFYAGN MAYMSPDAPF FAASLISDGL MDLVTIDGDL PFFTAIKVLL DVEAEKLFDN
PHVTYKKISA YRIIPRDQED GYISIDGEKC PFGPFQAEIH QGLGRVISKS GKYEAAGPKN
WDKVTLADRI HG
//
