ID N4XCQ2_COCH4 Unreviewed; 3853 AA.
AC N4XCQ2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=COCC4DRAFT_156849 {ECO:0000313|EMBL:ENI10784.1};
OS Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665024 {ECO:0000313|EMBL:ENI10784.1, ECO:0000313|Proteomes:UP000012338};
RN [1] {ECO:0000313|EMBL:ENI10784.1, ECO:0000313|Proteomes:UP000012338}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C4 / ATCC 48331 / race T {ECO:0000313|Proteomes:UP000012338};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000012338}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C4 / ATCC 48331 / race T {ECO:0000313|Proteomes:UP000012338};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UPL family. TOM1/PTR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00034494}.
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DR EMBL; KB733444; ENI10784.1; -; Genomic_DNA.
DR RefSeq; XP_014084693.1; XM_014229218.1.
DR GeneID; 25839473; -.
DR HOGENOM; CLU_000215_0_0_1; -.
DR OrthoDB; 164548at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000012338; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR PANTHER; PTHR11254:SF67; E3 UBIQUITIN-PROTEIN LIGASE HUWE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF06012; DUF908; 1.
DR Pfam; PF06025; DUF913; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF14377; UBM; 3.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 3517..3853
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 215..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1458..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1865..1903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1934..1976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2216..2279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2310..2405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2505..2539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2689..2781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2848..2872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2923..2946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3149..3221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1486..1500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1504..1524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1883..1903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2262..2279
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2385
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2689..2726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2727..2766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3158..3188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3196..3219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3820
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 3853 AA; 429371 MW; 268F074A4F422AA2 CRC64;
MKIKKQATSR HESTLSSMIA DFVKATESIP LYQLPAHLAS FPKHWPFPRG DAYHWIPALD
RFDHILDLFN KEYGLVDGPQ TQPFQRRLLL KGDADQGSTA SDQTTTEAVL DTLHLSQDGD
RELIEQILNF TRMLLENCGN RSLYSSSERL DKLLNTTSTS LLKATLRLGH RLAQRYAAAR
MRHAPATLHP SALSSHYNIN LDKVQKLSSP FAKGPTAPAP VFGTPAGRGK DRAGGADRVS
PSDLVGMYSL SDAAMKQEFG GVLISYYEPA PATEEGSSKP ATTETPASAP TTPTPVRRTS
SMGPNRTPRQ PQPVAPAESP NTPVFTPGQP SSKTNGPKTF EFSVDKVAKG DIHDLIKEGL
ESLPESVHYE FLHKLRIAKL FNNGAAGRDD AVAIRLLSIA NIGYVHIEKE FMAKLGQQDA
DEPRRLQLAH QLSELVHPPS NGQGGLSLEL QTFTMNALEA LAKHKSKAAD ICAALNVNVN
HGVLFYVVRK LVAGLGEETG DPDDLEEDAW RDALFSLLNT LPTSQTRTGE QMVAAGLLEI
LVDVLKLRTA KAERNHPKIL NFLDTFVYNL RDAFSALVAA KGLEIIADLM QYEVDVSKKL
AEEDKGMPKE YKTQLTDYQI PFYHQQSLRW LFKFLNHMMT HTGGNFDRLM RNLIDSPQLL
