ID N4V0P6_FUSC1 Unreviewed; 619 AA.
AC N4V0P6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN ORFNames=FOC1_g10010066 {ECO:0000313|EMBL:ENH74646.1};
OS Fusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1229664 {ECO:0000313|EMBL:ENH74646.1, ECO:0000313|Proteomes:UP000016928};
RN [1] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; KB730034; ENH74646.1; -; Genomic_DNA.
DR AlphaFoldDB; N4V0P6; -.
DR STRING; 1229664.N4V0P6; -.
DR VEuPathDB; FungiDB:FOC1_g10010066; -.
DR HOGENOM; CLU_011781_2_3_1; -.
DR OMA; EPGMILS; -.
DR Proteomes; UP000016928; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ENH74646.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:ENH74646.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016928}.
FT DOMAIN 9..144
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 327..545
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 556..618
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 619 AA; 68424 MW; 56506FC90C69BA89 CRC64;
MTKLDTTSRL TRLRGLMKER NVHIYIVPSE DSHSSEYIAD CDARRAYISG FTGSAGCAVV
TLDSAALATD GRYFNQATSQ LDSNWTLLKQ GLQDVPTWQD WSAEQSSGGK NVGVDPTLIS
GSTAKNLAEK IRKNGGAELV PVDGNLVDLV WGDERPSRPS EQVIIQPDEL AGESVLNKLT
KVRQELEKKH SPGFLVSMLD EIAWLFNLRG NDIPYNPVFF AYATVTPDAA KLYIDEAKLD
DKCRSHLTSN KVDIKPYEAI FDDAQALHAA HAEKSKSGDK VPTGNFLISN KGSWALKRAL
GGDSSVDEIR SLIGDAKAIK TEAELKGMRD CHVRDGAALI QYFAWLEDQL VNKKATLDEV
QAADKLEEHR KEKKDFVGLS FPTISSTGAN AAIIHYGPER GNCATIDPEA IYLCDSGAQY
RDGTTDTTRT LHFGKPTDAE REAYTLVLKG HISLDQAIFP KGTTGFALDS LARQHLWKNG
LDYRHGTGHG VGSFLNVHEG PIGIGTRVQY AEVALAPGNV LSNEPGYYED GKYGIRIENM
VLVKEVKAKH SFGDKPFLGF EYVTLVPYCR NLIDTTLLTS EEKEWLNTYN AKVLEKTQEY
FEGDNVTLAW LKRETQHIE
//
