ID N4WMP0_COCH4 Unreviewed; 978 AA.
AC N4WMP0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0000259|SMART:SM00853};
GN ORFNames=COCC4DRAFT_178761 {ECO:0000313|EMBL:ENI00635.1};
OS Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665024 {ECO:0000313|EMBL:ENI00635.1, ECO:0000313|Proteomes:UP000012338};
RN [1] {ECO:0000313|EMBL:ENI00635.1, ECO:0000313|Proteomes:UP000012338}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C4 / ATCC 48331 / race T {ECO:0000313|Proteomes:UP000012338};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000012338}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C4 / ATCC 48331 / race T {ECO:0000313|Proteomes:UP000012338};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KB733473; ENI00635.1; -; Genomic_DNA.
DR RefSeq; XP_014074544.1; XM_014219069.1.
DR AlphaFoldDB; N4WMP0; -.
DR GeneID; 25840600; -.
DR HOGENOM; CLU_005415_0_0_1; -.
DR OrthoDB; 9570at2759; -.
DR Proteomes; UP000012338; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 2.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 2.
PE 3: Inferred from homology;
FT DOMAIN 697..917
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 405..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 107784 MW; 1562998E750A1B73 CRC64;
MPDASGQTIL PLPDHAVAQI KSSAAIVSLA GVVLELVKNS LDAKATRVEA TVDFVRGGCI
VEDDGLGISP LEFSDKGRLG KLYCTSKYHA KEPLLGRNGT FLASLAAMSL LTIASHHHEY
RSQNAVTFHH ASVVERQLPA SAHHEVHGRH GTRVTVRNLF GNMPVRVKQR ALIAAQKEEY
EKMCEGLKHD IAGLLLGWQG TVSVRVRDGD NKPILNLNTT ARTDQIIGKV RSAQLTSLLN
ILTQANYIGI DEWSSWVPAS ASTSTVSVKG AISLDPAPSK HVQFLSLGIR PLSSDSRHNE
LFDHVNRLFA HSSFGTVEEA VVDAYEKMRQ QSDKRFKKDG YTNRQLKMRK DVDRYPMFHL
RISLAEANGI AISEDQIIGD EANLQSIMDV LEAMITQWLV VHHFRPRQSR KRRDPPDTAS
SLSSVTAASD SSALSRSVST GELLVPENKS ACIGTRKRKR SKDSNSHENF KKHHQAFATW
SRIKSGKSEF FNSLPTRPKL GSQSGNERNS RSAVQSSGGN EPFASFAMQP IAQGAFGAPT
AQNVLPNMGE TFNAEEKEND DSILWTDPST GKTHLLNSRT GCVMSNVQAR PNTDRSPNTF
RFDQRPISKS VRLPSRASTA TAKPTPWLDN MLQNWENPIF KPSEQRIQQI TNDQDKLSHH
HNQVMHSCSH LMDISFETNT TSITSKFSKS GLQTAQVISQ VDRKFILVKM QPASQSNDIL
VLIDQHAADE RIQVESLFQQ LCTPSSLHTY SSSQLGHKSD ISSLALEKPL SFAVSPHEQA
LFITHAARFA AWGILYDIPA SALSSSNQAS LDARKKKRKC EALLLVTALP PVIAQRCVTD
PKVLISMLRS AVWGYAEGHL PPPPSSTPSS FPEKEEEEDT TKEDKSWVRA LSSCPAALVN
LINSRACRSA IMFNDELSLA ECRELVEKLA ECVFPFMCAH GRPSMVPLVG LGERAACALG
DHSGSGKSFV QAWKDWKR
//