SSLRTVLSNA KIFGSTVWSM AVTILANFIH NEPTSYQVIA EAGLSEAFLE TVAGEPASES
TAAANANENA ATSTSRPPQE AEKPLAKGIL PVAEAISTLP QAFDAICLAE AGMKLFQSST
ALERFFEIFE SPAHVKALDA DAEMPTMIGN SFDELVRHHP PLKGRVLSCL SELIARVVQL
CASKAEKEGV GAKLWTEDAN GKLLVAGGRQ ALSGSGPQRT SGSTGTDVEM KDADETPNEY
IRVLCRFLSG FFSNHAMCAA YIELDGVDSI LDISNLACLD PKSSENRSMC EQFGHVVQVL
VEQKPHIAVP SLIRRTQQAL ERLQPLLDHT GKQAFFVPFT SSSNSPDNEH LQRGTQYVKA
LVSAHTLVGA MTLTFQSQMY STRSAHNVSS QVNLADMYAR LVDSLGKLHR SCVWEELLLQ
RNMPTEWEKE TRVASSGFGN DEADHVFRIG NSATESPSNA ETAPATAGAT AENPTLSHNS
ARFKNTQTLR NLLSKIPTEI APFFQSLGKL LLFRRSLEAY QRQCATVVAD QLAQAVIDQL
EYEGPKESDN IEDRYAYWIV ILTSLSQLII EPNLDRPQAL TLLLVSFRNL GGFDVLANIL
NQFYESALEI TQKQSEDTSE EMKRLLNLSL GGIKIILAFF SQIINYKVIG ESPQTSSMQT
RPDRDRERSD YFLTAQFLVE LRFAVIKPVE KIWNSNLIDK ATSSIVKTSV NILKSVLECD
GEHGAYKSID KIPKRSKPII KPWSARNGEH LMRLKDNGYE ESLAEEALYR CCDNYNMANE
YCRNQGRLSV SRNPIPQYEI QARGPPSSSP SRAEVVVPEH TDDASMTSSE ITRDEDEPQE
PETQSVQMED ADTSAATESE APTSATPKRM AIGNLTEPVA LDQLDEQRSK LRQNLVDRSL
DVLNSHEDVT FELADLISAA VLKAPEPESM RTEIGTTLVQ SLISLQSEDD FRTQSKKIAA
SAHLLALVLQ EKDFYDVVVG ELKDNFTTLL GFLKIFPDQS AEDSSPWIGQ VLLIIERLLA
EDQLPRQITW TPPTEETQES TSVDELPEPI VTVEEKDQLF GAIIEMLPRI GKDESLALSV
TRVLAMLTRT RKIATRLAEK RNVQRLFLMV KQLAGISNEG LRSAFMIVLR HMIEDDEMIR
QIMRTEIQQM FESRDRRQTD TTGYTRQMYA LAIRAPEIFV EVTNEKLQLA RFDPNQRPQT
LVLKKVETTS TEPANTAETS DVVAEADKPK ESSEAPKQPF LERTKTSDLK VPVVENPDGV
IHYLLCELLA YKEAEDKPEP PKPTETASGE PGTTESSSDA AAASTTASTE PAKTEKPVFK
ADSHPIYIYR CFILKCLAEL LQSYNRTKIE FINFSRKADP YTVTPSKPRS GVLNYLLNNL
VPIGTLNHEG DLSFKKKLAT SNCAIDVIVS LCNKTGEHTL PKTDVPLSPY AETEPDLLFV
RKFVLEHALK AFKDANASDE PLDMKYSRLL SIADIFSRMV SQRPNGEMLT QNADLTPNLK
QMGKIMYEKN FITILTTAIS DIDLNFPNAK RVVKYILKPL RWLCYVAMDL SMHYDTSSTP
DSGDEYEIST ASDDDLVENI REETPDLFRN STLGMFEPPH ESESDEDSED DEGEEMMYDD
PYADDMEYDE AEIGDDDVVS EDDEEILEME IDGMGPIEGL PGDVDDDSEE DDEDDEDDMD
DMDDMDDEGD DDMEDMEDAL EEITADDENA SLAEDQEDEW SDEQDDFPGG VNGEAGMPPG
IGFVIDPPQQ LLEQMRQQGG GDIEDFLDDE MGEEDIDDEE EEYDEDIHYD PGAEDDEEGL
PELGWGGGWE DPAPAAVRHT HRLSPWMFPA GPGDRILVPA YRSHRPGAGP RATDDGINPL
LQRGGRSTGR DGLPRNEGNS DWVHAIESRG PRIFNQTDSP VSFISNLLNA MSSGRGGPTL
LHHGGALHVS LGNSMGMQTF DSSMRRDIAR MRETYNSRSA REDPHSAVAF VKAYTSQRWQ
EEARILYGPA AIEKSQRVIN SILKVMVPPA IEAAKKRQEE REAEVARKLK EEQEKKEQKE
REEREKREAQ EKEDRERRER EAAEAASRAQ DQTSEGEPKN EAGTTSGEQA MEGVQAAQTS
GESATVESVP AAPAGPPAPR VMTTIRGHEY DITDLGIDTE YLEALPEELR EEVLMQQSGD
LPTDINEEFL AALPEEIREE LLAQEAQERR RREREENRRR NQSSAVAPQA EEMDTASFFA
SLDPNLRAAV LMDTDEDTLR QLPPELSAEA RAMGGDRRLH QFNEFGYRRG DRRGQPEDPN
QKKKARPCVQ MLDKAGVATL LRLMFIPQQG SAKASLSSIL CYVCENRQNR AEVISILLSI
LQDGSADVNA VERSFAQLSI RAKQPQQPAE KTPKLSRKNG ALSINADVSP LMVVQQCLNT
LTQLTEKNPA VWSFFLTEHE TGVGFKNRAN RKGKAKESKA NKYPVNALLT LLDRKLIVES
SSIMEQLTTL LKVITAPLQA LKKEKEKAAE EAKKASESSA EGQNAENQST EATSTGAAQG
QDTEMTAAPD SGATEEGASK PDRSKAEDDK TKKHRSLTPP DVPEANLRLV AKILAARECN
SKVFQETLSV ISNLSPIPGA KEIFGQELLG IAKDLASSTL RDLDSLTVQI SKASSSTDVQ
GIALAKFSPA SSDQTKLLRA LTALDYLFDP SRDSKDKPEA AAEALEPAQK EDILLTLYED
AAFAPLWEKL SECLTVIRQR GNMLNIATTL LPLIESLMVV CKNTTLKEAP LSKMLAKEFA
LSSPPPENKM ENLFFNFTEE HRKILNDLVR QNPKLMSGTF SLLVKNSKVL EFDNKRNYFN
RKLHSRGGDR QAHPPLQLSV RRDQVFLDSF KSLYFKSADE MKYGKLSIRF HGEEGVDAGG
VTREWFQSIS RQMFNPDYAL FVPVASDRTT FHPNRLSSIN PEHLMFFKFI GRIIGKALYE
GRVLDCHFSR AVYKQIMGKQ VSLKDMETLD LEYYKSLEWM IHNEITDIIT ETFSVEVEAF
GEMQTVDLIE NGRNIPVTED NKHEYVRLIT EHRLLGAVQE QLDHFLKGFH DIVPAELVSI
FSEQELELLI SGLPDINVDD WKNNTEYHNY TAASPQIQWF WRAVRTFEKE EQAKLLQFVT
GTSKVPLNGF KELEGMNGFS KFNIHRDYGS KDRLPSSHTC FNQLDLPEYE TYEDLRKALY
TAMTAGGEYF GFA
//