ID N4UC18_FUSC1 Unreviewed; 1595 AA.
AC N4UC18;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Integrase catalytic domain-containing protein {ECO:0000259|PROSITE:PS50994};
GN ORFNames=FOC1_g10001626 {ECO:0000313|EMBL:ENH66346.1};
OS Fusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1229664 {ECO:0000313|EMBL:ENH66346.1, ECO:0000313|Proteomes:UP000016928};
RN [1] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; KB730415; ENH66346.1; -; Genomic_DNA.
DR STRING; 1229664.N4UC18; -.
DR VEuPathDB; FungiDB:FOC1_g10001626; -.
DR HOGENOM; CLU_001650_18_4_1; -.
DR OMA; AIDFHDF; -.
DR Proteomes; UP000016928; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR CDD; cd09272; RNase_HI_RT_Ty1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR013103; RVT_2.
DR PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR42648:SF11; TRANSPOSON TY4-P GAG-POL POLYPROTEIN; 1.
DR Pfam; PF07727; RVT_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000016928};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Transposition {ECO:0000256|ARBA:ARBA00022578}.
FT DOMAIN 589..754
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 16..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1595 AA; 181752 MW; 67FAEABE02CAC48E CRC64;
MSLHLWEFID PESDETLMQR PERPNVGAYS RRVPPRPADP DLAPSGVQTR RGGQSKTVDP
HHHARNVSEL TAEDKATFTF EWRVYEQDHR EYKEQEANCE KLKAWVTETV DYGLRQSSCR
AIWDLRTWYT NLKTSVGATQ REQQIAARRN YQAAITPLAK IPKDFANWIT AWEMATNHAL
VMKTGGVDDP NTWFDDLAKA IQPVLGNWVT IYTGIYKDKL EGKTLTIGEV AKDLRKEVER
QTLIQPQKGH RVTKGAFGPT FAGESSTLSQ TRAGTPEREI RPRNHGEASG RKRKARQGSP
AARKRVAPSA DSDSRCQACE GNHALSSCYY VFPEKAPEYF KSRKLVCDAV EHRLKTDQHL
KTEVDCIKNF VIASFNLMLS TTHYPLVNSA ILDSGSTIHI FNNIDRFSKF RHAEPGDFVL
AGEGRVPVQG YGNVVIRAHG PRGSKFLRLN DVVFCENFPC NLVSLRQLRK RGYWWDNRPG
YNCLREWNGA LVCNLVDQHD QFVIEDLPPD ISKTSFITRQ HKLNSWTDRT SKVDARKWHL
RLGHPGPQAL EHLVNTTRGT RIKGPTTVEC DDCAISKISR QISRRPREVG HTPGERLAVD
FHDLVRDWGG RTSVMLITDR WSGMIWDYYL ADRHTGTLIT ALKDLFGLLE RQYQLKPKIL
ECDNEIPNAG TVFEFLRTLH IKVEPSAPYT QAQNGGAEVS GKIIKNKARA MRAGARLPED
LWVEIYRAAV YLYNRTPRYT HNWRTPYDKF HTFLAHRDGI VVEDRKPYQA HLRVYGCKAF
AMTREAKTKQ QKKHRLNPRA WIGFLVGYQS TNIYRIWNPH TGVVVPTRDV IFNEDEHFNG
DINQLKDDLL HIGRQELIDL LSEVEEPAVD HDVIVEEEPD GAHISQQNWE SSPGEDEELE
PDTGWEDPVL QAEVGDTGAE QSDGWLDHPT ITDEGSGITG DADTGTGKPE SDTRSQAEAG
SDTRILSART RQYATPVSLP PTALLSMTSG GDSDDLTEKG RLTFTSRLGP IEAWKAAFAA
GRQAAVVGTI NGRRIDKAKL HRMFKNPQQL HRRQMPPLPR HHGDLATHPM GSLFQEAEAE
HLRSHEEMRS WTEIQQLDPR TRNQQVLDCM WVYVYKFDKH GRFKKCKARL VVRGDQQLEP
IHEETYAATL AGRSFRTLMA IAARFDLELI QYDAVNAFVN AKLDKPVFMR MPPGYRKPRT
VLMLQKALYG LRESPLLWQK ELTATLSELG FQPVPHEPCC MTKDGIIVFF YVDDIVLAYR
KRREDVVQRI TRALQNKYKL TGGSPLQWFL GIEIIRDREK KLLWLSQSDY IDKIANLADR
TDLQHDVPMR REELLPYEEL ASLASIRRYQ RKTGSILYAA VITRPDVAFA ASRLARHNSN
PGPEHHAAAD RVLLYLKTTK MLALQFGGDD VFTVASDASF ADNALDRKSS QAYVMRLFGG
TVGWRANKQA TVTTSTTEAE LLALAQAAKE AMFVSRLIKQ LGIHLDEERI QIQCDNQQTI
QLVHKDIARL QTKLKHVNIH DHWLRQEAQR NRIKVEYRPT TDMIADGLTK ALTRTTFRKF
VNHIGLVDIS DQLDNRHTRA LNEEDLQHRI GAIEL
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